ENSG00000169418


Homo sapiens

Features
Gene ID: ENSG00000169418
  
Biological name :NPR1
  
Synonyms : natriuretic peptide receptor 1 / NPR1 / P16066
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q21.3
Gene start: 153678637
Gene end: 153693992
  
Corresponding Affymetrix probe sets: 204648_at (Human Genome U133 Plus 2.0 Array)   32625_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000357669
NCBI entrez gene - 4881     See in Manteia.
OMIM - 108960
RefSeq - XM_005245218
RefSeq - NM_000906
RefSeq Peptide - NP_000897
swissprot - P16066
swissprot - A0A140VJE6
Ensembl - ENSG00000169418
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 npr1aENSDARG00000031751Danio rerio
 npr1bENSDARG00000018750Danio rerio
 Npr1ENSMUSG00000027931Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NPR2 / P20594 / natriuretic peptide receptor 2ENSG0000015989960
GUCY2F / P51841 / guanylate cyclase 2F, retinalENSG0000010189033
GUCY2D / Q02846 / guanylate cyclase 2D, retinalENSG0000013251832
GUCY2C / P25092 / guanylate cyclase 2CENSG0000007001929
P33402 / GUCY1A2 / guanylate cyclase 1 soluble subunit alpha 2ENSG0000015240216
Q02108 / GUCY1A1 / guanylate cyclase 1 soluble subunit alpha 1ENSG0000016411615
Q02153 / GUCY1B1 / guanylate cyclase 1 soluble subunit beta 1ENSG0000006191814


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001054  Adenylyl cyclase class-3/4/guanylyl cyclase
 IPR001170  Adenylyl cyclase class-4/guanylyl cyclase
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001828  Receptor, ligand binding region
 IPR011009  Protein kinase-like domain superfamily
 IPR018297  Adenylyl cyclase class-4/guanylyl cyclase, conserved site
 IPR028082  Periplasmic binding protein-like I
 IPR029787  Nucleotide cyclase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006182 cGMP biosynthetic process IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007166 cell surface receptor signaling pathway NAS
 biological_processGO:0007168 receptor guanylyl cyclase signaling pathway IDA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007589 body fluid secretion TAS
 biological_processGO:0008217 regulation of blood pressure NAS
 biological_processGO:0009190 cyclic nucleotide biosynthetic process IEA
 biological_processGO:0016525 negative regulation of angiogenesis TAS
 biological_processGO:0030308 negative regulation of cell growth NAS
 biological_processGO:0030828 obsolete positive regulation of cGMP biosynthetic process IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0035810 positive regulation of urine volume TAS
 biological_processGO:0035815 positive regulation of renal sodium excretion TAS
 biological_processGO:0042417 dopamine metabolic process IEA
 biological_processGO:0043114 regulation of vascular permeability TAS
 biological_processGO:0048662 negative regulation of smooth muscle cell proliferation IEA
 biological_processGO:0050880 regulation of blood vessel size IEA
 biological_processGO:0097746 regulation of blood vessel diameter NAS
 biological_processGO:1903779 regulation of cardiac conduction TAS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0008074 guanylate cyclase complex, soluble IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004383 guanylate cyclase activity IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0008528 G-protein coupled peptide receptor activity NAS
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0016849 phosphorus-oxygen lyase activity IEA
 molecular_functionGO:0016941 natriuretic peptide receptor activity IDA
 molecular_functionGO:0017046 peptide hormone binding IPI
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0042562 hormone binding IPI


Pathways (from Reactome)
Pathway description
Physiological factors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000175206 NPPA / P01160 / natriuretic peptide A  / complex / reaction
 ENSG00000169418 NPR1 / P16066 / natriuretic peptide receptor 1  / complex






 

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