Manteia - Molecule gene

ENSMUSG00000028469

Mus musculus

Features

Gene ID:	ENSMUSG00000028469

Biological name :	Npr2

Synonyms :	natriuretic peptide receptor 2 / Npr2 / Q6VVW5

Possible biological names infered from orthology :	P20594

Species:	Mus musculus

Chr. number:	4
Strand:	1
Band:	A5
Gene start:	43631935
Gene end:	43651244

Corresponding Affymetrix probe sets:	10504375 (MoGene1.0st) 1427191_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000030191 Ensembl peptide - ENSMUSP00000103506 Ensembl peptide - ENSMUSP00000114385 Ensembl peptide - ENSMUSP00000117761 NCBI entrez gene - 230103 See in Manteia. MGI - MGI:97372 RefSeq - XM_006537833 RefSeq - NM_173788 RefSeq Peptide - NP_776149 swissprot - F6YN80 swissprot - B1AWI7 swissprot - Q6VVW5 swissprot - F6YT88 Ensembl - ENSMUSG00000028469

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
npr2	ENSDARG00000104393	Danio rerio
NPR2	ENSGALG00000027630	Gallus gallus
NPR2	ENSG00000159899	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Npr1 / P18293 / natriuretic peptide receptor 1 / P16066*	ENSMUSG00000027931	61
Gucy2f / Q5SDA5 / Retinal guanylyl cyclase 2 / P51841* / guanylate cyclase 2F, retinal*	ENSMUSG00000042282	34
Gucy2e / P52785 / Guanylyl cyclase GC-E / GUCY2D* / Q02846* / guanylate cyclase 2D, retinal*	ENSMUSG00000020890	33
Gucy2g / Q6TL19 / Guanylate cyclase 2G	ENSMUSG00000055523	32
Gucy2d	ENSMUSG00000074003	32
Gucy2c / Q3UWA6 / Heat-stable enterotoxin receptor / P25092* / guanylate cyclase 2C*	ENSMUSG00000042638	30
Gucy1b2	ENSMUSG00000021933	15
Gucy1a2 / guanylate cyclase 1 soluble subunit alpha 2 / P33402*	ENSMUSG00000041624	15
Q9ERL9 / Gucy1a1 / guanylate cyclase 1, soluble, alpha 1 / Q02108* / guanylate cyclase 1 soluble subunit alpha 1*	ENSMUSG00000033910	14
O54865 / Gucy1b1 / guanylate cyclase 1, soluble, beta 1 / Q02153* / guanylate cyclase 1 soluble subunit beta 1*	ENSMUSG00000028005	13

Protein motifs (from Interpro)

Interpro ID	Name
IPR000719	Protein kinase domain
IPR001054	Adenylyl cyclase class-3/4/guanylyl cyclase
IPR001170	Adenylyl cyclase class-4/guanylyl cyclase
IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
IPR001828	Receptor, ligand binding region
IPR011009	Protein kinase-like domain superfamily
IPR018297	Adenylyl cyclase class-4/guanylyl cyclase, conserved site
IPR028082	Periplasmic binding protein-like I
IPR029787	Nucleotide cyclase

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001503	ossification	IEA
biological_process	GO:0006182	cGMP biosynthetic process	IEA
biological_process	GO:0006468	protein phosphorylation	IEA
biological_process	GO:0007168	receptor guanylyl cyclase signaling pathway	IEA
biological_process	GO:0009190	cyclic nucleotide biosynthetic process	IEA
biological_process	GO:0022414	reproductive process	IMP
biological_process	GO:0035556	intracellular signal transduction	IEA
biological_process	GO:0051447	negative regulation of meiotic cell cycle	IMP
biological_process	GO:0060348	bone development	IMP
biological_process	GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus	IEA
biological_process	GO:1900194	negative regulation of oocyte maturation	IMP
cellular_component	GO:0005622	intracellular	IEA
cellular_component	GO:0005886	plasma membrane	TAS
cellular_component	GO:0005887	integral component of plasma membrane	IEA
cellular_component	GO:0008074	guanylate cyclase complex, soluble	IBA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0004383	guanylate cyclase activity	IEA
molecular_function	GO:0004672	protein kinase activity	IEA
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0005525	GTP binding	IEA
molecular_function	GO:0016829	lyase activity	IEA
molecular_function	GO:0016849	phosphorus-oxygen lyase activity	IEA
molecular_function	GO:0016941	natriuretic peptide receptor activity	IEA
molecular_function	GO:0017046	peptide hormone binding	IEA
molecular_function	GO:0042562	hormone binding	IEA
molecular_function	GO:0042802	identical protein binding	IPI

Pathways (from Reactome)

Pathway description

Physiological factors

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000097	short maxilla	"reduced length of the upper jaw bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Smad2^tm1Rob/Smad2^tm1Rob Genetic Background: involves: 129S/SvEv
MP:0000120	malocclusion	"perturbations in the normal patterned arrangement of the teeth or alignment of the jaw, resulting in the incorrect position of biting or chewing surfaces of the upper and lower teeth" [J:61509]	Show Allelic Composition: Smad2^tm1Rob/Smad2^tm1Rob Genetic Background: involves: 129S/SvEv Allelic Composition: Npr2^tm1Gar/Npr2^tm1Gar Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: Npr2^pwe/Npr2^pwe Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI
MP:0000165	abnormal hypertrophic chondrocyte zone	"anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]	Show Allelic Composition: Npr2^pwe/Npr2^pwe Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI
MP:0000166	abnormal chondrocyte morphology	"anomalous structure, organization, or differentiation of nondividing cartilage cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]	Show Allelic Composition: Eda^Ta/Y Genetic Background: B6CBACa A^w-J/A-Eda^Ta/J-XO
MP:0000428	abnormal craniofacial morphology	"anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Smad2^tm1Rob/Smad2^tm1Rob Genetic Background: involves: 129S/SvEv
MP:0000438	abnormal skull morphology	"anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cd209b^tm1Anjm/Cd209b^tm1Anjm Genetic Background: B6.129P2-Cd209b^tm1Anjm
MP:0000440	domed skull		Show Allelic Composition: Smad2^tm1Rob/Smad2^tm1Rob Genetic Background: involves: 129S/SvEv Allelic Composition: Npr2^slw/Npr2^slw Genetic Background: involves: C57BL/6 * DDY Allelic Composition: Npr2^pwe/Npr2^pwe Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI
MP:0000445	short snout	"reduced length of the anterior facial part of the muzzle" [J:53370]	Show Allelic Composition: Npr2^cn-3J/Npr2^cn-3J Genetic Background: MRL/MpJ-Npr2^cn-3J/GrsrJ Allelic Composition: Npr2^pwe/Npr2^pwe Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI
MP:0000547	short limbs	"reduced average length of the extremities" [MGI:CLS, J:61509]	Show Allelic Composition: Smad2^tm1Rob/Smad2^tm1Rob Genetic Background: involves: 129S/SvEv
MP:0000588	thick tail	"a tail with a greater diameter than the norm " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Smad2^tm1Rob/Smad2^tm1Rob Genetic Background: involves: 129S/SvEv
MP:0000592	short tail	"reduced length of tail compared to control " [J:55583]	Show Allelic Composition: Smad2^tm1Rob/Smad2^tm1Rob Genetic Background: involves: 129S/SvEv Allelic Composition: Npr2^slw/Npr2^slw Genetic Background: involves: C57BL/6 * DDY Allelic Composition: Npr2^cn-3J/Npr2^cn-3J Genetic Background: MRL/MpJ-Npr2^cn-3J/GrsrJ
MP:0000692	small spleen	"decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Smad2^tm1Rob/Smad2^tm1Rob Genetic Background: involves: 129S/SvEv
MP:0000961	abnormal dorsal root ganglia morphology	"malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]	Show Allelic Composition: Klf3^{Gt(CH0516)Wtsi}/Klf3^{Gt(CH0516)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Npr2^tm1Fgr/Npr2^tm1Fgr Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0000968	abnormal sensory neuron innervation	"defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]	Show Allelic Composition: Npr2^cn/Npr2^cn Genetic Background: involves: AKR/J
MP:0001056	abnormal cranial nerve morphology	"any anomaly, deformity, or malformation of any of the twelve nerves that emerge from the cranium as opposed to the spinal nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]	Show Allelic Composition: Klf3^{Gt(CH0516)Wtsi}/Klf3^{Gt(CH0516)Wtsi} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001065	abnormal trigeminal nerve morphology	"malformed chief sensory nerve of the face and motor nerve of the muscles of mastication; has three major divisions: ophthalmic, maxillary and mandibular " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]	Show Allelic Composition: Npr2^tm1Fgr/Npr2^tm1Fgr Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0001120	abnormal uterus morphology	"malformation or absence of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Npr2^tm1Gar/Npr2^tm1Gar Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0001127	small ovary	"reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]	Show Allelic Composition: Npr2^tm1Gar/Npr2^tm1Gar Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0001134	absent corpora lutea	"missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]	Show Allelic Composition: Npr2^tm1Gar/Npr2^tm1Gar Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0001258	decreased body length	"decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Npr2^tm1Gar/Npr2^tm1Gar Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: Npr2^slw/Npr2^slw Genetic Background: involves: C57BL/6 * DDY Allelic Composition: Npr2^pwe/Npr2^pwe Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI
MP:0001259	abnormal body weight	"anomaly in average weight compared to the norm" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Smad2^tm1Rob/Smad2^tm1Rob Genetic Background: involves: 129S/SvEv
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Smad2^tm1Rob/Smad2^tm1Rob Genetic Background: involves: 129S/SvEv Allelic Composition: Npr2^pwe/Npr2^pwe Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Cd209b^tm1Anjm/Cd209b^tm1Anjm Genetic Background: B6.129P2-Cd209b^tm1Anjm Allelic Composition: Npr2^tm1Fgr/Npr2^tm1Fgr Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0001270	distended abdomen	"abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Smad2^tm1Rob/Smad2^tm1Rob Genetic Background: involves: 129S/SvEv
MP:0001513	limb grasping	"mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Npr2^tm1Gar/Npr2^tm1Gar Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0001575	cyanosis	"a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]	Show Allelic Composition: Smad2^tm1Rob/Smad2^tm1Rob Genetic Background: involves: 129S/SvEv
MP:0001663	abnormal digestive system physiology	"altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: L1cam^tm1Sor/Y,Nrcam^tm1Gmt/Nrcam^tm1Gmt Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Swiss Webster
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Smad2^tm1Rob/Smad2^tm1Rob Genetic Background: involves: 129S/SvEv Allelic Composition: Npr2^tm1Gar/Npr2^tm1Gar Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: Npr2^pwe/Npr2^pwe Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI
MP:0001921	reduced fertility	"diminished ability to produce live offspring" [J:65030]	Show Allelic Composition: Smad2^tm1Rob/Smad2^tm1Rob Genetic Background: involves: 129S/SvEv Allelic Composition: Npr2^cn-3J/Npr2^cn-3J Genetic Background: MRL/MpJ-Npr2^cn-3J/GrsrJ
MP:0001922	reduced male fertility	"reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]	Show Allelic Composition: Npr2^pwe/Npr2^pwe Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI
MP:0001926	female infertility	"inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]	Show Allelic Composition: Npr2^tm1Gar/Npr2^tm1Gar Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: Npr2^pwe/Npr2^pwe Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI
MP:0001931	abnormal oogenesis	"atypical formation or failure to form the female germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]	Show Allelic Composition: Npr2^pwe/Npr2^pwe Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI
MP:0001935	reduced litter size	"fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Npr2^cn-3J/Npr2^cn-3J Genetic Background: MRL/MpJ-Npr2^cn-3J/GrsrJ
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Smad2^tm1Rob/Smad2^tm1Rob Genetic Background: involves: 129S/SvEv Allelic Composition: Npr2^tm1Gar/Npr2^tm1Gar Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0002089	abnormal postnatal growth/weight/body size	"increased or decreased average body size, weight or growth characteristic abnormalities manifesting after birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Smad2^tm1Rob/Smad2^tm1Rob Genetic Background: involves: 129S/SvEv
MP:0002113	abnormal skeleton development	"anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Npr2^tm1Gar/Npr2^tm1Gar Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: Npr2^cn/Npr2^cn Genetic Background: involves: AKR/J
MP:0002114	abnormal axial skeleton morphology	"abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Smad2^tm1Rob/Smad2^tm1Rob Genetic Background: involves: 129S/SvEv
MP:0002128	abnormal blood circulation	"failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Smad2^tm1Rob/Smad2^tm1Rob Genetic Background: involves: 129S/SvEv
MP:0002233	abnormal nose morphology	"any structural anomaly of the organ that is specialized for smell and is part of the respiratory system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Smad2^tm1Rob/Smad2^tm1Rob Genetic Background: involves: 129S/SvEv
MP:0002427	dwarfism	"abnormally undersized with disproportionate body parts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: L1cam^tm1Sor/Y,Nrcam^tm1Gmt/Nrcam^tm1Gmt Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Swiss Webster Allelic Composition: Npr2^cn/Npr2^slw Genetic Background: involves: AKR/J * C57BL/6 * DDY Allelic Composition: Npr2^cn-3J/Npr2^cn-3J Genetic Background: MRL/MpJ-Npr2^cn-3J/GrsrJ Allelic Composition: Npr2^pwe/Npr2^pwe Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI
MP:0002544	brachydactyly	"abnormally short digits" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Smad2^tm1Rob/Smad2^tm1Rob Genetic Background: involves: 129S/SvEv
MP:0002636	delayed vaginal opening	"the opening of the genital canal in a female occuring at a later than expected age" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Npr2^pwe/Npr2^pwe Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI
MP:0002637	small uterus	"reduced size of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Npr2^tm1Gar/Npr2^tm1Gar Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0002657	chondrodystrophy	"abnormal development of the cartilage primordia of long bones, resulting in abnormally short extremities but normal head and trunk" [il:Ira Lu , Mouse Genome Informatics Curator]	Show Allelic Composition: Npr2^slw/Npr2^slw Genetic Background: involves: C57BL/6 * DDY
MP:0002764	short tibia	" reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Smad2^tm1Rob/Smad2^tm1Rob Genetic Background: involves: 129S/SvEv
MP:0003055	abnormal epiphyseal plate morphology	"malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Smad2^tm1Rob/Smad2^tm1Rob Genetic Background: involves: 129S/SvEv Allelic Composition: Npr2^cn/Npr2^cn Genetic Background: Not Specified Allelic Composition: Npr2^pwe/Npr2^pwe Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI
MP:0003109	short femur	"reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Smad2^tm1Rob/Smad2^tm1Rob Genetic Background: involves: 129S/SvEv Allelic Composition: Npr2^cn-2J/Npr2^cn-2J Genetic Background: B6;CBACa-A^w-J/A-Kcnj6^wv/+ Allelic Composition: Npr2^pwe/Npr2^pwe Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI
MP:0003157	impaired muscle relaxation	"reduced or absent ability of muscle to lengthen following contractions" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92510]	Show Allelic Composition: Npr2^slw/Npr2^slw Genetic Background: involves: C57BL/6 * DDY
MP:0003409	decreased width of hypertrophic chondrocyte zone	"decreased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Smad2^tm1Rob/Smad2^tm1Rob Genetic Background: involves: 129S/SvEv Allelic Composition: Npr2^tm1Gar/Npr2^tm1Gar Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0003662	abnormal proliferative zone	"germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]	Show Allelic Composition: Smad2^tm1Rob/Smad2^tm1Rob Genetic Background: involves: 129S/SvEv Allelic Composition: Npr2^pwe/Npr2^pwe Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI
MP:0004340	short scapula	"reduced length of either or both of the large, flat bones of the back part of the shoulder" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Smad2^tm1Rob/Smad2^tm1Rob Genetic Background: involves: 129S/SvEv
MP:0004351	short humerus	"reduced length of one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Smad2^tm1Rob/Smad2^tm1Rob Genetic Background: involves: 129S/SvEv Allelic Composition: Npr2^pwe/Npr2^pwe Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI
MP:0004355	short radius	"reduced length of the short bone of the lateral forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Smad2^tm1Rob/Smad2^tm1Rob Genetic Background: involves: 129S/SvEv
MP:0004359	short ulna	"reduced length of the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Smad2^tm1Rob/Smad2^tm1Rob Genetic Background: involves: 129S/SvEv
MP:0004386	enlarged interparietal bone	"increased size of the bone of the cranium that lies above and anterior to the occipital bone in some mammals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npr2^slw/Npr2^slw Genetic Background: involves: C57BL/6 * DDY
MP:0004421	enlarged parietal bone	"increased size of the curved bone forming part of the vault of the cranium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npr2^slw/Npr2^slw Genetic Background: involves: C57BL/6 * DDY
MP:0004444	small supraoccipital bone	"reduced size of the bone on the dorsal side of the great foramen of the skull, usually forming a part of the occipital in the adult, but distinct in the young" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npr2^slw/Npr2^slw Genetic Background: involves: C57BL/6 * DDY
MP:0004470	small nasal bone	"reduced size of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Npr2^slw/Npr2^slw Genetic Background: involves: C57BL/6 * DDY
MP:0004509	abnormal pelvic girdle bone morphology	"any structural anomaly of the bones of the pelvis by which the limbs attach to the axial skeleton " [MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Smad2^tm1Rob/Smad2^tm1Rob Genetic Background: involves: 129S/SvEv
MP:0004595	abnormal mandibular condyloid process morphology	"any structural anomaly of the round bump of bone and constricted neck portion that arises from the upper surface of the mandibular ramus (perpendicular portion) and articulates with the articular disk of the temporomandibular joint" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npr2^cn/Npr2^cn Genetic Background: Not Specified
MP:0004607	abnormal cervical atlas morphology	"any structural anomaly of the first (topmost, C1) cervical vertebra which supports the globe of the head" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npr2^pwe/Npr2^pwe Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI
MP:0004673	splayed ribs	"any deviation from the normal curvature of the ribs such that the ribs are turned outward " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npr2^cn-2J/Npr2^cn-2J Genetic Background: B6;CBACa-A^w-J/A-Kcnj6^wv/+
MP:0004686	decreased length of long bones	"reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Smad2^tm1Rob/Smad2^tm1Rob Genetic Background: involves: 129S/SvEv
MP:0004704	short vertebral column	"decreased rostral-caudal length of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Smad2^tm1Rob/Smad2^tm1Rob Genetic Background: involves: 129S/SvEv
MP:0004831	long incisors	"increased length of the long pointed teeth; most anterior and prominent in the jaw" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npr2^tm1Gar/Npr2^tm1Gar Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0005168	abnormal female meiosis	"malfunction in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Fzd2^tm1.1Nat/Fzd2^tm1.1Nat,Vangl2^Lp/Vangl2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * LPT/LeJ
MP:0006396	decreased long bone epiphyseal plate size	"reduced size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Smad2^tm1Rob/Smad2^tm1Rob Genetic Background: involves: 129S/SvEv Allelic Composition: Npr2^tm1Gar/Npr2^tm1Gar Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0006397	disorganized long bone epiphyseal plate	"a lack of the regular arrangement of the cells or zones of the epiphyseal plate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npr2^cn-2J/Npr2^cn-2J Genetic Background: B6;CBACa-A^w-J/A-Kcnj6^wv/+
MP:0008158	increased diameter of femur	"increased width of the cross-sectional distance that extends from one lateral edge of the femur, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npr2^cn-2J/Npr2^cn-2J Genetic Background: B6;CBACa-A^w-J/A-Kcnj6^wv/+
MP:0008257	thin myometrium	"reduced thickness of the smooth muscle coat of the uterus, which forms the main mass of the organ and surrounds and supports the endometrium" [MESH:A02.633.570.500, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npr2^tm1Gar/Npr2^tm1Gar Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0008258	thin endometrium	"reduced thickness of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy" [MESH:A05.360.319.679.490, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npr2^tm1Gar/Npr2^tm1Gar Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0008272	abnormal endochondral bone ossification	"anomaly in the process of the formation of bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958]	Show Allelic Composition: Npr2^slw/Npr2^slw Genetic Background: involves: C57BL/6 * DDY Allelic Composition: Npr2^pwe/Npr2^pwe Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI
MP:0008526	decreased skull width	"having a decreased side-to-side distance of the skull" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Smad2^tm1Rob/Smad2^tm1Rob Genetic Background: involves: 129S/SvEv
MP:0008736	micromelia	"disproportionately short or small limbs" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npr2^cn-3J/Npr2^cn-3J Genetic Background: MRL/MpJ-Npr2^cn-3J/GrsrJ
MP:0008770	decreased survivor rate	"a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npr2^pwe/Npr2^pwe Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI
MP:0009009	absent estrous cycle	"failure of female animals to enter or progress through their sexual cycle" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npr2^tm1Gar/Npr2^tm1Gar Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0009088	thin uterine horn	"reduced thickness of either one of the pair of tubular extensions from the uterine body where the uterus and the uterine tubes meet" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npr2^tm1Gar/Npr2^tm1Gar Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0009247	meteorism	"swelling of the abdomen resulting from gas in the intestinal or peritoneal cavity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npr2^slw/Npr2^slw Genetic Background: involves: C57BL/6 * DDY
MP:0009677	abnormal spinal cord dorsal column morphology	"any structural anomaly of the wedge-shaped fiber bundle of white matter in the dorsomedial side of the spinal cord that is made up of the fasciculus gracilis and fasciculus cuneatus; it is part of the ascending posterior column-medial lemniscus pathway that is important for well-localized fine touch and conscious proprioception" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN-10:0940780577 "Goldberg, S, Clinical Neuroanatomy Made Ridiculously Simple, 3rd edition"]	Show Allelic Composition: Npr2^cn/Npr2^cn Genetic Background: involves: AKR/J
MP:0009854	delayed gastric emptying	"an increase in the time required for solids or liquids to leave the stomach and enter the intestines" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npr2^slw/Npr2^slw Genetic Background: involves: C57BL/6 * DDY
MP:0009861	abnormal pyloric sphincter morphology	"any structural anomaly of the thick circular layer of gastric musculature encircling the gastroduodenal junction at the gastric outlet of the stomach" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Npr2^slw/Npr2^slw Genetic Background: involves: C57BL/6 * DDY
MP:0010029	abnormal basicranium morphology	"any structural anomaly of the sloping floor of the cranial cavity that is comprised of parts of the ethmoidal, occipital and sphenoid bones" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Npr2^cn/Npr2^cn Genetic Background: Not Specified
MP:0010155	abnormal intestine physiology	"any functional anomaly of the digestive tube passing from the stomach to the anus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npr2^slw/Npr2^slw Genetic Background: involves: C57BL/6 * DDY
MP:0010867	abnormal bone trabecula morphology	"any structural anomaly of the network of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Smad2^tm1Rob/Smad2^tm1Rob Genetic Background: involves: 129S/SvEv
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Smad2^tm1Rob/Smad2^tm1Rob Genetic Background: involves: 129S/SvEv Allelic Composition: Npr2^slw/Npr2^slw Genetic Background: involves: C57BL/6 * DDY
MP:0011102	partial embryonic lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]	Show Allelic Composition: Npr2^slw/Npr2^slw Genetic Background: involves: C57BL/6 * DDY
MP:0011862	decreased cranium length	"having an decreased dorsal-to-ventral distance of the cranium" [MGI:mnk]	Show Allelic Composition: Smad2^tm1Rob/Smad2^tm1Rob Genetic Background: involves: 129S/SvEv
MP:0030082	long lower incisors	"increased length or overgrowth of the lower set of long teeth that are the most anterior and prominent in the jaw" [MGI:anna]	Show Allelic Composition: Npr2^tm1Gar/Npr2^tm1Gar Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0030083	long upper incisors	"increased length or overgrowth of the upper set of long teeth that are the most anterior and prominent in the jaw" [MGI:anna]	Show Allelic Composition: Npr2^tm1Gar/Npr2^tm1Gar Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0030245	round head	"overall shape of the head is more circular than usual as viewed from the front" [MGI:anna]	Show Allelic Composition: Npr2^cn-2J/Npr2^cn-2J Genetic Background: B6;CBACa-A^w-J/A-Kcnj6^wv/+

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000026241	Nppc / Q61839 / natriuretic peptide type C / P23582* / natriuretic peptide C*	/ complex / reaction

0 s.

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