ENSMUSG00000033910


Mus musculus

Features
Gene ID: ENSMUSG00000033910
  
Biological name :Gucy1a1
  
Synonyms : guanylate cyclase 1, soluble, alpha 1 / Gucy1a1 / Q9ERL9
  
Possible biological names infered from orthology : guanylate cyclase 1 soluble subunit alpha 1 / Q02108
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: E3
Gene start: 82092427
Gene end: 82145789
  
Corresponding Affymetrix probe sets: 10498952 (MoGene1.0st)   1420533_at (Mouse Genome 430 2.0 Array)   1420534_at (Mouse Genome 430 2.0 Array)   1434141_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000048918
Ensembl peptide - ENSMUSP00000141478
Ensembl peptide - ENSMUSP00000142138
NCBI entrez gene - 60596     See in Manteia.
MGI - MGI:1926562
RefSeq - XM_011240184
RefSeq - NM_001356987
RefSeq - NM_001356988
RefSeq - NM_021896
RefSeq - XM_006501843
RefSeq Peptide - NP_001343917
RefSeq Peptide - NP_068696
RefSeq Peptide - NP_001343916
swissprot - Q9ERL9
swissprot - A0A0A6YWB4
Ensembl - ENSMUSG00000033910
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gucy1a1ENSDARG00000013787Danio rerio
 GUCY1A1ENSGALG00000035946Gallus gallus
 Q02108ENSG00000164116Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gucy1a2 / guanylate cyclase 1 soluble subunit alpha 2 / P33402*ENSMUSG0000004162449
O54865 / Gucy1b1 / guanylate cyclase 1, soluble, beta 1 / Q02153* / guanylate cyclase 1 soluble subunit beta 1*ENSMUSG0000002800528
Gucy2e / P52785 / Guanylyl cyclase GC-E / GUCY2D* / Q02846* / guanylate cyclase 2D, retinal*ENSMUSG0000002089024
Gucy1b2ENSMUSG0000002193324
Gucy2dENSMUSG0000007400323
Gucy2f / Q5SDA5 / Retinal guanylyl cyclase 2 / P51841* / guanylate cyclase 2F, retinal*ENSMUSG0000004228223
Gucy2c / Q3UWA6 / Heat-stable enterotoxin receptor / P25092* / guanylate cyclase 2C*ENSMUSG0000004263822
Npr2 / Q6VVW5 / natriuretic peptide receptor 2 / P20594*ENSMUSG0000002846922
Npr1 / P18293 / natriuretic peptide receptor 1 / P16066*ENSMUSG0000002793122
Gucy2g / Q6TL19 / Guanylate cyclase 2G ENSMUSG0000005552321


Protein motifs (from Interpro)
Interpro ID Name
 IPR001054  Adenylyl cyclase class-3/4/guanylyl cyclase
 IPR011645  Haem NO binding associated
 IPR018297  Adenylyl cyclase class-4/guanylyl cyclase, conserved site
 IPR024096  NO signalling/Golgi transport ligand-binding domain superfamily
 IPR029787  Nucleotide cyclase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006182 cGMP biosynthetic process ISO
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0008217 regulation of blood pressure IMP
 biological_processGO:0009190 cyclic nucleotide biosynthetic process IEA
 biological_processGO:0030828 obsolete positive regulation of cGMP biosynthetic process IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0052565 response to defense-related host nitric oxide production IMP
 biological_processGO:0060087 relaxation of vascular smooth muscle IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0008074 guanylate cyclase complex, soluble ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004383 guanylate cyclase activity IBA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0016849 phosphorus-oxygen lyase activity IEA
 molecular_functionGO:0020037 heme binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000276 right ventricle hypertrophy "increased size of the right ventricle" [J:33629]
Show

Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0001330 abnormal optic nerve morphology "malformation, misprojection or atrophy in the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hfetm1.1Jrco/Hfe+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001613 abnormal vasodilation "anomalous widening of the lumen of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cnbpm1Hrb/Cnbp+
Genetic Background: B6.129S4-Cnbpm1Hrb

 MP:0002842 increased blood pressure "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0004007 abnormal lung vasculature "malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0005206 abnormal aqueous humor "anomaly in the clear, watery fluid that fills the anterior and posterior chambers of the eye" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hfetm1.1Jrco/Hfe+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005253 abnormal eye physiology "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hfetm1.1Jrco/Hfe+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005258 ocular hypertension "abnormal elevation of the intraocular pressure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hfetm1.1Jrco/Hfe+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cnbpm1Hrb/Cnbp+
Genetic Background: B6.129S4-Cnbpm1Hrb

 MP:0006303 abnormal retinal nerve fiber layer morphology "malformation of the layer of the retina formed by expansion of the fibers of the optic nerve" [ISBN:0-914294-08-3 "Gray s Anatomy", J:67382, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hfetm1.1Jrco/Hfe+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0006309 decreased retinal ganglion cell number "reduced number of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hfetm1.1Jrco/Hfe+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0009548 abnormal platelet aggregation "any functional anomaly in the adhesion of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
Show

Allelic Composition: Cnbpm1Hrb/Cnbp+
Genetic Background: B6.129S4-Cnbpm1Hrb

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Acancmd-Bc/Acancmd-Bc
Genetic Background: BALB/cGaBc

 MP:0010755 abnormal heart right ventricle pressure "any anomaly in the pressure within the right cardiac ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tshz3tm1Lafa/Tshz3+
Genetic Background: involves: 129P2/OlaHsd * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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