ENSMUSG00000028005


Mus musculus

Features
Gene ID: ENSMUSG00000028005
  
Biological name :Gucy1b1
  
Synonyms : guanylate cyclase 1, soluble, beta 1 / Gucy1b1 / O54865
  
Possible biological names infered from orthology : guanylate cyclase 1 soluble subunit beta 1 / Q02153
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: E3
Gene start: 82032006
Gene end: 82074689
  
Corresponding Affymetrix probe sets: 10498935 (MoGene1.0st)   1420871_at (Mouse Genome 430 2.0 Array)   1420872_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029635
Ensembl peptide - ENSMUSP00000142119
NCBI entrez gene - 54195     See in Manteia.
MGI - MGI:1860604
RefSeq - NM_017469
RefSeq - NM_001161796
RefSeq Peptide - NP_001155268
RefSeq Peptide - NP_059497
swissprot - O54865
swissprot - Q80YP4
Ensembl - ENSMUSG00000028005
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gucy1b1ENSDARG00000086790Danio rerio
 GUCY1B1ENSGALG00000009361Gallus gallus
 Q02153ENSG00000061918Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gucy1a2 / guanylate cyclase 1 soluble subunit alpha 2 / P33402*ENSMUSG0000004162436
Q9ERL9 / Gucy1a1 / guanylate cyclase 1, soluble, alpha 1 / Q02108* / guanylate cyclase 1 soluble subunit alpha 1*ENSMUSG0000003391032
Gucy1b2ENSMUSG0000002193328
Npr1 / P18293 / natriuretic peptide receptor 1 / P16066*ENSMUSG0000002793124
Gucy2f / Q5SDA5 / Retinal guanylyl cyclase 2 / P51841* / guanylate cyclase 2F, retinal*ENSMUSG0000004228223
Npr2 / Q6VVW5 / natriuretic peptide receptor 2 / P20594*ENSMUSG0000002846923
Gucy2dENSMUSG0000007400323
Gucy2e / P52785 / Guanylyl cyclase GC-E / GUCY2D* / Q02846* / guanylate cyclase 2D, retinal*ENSMUSG0000002089022
Gucy2c / Q3UWA6 / Heat-stable enterotoxin receptor / P25092* / guanylate cyclase 2C*ENSMUSG0000004263821
Gucy2g / Q6TL19 / Guanylate cyclase 2G ENSMUSG0000005552321


Protein motifs (from Interpro)
Interpro ID Name
 IPR001054  Adenylyl cyclase class-3/4/guanylyl cyclase
 IPR011644  Heme NO-binding
 IPR011645  Haem NO binding associated
 IPR018297  Adenylyl cyclase class-4/guanylyl cyclase, conserved site
 IPR024096  NO signalling/Golgi transport ligand-binding domain superfamily
 IPR029787  Nucleotide cyclase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006182 cGMP biosynthetic process IEA
 biological_processGO:0007263 nitric oxide mediated signal transduction IEA
 biological_processGO:0009190 cyclic nucleotide biosynthetic process IEA
 biological_processGO:0019934 cGMP-mediated signaling IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0038060 nitric oxide-cGMP-mediated signaling pathway ISS
 biological_processGO:0071732 cellular response to nitric oxide ISS
 biological_processGO:0099555 trans-synaptic signaling by nitric oxide, modulating synaptic transmission IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0008074 guanylate cyclase complex, soluble IEA
 cellular_componentGO:0048786 presynaptic active zone IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004383 guanylate cyclase activity IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0016849 phosphorus-oxygen lyase activity IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0043167 ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0047805 cytidylate cyclase activity IEA
 molecular_functionGO:0051879 Hsp90 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000230 abnormal blood pressure "altered tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: KitW-sh/KitW-v
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Gucy1b1tm1.2Frb/Gucy1b1tm1.2Frb,X/Tg(Myh11-cre/ERT2)1Soff
Genetic Background: B6.Cg-Gucy1b1tm1.2Frb Tg(Myh11-cre/ERT2)1Soff

 MP:0000231 hypertension "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gucy1b1tm1.2Frb/Gucy1b1tm1.2Frb,X/Tg(Myh11-cre/ERT2)1Soff
Genetic Background: B6.Cg-Gucy1b1tm1.2Frb Tg(Myh11-cre/ERT2)1Soff

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
Show

Allelic Composition: KitW-sh/KitW-v
Genetic Background: involves: 101/H * C3H/HeH

 MP:0000494 abnormal cecum morphology "malformation of the large sac at the ileum and large intestine junction" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: KitW-sh/KitW-v
Genetic Background: involves: 101/H * C3H/HeH

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: KitW-sh/KitW-v
Genetic Background: involves: 101/H * C3H/HeH

 MP:0001613 abnormal vasodilation "anomalous widening of the lumen of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: KitW-sh/KitW-v
Genetic Background: involves: 101/H * C3H/HeH

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: KitW-sh/KitW-v
Genetic Background: involves: 101/H * C3H/HeH

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: KitW-sh/KitW-v
Genetic Background: involves: 101/H * C3H/HeH

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sh3kbp1tm1Kuro/Sh3kbp1tm1Kuro,Cd79atm1(cre)Reth/Cd79a+,Gt(ROSA)26Sortm4(Ikbkb)Rsky/?
Genetic Background: involves: BALB/c * C57BL/6 * NZB

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sh3kbp1tm1Kuro/Sh3kbp1tm1Kuro,Cd79atm1(cre)Reth/Cd79a+,Gt(ROSA)26Sortm4(Ikbkb)Rsky/?
Genetic Background: involves: BALB/c * C57BL/6 * NZB

 MP:0003290 hypoperistalsis "reduced intestinal movement characterized by waves of alternate circular contraction and relaxation of the muscular walls of the bowel that move bowel contents forward" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: KitW-sh/KitW-v
Genetic Background: involves: 101/H * C3H/HeH

 MP:0003303 peritoneal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the membrane that lines the abdominal cavity and covers most of the viscera" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: KitW-sh/KitW-v
Genetic Background: involves: 101/H * C3H/HeH

 MP:0003883 enlarged stomach "increased size of the stomach" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: KitW-sh/KitW-v
Genetic Background: involves: 101/H * C3H/HeH

 MP:0004548 dilated esophagus "an expansion in the lumen volume of the part of the digestive canal through which food passes from the pharynx to the stomach" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: KitW-sh/KitW-v
Genetic Background: involves: 101/H * C3H/HeH

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Sh3kbp1tm1Kuro/Sh3kbp1tm1Kuro,Cd79atm1(cre)Reth/Cd79a+,Gt(ROSA)26Sortm4(Ikbkb)Rsky/?
Genetic Background: involves: BALB/c * C57BL/6 * NZB

 MP:0005591 decreased vasodilation "less than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gucy1b1tm1.2Frb/Gucy1b1tm1.2Frb,X/Tg(Myh11-cre/ERT2)1Soff
Genetic Background: B6.Cg-Gucy1b1tm1.2Frb Tg(Myh11-cre/ERT2)1Soff

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Sh3kbp1tm1Kuro/Sh3kbp1tm1Kuro,Cd79atm1(cre)Reth/Cd79a+,Gt(ROSA)26Sortm4(Ikbkb)Rsky/?
Genetic Background: involves: BALB/c * C57BL/6 * NZB

 MP:0006001 abnormal intestinal transit time "increase or decrease in the time it takes for a bolus of material to pass through the intestine" [smb:Susan M Bello, Mouse Genome Iformatics Curator]
Show

Allelic Composition: KitW-sh/KitW-v
Genetic Background: involves: 101/H * C3H/HeH

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: KitW-sh/KitW-v
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Gucy1b1tm1.2Frb/Gucy1b1tm1.2Frb,X/Tg(Myh11-cre/ERT2)1Soff
Genetic Background: B6.Cg-Gucy1b1tm1.2Frb Tg(Myh11-cre/ERT2)1Soff

 MP:0006298 abnormal platelet activation "anomaly in the series of progressive, overlapping events triggered by exposure of platelets to signals from subendothelial tissue, including shape change, adhesiveness, aggregation, and release reactions; when carried through to completion, these events lead to the formation of a stable hemostatic plug" [GO:0030168, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: KitW-sh/KitW-v
Genetic Background: involves: 101/H * C3H/HeH

 MP:0009343 dilated gall bladder "abnormal distention of the gall bladder due to accumulation of fluid or bile" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: KitW-sh/KitW-v
Genetic Background: involves: 101/H * C3H/HeH

 MP:0009476 enlarged cecum "increased size of the large sac at the ileum and large intestine junction" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: KitW-sh/KitW-v
Genetic Background: involves: 101/H * C3H/HeH

 MP:0009480 distended cecum "an expansion in the volume of the large sac at the ileum and large intestine junction, as by stretching or distention" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: KitW-sh/KitW-v
Genetic Background: involves: 101/H * C3H/HeH

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
Show

Allelic Composition: Sh3kbp1tm1Kuro/Sh3kbp1tm1Kuro,Cd79atm1(cre)Reth/Cd79a+,Gt(ROSA)26Sortm4(Ikbkb)Rsky/?
Genetic Background: involves: BALB/c * C57BL/6 * NZB

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: KitW-sh/KitW-v
Genetic Background: involves: 101/H * C3H/HeH

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: KitW-sh/KitW-v
Genetic Background: involves: 101/H * C3H/HeH

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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