Manteia - Molecule gene

ENSMUSG00000041607

Mus musculus

Features

Gene ID:	ENSMUSG00000041607

Biological name :	Mbp

Synonyms :	Mbp / Myelin basic protein / P04370

Possible biological names infered from orthology :	P02686

Species:	Mus musculus

Chr. number:	18
Strand:	1
Band:	E3
Gene start:	82475146
Gene end:	82585637

Corresponding Affymetrix probe sets:	10457022 (MoGene1.0st) 1419646_a_at (Mouse Genome 430 2.0 Array) 1425263_a_at (Mouse Genome 430 2.0 Array) 1425264_s_at (Mouse Genome 430 2.0 Array) 1433532_a_at (Mouse Genome 430 2.0 Array) 1436201_x_at (Mouse Genome 430 2.0 Array) 1451961_a_at (Mouse Genome 430 2.0 Array) 1454651_x_at (Mouse Genome 430 2.0 Array) 1456228_x_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000138313 Ensembl peptide - ENSMUSP00000116019 Ensembl peptide - ENSMUSP00000121855 Ensembl peptide - ENSMUSP00000046185 Ensembl peptide - ENSMUSP00000053495 Ensembl peptide - ENSMUSP00000074836 Ensembl peptide - ENSMUSP00000079488 Ensembl peptide - ENSMUSP00000089393 Ensembl peptide - ENSMUSP00000099876 Ensembl peptide - ENSMUSP00000110322 Ensembl peptide - ENSMUSP00000110324 Ensembl peptide - ENSMUSP00000114230 Ensembl peptide - ENSMUSP00000114630 Ensembl peptide - ENSMUSP00000115082 Ensembl peptide - ENSMUSP00000115409 NCBI entrez gene - 17196 See in Manteia. MGI - MGI:96925 RefSeq - XM_006526458 RefSeq - NM_001025245 RefSeq - NM_001025251 RefSeq - NM_001025254 RefSeq - NM_001025255 RefSeq - NM_001025256 RefSeq - NM_001025258 RefSeq - NM_001025259 RefSeq - NM_010777 RefSeq - XM_006526452 RefSeq - XM_006526453 RefSeq - XM_006526454 RefSeq - XM_006526455 RefSeq - XM_006526456 RefSeq - XM_006526457 RefSeq Peptide - NP_001020427 RefSeq Peptide - NP_001020429 RefSeq Peptide - NP_001020430 RefSeq Peptide - NP_034907 RefSeq Peptide - NP_001020422 RefSeq Peptide - NP_001020425 RefSeq Peptide - NP_001020426 RefSeq Peptide - NP_001020416 swissprot - Q542T4 swissprot - Q5D096 swissprot - D3Z6U4 swissprot - F6RWW8 swissprot - F6TYB7 swissprot - F6VME3 swissprot - F6ZIA4 swissprot - F7A0B0 swissprot - F6RT34 swissprot - P04370 Ensembl - ENSMUSG00000041607

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
mbpb	ENSDARG00000089413	Danio rerio
MBP	ENSGALG00000013640	Gallus gallus
MBP	ENSG00000197971	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR000548	Myelin basic protein

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000165	MAPK cascade	ISO
biological_process	GO:0007417	central nervous system development	IBA
biological_process	GO:0007605	sensory perception of sound	IMP
biological_process	GO:0009636	response to toxic substance	IDA
biological_process	GO:0034115	negative regulation of heterotypic cell-cell adhesion	ISO
biological_process	GO:0035633	maintenance of permeability of blood-brain barrier	ISO
biological_process	GO:0042552	myelination	IDA
biological_process	GO:0061024	membrane organization	IDA
biological_process	GO:1904209	positive regulation of chemokine (C-C motif) ligand 2 secretion	ISO
biological_process	GO:1904685	positive regulation of metalloendopeptidase activity	ISO
biological_process	GO:2000778	positive regulation of interleukin-6 secretion	ISO
cellular_component	GO:0005622	intracellular	ISO
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0032991	protein-containing complex	IDA
cellular_component	GO:0033269	internode region of axon	IDA
cellular_component	GO:0042995	cell projection	IDA
cellular_component	GO:0043025	neuronal cell body	IDA
cellular_component	GO:0043209	myelin sheath	ISO
cellular_component	GO:0043218	compact myelin	IDA
cellular_component	GO:0071944	cell periphery	IDA
molecular_function	GO:0002020	protease binding	IPI
molecular_function	GO:0005516	calmodulin binding	IPI
molecular_function	GO:0019911	structural constituent of myelin sheath	IBA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000745	tremors	"repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Plp1^tm1Kan/Y Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Mbp^shi/Mbp^shi Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SWV Allelic Composition: Mbp^shi-J/Mbp^shi-J Genetic Background: BALB/cJ-Mbp^shi-J/GrsrJ Allelic Composition: Mbp^shi/Mbp^shi Genetic Background: C3Fe.SWV-Mbp^shi/J Allelic Composition: Mbp^jve/Mbp^jve Genetic Background: involves: C57BL/6J Allelic Composition: Mbp^shi-mld+/Mbp^shi-mld+ Genetic Background: involves: C3H/HeJ * C57BL/6J * MDB/Dt Allelic Composition: Mbp^shi/Mbp^shi Genetic Background: involves: C3H * ICR * SWV Allelic Composition: Mbp^shi-mld/Mbp^shi-mld Genetic Background: MDB/Dt Allelic Composition: Mbp^shi/Mbp^shi,Pmp2^{tm1.1(KOMP)Vlcg}/Pmp2^{tm1.1(KOMP)Vlcg} Genetic Background: involves: C3HeB/FeJ * C57BL/6 * C57BL/6NTac
MP:0000754	partial paralysis	"partial loss of power of voluntary movement in a muscle through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Mbp^shi/Mbp^shi,Tg(Thy1-YFP)HJrs/0 Genetic Background: involves: C3HeB/Fe * C57BL/6 * CBA * SWV
MP:0000755	hindlimb paralysis	"loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Mbp^shi/Mbp^shi Genetic Background: involves: C3H * ICR * SWV
MP:0000780	abnormal corpus callosum morphology	"malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Mbp^jve/Mbp^jve Genetic Background: involves: C57BL/6J
MP:0000920	abnormal myelination	"atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pten^tm2Mak/Pten^tm2Mak,Smad4^tm2.1Cxd/Smad4^tm2.1Cxd,Tg(KRT5-cre)1Xya/0 Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac Allelic Composition: Mbp^shi/Mbp^shi,Plp1^tm1Kan/Y Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SWV Allelic Composition: Mbp^shi/Mbp^shi Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SWV Allelic Composition: Mbp^shi-J/Mbp^shi-J Genetic Background: BALB/cJ-Mbp^shi-J/GrsrJ Allelic Composition: Mbp^shi/Mbp^shi Genetic Background: involves: SWV Allelic Composition: Mbp^shi/Mbp^shi,Tg(Thy1-YFP)HJrs/0 Genetic Background: involves: C3HeB/Fe * C57BL/6 * CBA * SWV
MP:0000921	demyelination	"loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Mbp^shi/Mbp^shi,Plp1^tm1Kan/Y Genetic Background: involves: 129S1/Sv * 129X1/SvJ * SWV Allelic Composition: Mbp^shi-mld+/Mbp^shi-mld+ Genetic Background: involves: C3H/HeJ * C57BL/6J * MDB/Dt Allelic Composition: Mbp^shi/Mbp^shi,Tg(Thy1-YFP)HJrs/0 Genetic Background: involves: C3HeB/Fe * C57BL/6 * CBA * SWV
MP:0000947	convulsive seizures	"seizures characterized by uncontrolled motor activity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Oat^rhg/Oat^rhg Genetic Background: B6Ei;AKR-Oat^rhg/J
MP:0000951	sporadic seizures	"occasional seizures occuring at irregular intervals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Mbp^shi-mld/Mbp^shi-mld Genetic Background: MDB/Dt
MP:0000953	abnormal oligodendrocyte morphology	"anomalous structure, number or composition of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Pten^tm2Mak/Pten^tm2Mak,Smad4^tm2.1Cxd/Smad4^tm2.1Cxd,Tg(KRT5-cre)1Xya/0 Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Mbp^jve/Mbp^jve Genetic Background: involves: C57BL/6J
MP:0001386	abnormal maternal nurturing	"failure of mothers to tend offspring" [J:39801]	Show Allelic Composition: Mbp^shi/Mbp^shi Genetic Background: SWV-Mbp^shi
MP:0001393	ataxia	"inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]	Show Allelic Composition: Mbp^shi/Mbp^shi,Plp1^tm1Kan/Y Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SWV Allelic Composition: Mbp^shi/Mbp^shi Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SWV Allelic Composition: Mbp^shi-J/Mbp^shi-J Genetic Background: BALB/cJ-Mbp^shi-J/GrsrJ
MP:0001402	hypoactivity	"reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]	Show Allelic Composition: Mbp^jve/Mbp^jve Genetic Background: involves: C57BL/6J
MP:0001405	impaired coordination	"reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Mbp^shi/Mbp^shi Genetic Background: involves: C3H * ICR * SWV Allelic Composition: Mbp^shi/Mbp^shi,Tg(Thy1-YFP)HJrs/0 Genetic Background: involves: C3HeB/Fe * C57BL/6 * CBA * SWV
MP:0001406	abnormal gait	"unusual or distinctive way of walking" [J:65038]	Show Allelic Composition: Mbp^jve/Mbp^jve Genetic Background: involves: C57BL/6J
MP:0001463	abnormal spatial learning	"defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]	Show Allelic Composition: Mbp^shi/Mbp^shi Genetic Background: SWV-Mbp^shi
MP:0001489	decreased startle reflex	"greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]	Show Allelic Composition: Mbp^jve/Mbp^jve Genetic Background: involves: C57BL/6J
MP:0001496	audiogenic seizures	"a reflex seizure triggered by loud noises" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Mbp^shi/Mbp^shi Genetic Background: involves: C3H * ICR * SWV
MP:0001513	limb grasping	"mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Qk^qk-v/Qk^qk-v Genetic Background: B6C3Fe a/a-Qk^qk-v/J Allelic Composition: Mbp^shi/Mbp^shi,Pmp2^{tm1.1(KOMP)Vlcg}/Pmp2^{tm1.1(KOMP)Vlcg} Genetic Background: involves: C3HeB/FeJ * C57BL/6 * C57BL/6NTac
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Mbp^shi/Mbp^shi,Plp1^tm1Kan/Y Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SWV Allelic Composition: Mbp^jve/Mbp^jve Genetic Background: involves: C57BL/6J Allelic Composition: Mbp^shi/Mbp^shi Genetic Background: SWV-Mbp^shi Allelic Composition: Mbp^shi/Mbp^shi Genetic Background: involves: C3H * ICR * SWV Allelic Composition: Mbp^shi-mld/Mbp^shi-mld Genetic Background: MDB/Dt
MP:0002206	abnormal CNS synaptic transmission	"defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Pten^tm2Mak/Pten^tm2Mak,Smad4^tm2.1Cxd/Smad4^tm2.1Cxd,Tg(KRT5-cre)1Xya/0 Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
MP:0002410	decreased susceptibility to viral infection	"reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Mbp^shi/Mbp^shi Genetic Background: C3Fe.SWV-Mbp^shi/J
MP:0002826	tonic seizures	"increased number or decreased threshold for the induction of a seizure characterized by muscle rigidity" [hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Mbp^jve/Mbp^jve Genetic Background: involves: C57BL/6J Allelic Composition: Mbp^shi/Mbp^shi Genetic Background: involves: C3H * ICR * SWV
MP:0002882	abnormal neuron	"anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Mbp^shi/Mbp^shi Genetic Background: involves: SWV
MP:0002906	susceptibility to pharmacologically induced seizures	"inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]	Show Allelic Composition: Mbp^shi/Mbp^shi,Tg(Thy1-YFP)HJrs/0 Genetic Background: involves: C3HeB/Fe * C57BL/6 * CBA * SWV
MP:0003171	phenotypic reversion	"reverse mutation to wild-type phenotype from a previously characterized mutant phenotype" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Mbp^shi-mld+/Mbp^shi-mld+ Genetic Background: involves: C3H/HeJ * C57BL/6J * MDB/Dt
MP:0003175	reversion by mitotic recombination	"cross-over event between sequences containing mutant and wild-type alleles during DNA replication in a heterozygote resulting in cells with two wild-type alleles" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Mbp^shi-mld+/Mbp^shi-mld+ Genetic Background: involves: C3H/HeJ * C57BL/6J * MDB/Dt
MP:0003216	absence seizures	"impairment of consciousness without convulsions associated with widespread bilaterally synchronous spike-and-wave discharges (SWDs) in the electroencephalogram (EEG)" [RGD:Rat Genome Database submission]	Show Allelic Composition: Mbp^jve/Mbp^jve Genetic Background: involves: C57BL/6J
MP:0003871	abnormal myelin sheath morphology	"malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Mbp^shi/Mbp^shi,Plp1^tm1Kan/Y Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SWV Allelic Composition: Mbp^shi/Mbp^shi Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SWV Allelic Composition: Mbp^shi-J/Mbp^shi-J Genetic Background: BALB/cJ-Mbp^shi-J/GrsrJ Allelic Composition: Mbp^shi/Mbp^shi Genetic Background: C3Fe.SWV-Mbp^shi/J Allelic Composition: Mbp^shi/Mbp^shi,Pmp2^{tm1.1(KOMP)Vlcg}/Pmp2^{tm1.1(KOMP)Vlcg} Genetic Background: involves: C3HeB/FeJ * C57BL/6 * C57BL/6NTac
MP:0003983	decreased cholesterol level	"less than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Mbp^shi/Mbp^shi Genetic Background: SWV-Mbp^shi
MP:0004768	abnormal axonal transport	"any functional anomaly of the directed movement of organelles or vesicles along microtubules in nerve cell axons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mbp^shi/Mbp^shi Genetic Background: involves: SWV
MP:0004799	increased susceptibility to experimental autoimmune encephalomyelitis	"greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mbp^shi/Mbp^shi Genetic Background: involves: SWV
MP:0004813	absent linear vestibular evoked potential	"absence of the biphasic response elicited by linear acceleration transients (usually jerk pulses to an animal s head)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Zap70^m1Saka/Zap70^tm1Dlo,Tg(Lck-ZAP70)824Saka/0 Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0004814	reduced linear vestibular evoked potential	"reduction of the biphasic response elicited by linear acceleration transients (usually jerk pulses to an animal s head)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Zap70^m1Saka/Zap70^tm1Dlo,Tg(Lck-ZAP70)824Saka/0 Genetic Background: involves: 129P2/OlaHsd * BALB/c Allelic Composition: Mbp^shi/Mbp^shi Genetic Background: C3Fe.SWV-Mbp^shi/J
MP:0004924	abnormal behavior	"anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mbp^shi-mld/Mbp^shi-mld Genetic Background: MDB/Dt
MP:0005348	increased T cell proliferation	"increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Mbp^shi/Mbp^shi Genetic Background: involves: SWV
MP:0005402	abnormal action potential	"change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Mbp^jve/Mbp^jve Genetic Background: involves: C57BL/6J
MP:0008026	abnormal brain white matter morphology	"any structural anomaly of the regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mbp^jve/Mbp^jve Genetic Background: involves: C57BL/6J
MP:0008235	increased susceptibility to neuronal excitotoxicity	"greater than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mbp^shi/Mbp^shi,Tg(Thy1-YFP)HJrs/0 Genetic Background: involves: C3HeB/Fe * C57BL/6 * CBA * SWV
MP:0008566	increased interferon-gamma secretion	"increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]	Show Allelic Composition: Mbp^shi/Mbp^shi Genetic Background: involves: SWV
MP:0008687	increased interleukin-2 secretion	"increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]	Show Allelic Composition: Mbp^shi/Mbp^shi Genetic Background: involves: SWV
MP:0008699	increased interleukin-4 secretion	"increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]	Show Allelic Composition: Mbp^shi/Mbp^shi Genetic Background: involves: SWV
MP:0008814	reduced nerve conduction velocity	"decrease in the rate at which an eletrical impulse travels through a nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mbp^shi/Mbp^shi Genetic Background: C3Fe.SWV-Mbp^shi/J Allelic Composition: Mbp^shi/Mbp^shi,Pmp2^{tm1.1(KOMP)Vlcg}/Pmp2^{tm1.1(KOMP)Vlcg} Genetic Background: involves: C3HeB/FeJ * C57BL/6 * C57BL/6NTac
MP:0009358	environmentally induced seizures	"relatively mild but sudden stimulation due to changes in ambient habitat including lighting, sounds, touching, and/ or moving cage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mbp^jve/Mbp^jve Genetic Background: involves: C57BL/6J Allelic Composition: Mbp^shi/Mbp^shi Genetic Background: involves: C3H * ICR * SWV
MP:0009978	abnormal cerebellum white matter morphology		Show Allelic Composition: Mbp^jve/Mbp^jve Genetic Background: involves: C57BL/6J
MP:0010047	axonal spheroids	"focal 10-50 micron diameter swellings of axons, which are sometimes, but not always, terminal endbulbs, and are filled with disorganized neurofilaments, tubules, organelles or multi-lamellar inclusions" [PMID:15644421]	Show Allelic Composition: Mbp^shi/Mbp^shi,Plp1^tm1Kan/Y Genetic Background: involves: 129S1/Sv * 129X1/SvJ * SWV
MP:0010161	decreased brain cholesterol level	"less than normal amount in the brain of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mbp^shi/Mbp^shi Genetic Background: SWV-Mbp^shi
MP:0011966	abnormal auditory brainstem response waveform shape	"any anomaly in the characteristic pattern of electrical activity recording of a series of vertex positive waves generated by neurons in the ascending auditory system, that can be recorded from scalp electrograms by using computer-averaged responses to short tone bursts" [MGI:csmith]	Show Allelic Composition: Mbp^shi-J/Mbp^shi-J Genetic Background: BALB/cJ-Mbp^shi-J/GrsrJ
MP:0011967	increased or absent threshold for auditory brainstem response	"increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]	Show Allelic Composition: Mbp^shi-J/Mbp^shi-J Genetic Background: BALB/cJ-Mbp^shi-J/GrsrJ Allelic Composition: Mbp^jve/Mbp^jve Genetic Background: involves: C57BL/6J

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr