ENSMUSG00000027931


Mus musculus

Features
Gene ID: ENSMUSG00000027931
  
Biological name :Npr1
  
Synonyms : natriuretic peptide receptor 1 / Npr1 / P18293
  
Possible biological names infered from orthology : P16066
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F1
Gene start: 90450591
Gene end: 90465866
  
Corresponding Affymetrix probe sets: 10499811 (MoGene1.0st)   1449160_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029540
Ensembl peptide - ENSMUSP00000118023
NCBI entrez gene - 18160     See in Manteia.
MGI - MGI:97371
RefSeq - NM_008727
RefSeq Peptide - NP_032753
swissprot - F6W125
swissprot - P18293
swissprot - Q2TAY4
Ensembl - ENSMUSG00000027931
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 npr1aENSDARG00000031751Danio rerio
 npr1bENSDARG00000018750Danio rerio
 NPR1ENSG00000169418Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Npr2 / Q6VVW5 / natriuretic peptide receptor 2 / P20594*ENSMUSG0000002846960
Gucy2f / Q5SDA5 / Retinal guanylyl cyclase 2 / P51841* / guanylate cyclase 2F, retinal*ENSMUSG0000004228233
Gucy2g / Q6TL19 / Guanylate cyclase 2G ENSMUSG0000005552332
Gucy2e / P52785 / Guanylyl cyclase GC-E / GUCY2D* / Q02846* / guanylate cyclase 2D, retinal*ENSMUSG0000002089031
Gucy2dENSMUSG0000007400330
Gucy2c / Q3UWA6 / Heat-stable enterotoxin receptor / P25092* / guanylate cyclase 2C*ENSMUSG0000004263829
Gucy1b2ENSMUSG0000002193317
Gucy1a2 / guanylate cyclase 1 soluble subunit alpha 2 / P33402*ENSMUSG0000004162415
O54865 / Gucy1b1 / guanylate cyclase 1, soluble, beta 1 / Q02153* / guanylate cyclase 1 soluble subunit beta 1*ENSMUSG0000002800514
Q9ERL9 / Gucy1a1 / guanylate cyclase 1, soluble, alpha 1 / Q02108* / guanylate cyclase 1 soluble subunit alpha 1*ENSMUSG0000003391014


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001054  Adenylyl cyclase class-3/4/guanylyl cyclase
 IPR001170  Adenylyl cyclase class-4/guanylyl cyclase
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001828  Receptor, ligand binding region
 IPR011009  Protein kinase-like domain superfamily
 IPR018297  Adenylyl cyclase class-4/guanylyl cyclase, conserved site
 IPR028082  Periplasmic binding protein-like I
 IPR029787  Nucleotide cyclase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006182 cGMP biosynthetic process IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007168 receptor guanylyl cyclase signaling pathway IEA
 biological_processGO:0009190 cyclic nucleotide biosynthetic process IEA
 biological_processGO:0030828 obsolete positive regulation of cGMP biosynthetic process IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042417 dopamine metabolic process IEA
 biological_processGO:0048662 negative regulation of smooth muscle cell proliferation IEA
 biological_processGO:0050880 regulation of blood vessel size IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0008074 guanylate cyclase complex, soluble IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004383 guanylate cyclase activity IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0016849 phosphorus-oxygen lyase activity IEA
 molecular_functionGO:0016941 natriuretic peptide receptor activity IEA
 molecular_functionGO:0017046 peptide hormone binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0042562 hormone binding IEA


Pathways (from Reactome)
Pathway description
Physiological factors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000230 abnormal blood pressure "altered tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Acox1tm1Jkr/Acox1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Npr1tm1Gar/Npr1tm1Gar
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000231 hypertension "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Unc5crcm/Unc5crcm
Genetic Background: C57BL/6J-Unc5crcm

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Unc5crcm/Unc5crcm
Genetic Background: C57BL/6J-Unc5crcm

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Slc12a5tm1Dlp/Slc12a5+
Genetic Background: involves: C57BL/6J

 MP:0001272 increased metastatic potential 
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Allelic Composition: Npr1tm1.1Kkan/Npr1tm1.1Kkan,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * SJL

 MP:0001596 hypotension "sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Slc12a5tm1Dlp/Slc12a5+
Genetic Background: involves: C57BL/6J

 MP:0001613 abnormal vasodilation "anomalous widening of the lumen of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Acox1tm1Jkr/Acox1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Npr1tm1Gar/Npr1tm1Gar
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nr4a2tm1Omc/Nr4a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Npr1tm1Mae/Npr1tm1Mae
Genetic Background: B6.129P2-Npr1tm1Mae

Allelic Composition: Npr1tm1Kuhn/Npr1tm1Kuhn,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Npr1tm1.1Rsha/Npr1tm1.1Rsha
Genetic Background: involves: C57BL/6

Allelic Composition: Npr1tm1.1Rsha/Npr1+
Genetic Background: involves: C57BL/6

Allelic Composition: Npr1tm1.1Kkan/Npr1tm1.1Kkan,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * SJL

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nr4a2tm1Omc/Nr4a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Npr1tm1Gar/Npr1tm1Gar
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002295 abnormal pulmonary circulation "anomalous circulation of blood through the lungs" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nr4a2tm1Omc/Nr4a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002666 increased circulating aldosterone level "increased blood concentration of this hormone, secreted by the adrenal cortex, in the bloodstream; regulates sodium conservation and potassium secretion in the distal renal tubule" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tgif1tm1.1Caw/Tgif1tm1.1Caw
Genetic Background: B6.129S-Tgif1tm1.1Caw

Allelic Composition: Npr1tm1.1Rsha/Npr1+
Genetic Background: involves: C57BL/6

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Nr4a2tm1Omc/Nr4a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002754 dilated right ventricle "an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Nr4a2tm1Omc/Nr4a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002780 decreased circulating testosterone level "less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nr4a2tm1Omc/Nr4a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002781 increased circulating testosterone level "greater than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Npr1tm1Mae/Npr1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Npr1tm1.1Rsha/Npr1tm1.1Rsha
Genetic Background: involves: C57BL/6

Allelic Composition: Npr1tm1.1Rsha/Npr1+
Genetic Background: involves: C57BL/6

 MP:0002842 increased blood pressure "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Npr1tm1Gar/Npr1tm1Gar
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Npr1tm1Gar/Npr1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Npr1tm1Mae/Npr1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Npr1tm1.1Kkan/Npr1tm1.1Kkan,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * SJL

 MP:0002843 decreased blood pressure "decreased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Npr1tm1Mae/Npr1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Npr1tm1(Npr1)Unc/Npr1tm1(Npr1)Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003038 decreased infarction size "decreased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Zfp36l1tm1Seb/Zfp36l1tm1Seb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0003353 decreased circulating renin level "reduced blood concentration of this enzyme which is secreted by the kidney; it cleaves a bond in angiotensionogen to generate angiotensin I " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Nr4a2tm1Omc/Nr4a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004044 aortic dissection "a pathologic process, characterized by splitting of the media layer of the aorta, which leads to formation of a dissecting aneurysm" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Nr4a2tm1Omc/Nr4a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004084 abnormal cardiac muscle relaxation "altered ability of the cardiac/heart muscle to lengthen following contractions, often measured by dP/dt min" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Npr1tm1Kuhn/Npr1tm1Kuhn,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0004216 salt-resistant hypertension "sustained high blood pressure that is maintained regardless of the amount of salt consumed in the diet" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr4a2tm1Omc/Nr4a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Npr1tm1Gar/Npr1tm1Gar
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Npr1tm1Gar/Npr1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004875 increased mean arterial blood pressure "increase in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Npr1tm1.1Rsha/Npr1tm1.1Rsha
Genetic Background: involves: C57BL/6

Allelic Composition: Npr1tm1.1Rsha/Npr1+
Genetic Background: involves: C57BL/6

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Nr4a2tm1Omc/Nr4a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005522 increased circulating atrial natriuretic factor "greater than the normal concentration of this peptide hormone in the blood; it regulates the water-electrolyte balance and acts as a vasodilator" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Npr1tm1Gar/Npr1tm1Gar
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Npr1tm1Mae/Npr1tm1Mae
Genetic Background: B6.129P2-Npr1tm1Mae

Allelic Composition: Npr1tm1Kuhn/Npr1tm1Kuhn,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Nr4a2tm1Omc/Nr4a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Npr1tm1Kuhn/Npr1tm1Kuhn,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0005647 abnormal sex gland physiology "anomalous function of any of the organized aggregations of cells that function as secretory or excretory organs and are associated with reproduction" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nr4a2tm1Omc/Nr4a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Npr1tm1(Npr1)Unc/Npr1tm1(Npr1)Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006085 myocardial necrosis "pathological cell death of the cardiac muscle cells, usually due to irreversible damage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92722]
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Allelic Composition: Nr4a2tm1Omc/Nr4a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nr4a2tm1Omc/Nr4a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Npr1tm1Mae/Npr1tm1Mae
Genetic Background: B6.129P2-Npr1tm1Mae

Allelic Composition: Npr1tm1Mae/Npr1+
Genetic Background: B6.129P2-Npr1tm1Mae

Allelic Composition: Npr1tm1Kuhn/Npr1tm1Kuhn,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0006143 increased diastolic blood pressure "abnormal increase in the pressure in the arteries between heart beats when the heart is relaxed" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Npr1tm1Gar/Npr1tm1Gar
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Npr1tm1Gar/Npr1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Npr1tm1Gar/Npr1tm1Gar
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Npr1tm1Gar/Npr1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Npr1tm1.1Rsha/Npr1tm1.1Rsha
Genetic Background: involves: C57BL/6

Allelic Composition: Npr1tm1.1Rsha/Npr1+
Genetic Background: involves: C57BL/6

 MP:0006264 decreased systolic blood pressure "abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]
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Allelic Composition: Npr1tm1Kuhn/Npr1tm1Kuhn,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0008720 impaired neutrophil migration "defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Zfp36l1tm1Seb/Zfp36l1tm1Seb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Npr1tm1.1Kkan/Npr1tm1.1Kkan,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000041616 Nppa / P05125 / natriuretic peptide type A / P01160* / natriuretic peptide A*  / reaction / complex
 ENSMUSG00000027931 Npr1 / P18293 / natriuretic peptide receptor 1 / P16066*  / complex






 

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