ENSMUSG00000041598


Mus musculus

Features
Gene ID: ENSMUSG00000041598
  
Biological name :Cdc42ep4
  
Synonyms : Cdc42 effector protein 4 / Cdc42ep4 / Q9JM96
  
Possible biological names infered from orthology : Q9H3Q1
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E2
Gene start: 113726850
Gene end: 113751881
  
Corresponding Affymetrix probe sets: 10392735 (MoGene1.0st)   1416511_a_at (Mouse Genome 430 2.0 Array)   1436801_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120316
Ensembl peptide - ENSMUSP00000060227
Ensembl peptide - ENSMUSP00000102227
Ensembl peptide - ENSMUSP00000114599
NCBI entrez gene - 56699     See in Manteia.
MGI - MGI:1929760
RefSeq - XM_017314686
RefSeq - NM_001163346
RefSeq - NM_020006
RefSeq - XM_006533817
RefSeq - XM_006533818
RefSeq - XM_006533819
RefSeq Peptide - NP_001156818
RefSeq Peptide - NP_064390
swissprot - A2A6Q3
swissprot - Q9JM96
swissprot - A2A6Q2
Ensembl - ENSMUSG00000041598
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdc42ep4aENSDARG00000101457Danio rerio
 cdc42ep4bENSDARG00000045036Danio rerio
 CDC42EP4ENSGALG00000023364Gallus gallus
 Q9H3Q1ENSG00000179604Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cdc42ep1 / CDC42 effector protein 1 / Q00587*ENSMUSG0000004952126
Q9Z0X0 / 1700027J19Rik / CDC42 effector protein (Rho GTPase binding) 5 / Q6NZY7* / CDC42EP5* / CDC42 effector protein 5*ENSMUSG0000006383816


Protein motifs (from Interpro)
Interpro ID Name
 IPR000095  CRIB domain
 IPR029273  Cdc42 effector


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007266 Rho protein signal transduction IDA
 biological_processGO:0008360 regulation of cell shape ISO
 biological_processGO:0030838 positive regulation of actin filament polymerization IBA
 biological_processGO:0031274 positive regulation of pseudopodium assembly ISO
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0071346 cellular response to interferon-gamma IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0005913 cell-cell adherens junction ISO
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0015629 actin cytoskeleton ISO
 cellular_componentGO:0015630 microtubule cytoskeleton ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0045335 phagocytic vesicle IDA
 molecular_functionGO:0005096 GTPase activator activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017049 GTP-Rho binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002804 abnormal motor learning "defects in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Ppp1r13ltm1.1Xlu/Ppp1r13ltm1.1Xlu
Genetic Background: involves: 129 * C57BL/6J

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Ppp1r13ltm1.1Xlu/Ppp1r13ltm1.1Xlu
Genetic Background: involves: 129 * C57BL/6J

 MP:0003312 abnormal locomotor coordination "reduced ability of an animal to maintain skillful and effective interaction of movements while engaging in locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ppp1r13ltm1.1Xlu/Ppp1r13ltm1.1Xlu
Genetic Background: involves: 129 * C57BL/6J

 MP:0003635 abnormal synaptic transmission "defect in the communication from a neuron to a target across a synapse " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ppp1r13ltm1.1Xlu/Ppp1r13ltm1.1Xlu
Genetic Background: involves: 129 * C57BL/6J

 MP:0011002 enhanced AMPA-mediated synaptic currents "increase in the measured amplitude, current density or duration of response to stimulation of AMPA receptors" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ppp1r13ltm1.1Xlu/Ppp1r13ltm1.1Xlu
Genetic Background: involves: 129 * C57BL/6J

 MP:0011273 prolonged excitatory postsynaptic current decay time 
Show

Allelic Composition: Ppp1r13ltm1.1Xlu/Ppp1r13ltm1.1Xlu
Genetic Background: involves: 129 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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