ENSMUSG00000041616


Mus musculus

Features
Gene ID: ENSMUSG00000041616
  
Biological name :Nppa
  
Synonyms : natriuretic peptide type A / Nppa / P05125
  
Possible biological names infered from orthology : natriuretic peptide A / P01160
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: E2
Gene start: 148000722
Gene end: 148002079
  
Corresponding Affymetrix probe sets: 10510265 (MoGene1.0st)   1456062_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099520
NCBI entrez gene - 230899     See in Manteia.
MGI - MGI:97367
RefSeq - NM_008725
RefSeq Peptide - NP_032751
swissprot - P05125
Ensembl - ENSMUSG00000041616
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NPPAENSG00000175206Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000663  Natriuretic peptide
 IPR002407  Natriuretic peptide, atrial type
 IPR030480  Natriuretic peptide, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0003085 negative regulation of systemic arterial blood pressure IEA
 biological_processGO:0006182 cGMP biosynthetic process IEA
 biological_processGO:0006457 protein folding IEA
 biological_processGO:0007168 receptor guanylyl cyclase signaling pathway IEA
 biological_processGO:0007218 neuropeptide signaling pathway IEA
 biological_processGO:0007565 female pregnancy IMP
 biological_processGO:0008217 regulation of blood pressure IMP
 biological_processGO:0010460 positive regulation of heart rate IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0014898 cardiac muscle hypertrophy in response to stress IMP
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0050880 regulation of blood vessel size IEA
 biological_processGO:0060372 regulation of atrial cardiac muscle cell membrane repolarization IEA
 biological_processGO:0060452 positive regulation of cardiac muscle contraction IEA
 biological_processGO:0061049 cell growth involved in cardiac muscle cell development IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:1901841 regulation of high voltage-gated calcium channel activity IEA
 biological_processGO:1902261 positive regulation of delayed rectifier potassium channel activity IEA
 biological_processGO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel IEA
 biological_processGO:1903595 positive regulation of histamine secretion by mast cell IEA
 biological_processGO:1903766 positive regulation of potassium ion export across plasma membrane IEA
 biological_processGO:1903815 negative regulation of collecting lymphatic vessel constriction IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0042629 mast cell granule IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0005184 neuropeptide hormone activity IEA
 molecular_functionGO:0051427 hormone receptor binding IEA
 molecular_functionGO:0051428 peptide hormone receptor binding IEA
 molecular_functionGO:0071855 neuropeptide receptor binding IEA


Pathways (from Reactome)
Pathway description
Physiological factors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Bbs4tm1Vcs/Bbs4tm1Vcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000230 abnormal blood pressure "altered tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bbs4tm1Vcs/Bbs4tm1Vcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000231 hypertension "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Bbs4tm1Vcs/Bbs4tm1Vcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Bbs4tm1Vcs/Bbs4tm1Vcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000276 right ventricle hypertrophy "increased size of the right ventricle" [J:33629]
Show

Allelic Composition: Bbs4tm1Vcs/Bbs4tm1Vcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Nppatm1Unc/Nppa+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bbs4tm1Vcs/Bbs4tm1Vcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002625 left ventricle hypertrophy "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Bbs4tm1Vcs/Bbs4tm1Vcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bbs4tm1Vcs/Bbs4tm1Vcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Bbs4tm1Vcs/Bbs4tm1Vcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003393 decreased cardiac output "reduction in the blood volume pumped by each ventricle per minute" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Bbs4tm1Vcs/Bbs4tm1Vcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003548 pulmonary hypertension "sustained high pulmonary pressure at a level that is likely to result in disease and/or other pathological states" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:54986]
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Allelic Composition: Bbs4tm1Vcs/Bbs4tm1Vcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004217 salt-sensitive hypertension "sustained high blood pressure that is maintained with a normal or increase in the amount of salt consumed in the diet; blood pressure may return to normotensive with a low salt diet" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bbs4tm1Vcs/Bbs4tm1Vcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Nppatm1Unc/Nppa+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005532 abnormal vascular resistance "deviation from the normal force opposing the flow of blood through a vascular bed; it is equal to the difference in blood pressure across the vascular bed divided by the cardiac output" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bbs4tm1Vcs/Bbs4tm1Vcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005581 abnormal renin activity "alterated ability of this enzyme to cleave angiotensinogen and create angiotensin I" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bbs4tm1Vcs/Bbs4tm1Vcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005592 abnormal vascular smooth muscle morphology "structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bbs4tm1Vcs/Bbs4tm1Vcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005662 increased circulating adrenaline level "greater than the normal concentration in the blood of this catacholamine hormone that stimulates the adrenergic receptors and that causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bbs4tm1Vcs/Bbs4tm1Vcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006143 increased diastolic blood pressure "abnormal increase in the pressure in the arteries between heart beats when the heart is relaxed" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Bbs4tm1Vcs/Bbs4tm1Vcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008776 increased right ventricular peak pressure "increase in the difference between right ventricular systolic and diastolic pressures" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bbs4tm1Vcs/Bbs4tm1Vcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010109 abnormal renal sodium reabsorption "any anomaly in the process by which sodium ions are transported out of the renal tubules back into the bloodstream" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bbs4tm1Vcs/Bbs4tm1Vcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010755 abnormal heart right ventricle pressure "any anomaly in the pressure within the right cardiac ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nppatm1Unc/Nppa+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005220 Corin / Q9Z319 / Atrial natriuretic peptide-converting enzyme Atrial natriuretic peptide-converting enzyme, N-terminal propeptide Atrial natriuretic peptide-converting enzyme, activated prot...  / reaction
 ENSMUSG00000027931 Npr1 / P18293 / natriuretic peptide receptor 1 / P16066*  / reaction / complex






 

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