ENSMUSG00000041777


Mus musculus

Features
Gene ID: ENSMUSG00000041777
  
Biological name :Cir1
  
Synonyms : Cir1 / Corepressor interacting with RBPJ 1 / Q9DA19
  
Possible biological names infered from orthology : Q86X95
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: C3
Gene start: 73283105
Gene end: 73312701
  
Corresponding Affymetrix probe sets: 10483667 (MoGene1.0st)   10521589 (MoGene1.0st)   1423375_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000049834
NCBI entrez gene - 66935     See in Manteia.
MGI - MGI:1914185
RefSeq - NM_025854
RefSeq Peptide - NP_080130
swissprot - Q9DA19
Ensembl - ENSMUSG00000041777
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CIR1ENSDARG00000099733Danio rerio
 CIR1ENSGALG00000014276Gallus gallus
 CIR1ENSG00000138433Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR019339  CBF1-interacting co-repressor CIR, N-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 cellular_componentGO:0000118 histone deacetylase complex IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016607 nuclear speck ISO
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0042826 histone deacetylase binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000140 absent pedicles "loss of part of the posteriorlateral vertebral arch of a thoracic vertebrae" [J:62022, J:62023]
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust
Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust

 MP:0000153 rib bifurcation "forking or division of ribs, may be a result of partial rib fusions" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust
Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust

 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust
Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust

 MP:0000161 scoliosis "lateral and rotational curvature of the spine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53770, J:66943]
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust
Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust

 MP:0000273 overriding aorta "congenitally mispositioned aorta where the origin straddles the ventral septum and so receives ejected blood from the right ventricle as well as the left." [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:67826]
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust
Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust

 MP:0000297 abnormal endocardial cushion morphology "malformation of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust
Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust

 MP:0000489 abnormal large intestine morphology "structural or developmental anomalies of the intestinum crassum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust
Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust

 MP:0000534 abnormal ureter morphology "anomalous structure of the tube that conducts the urine from the renal pelvis to the bladder" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust
Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust

 MP:0000681 abnormal thyroid gland morphology "anomalous structure of the endocrine gland located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust
Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust
Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust
Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust
Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust

 MP:0003686 abnormal eye muscle morphology "malformation of the muscles of the eye" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust
Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust

 MP:0003826 abnormal Mullerian duct morphology "malformation of the transient embryonic tubes that empty into the cloaca and in the female develop into the oviducts, uterus, and vagina" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust
Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust

 MP:0003827 abnormal Wolffian duct morphology "malformation of the transient embryonic tubes that empty into the cloca and degenerate in the male " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust
Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust

 MP:0004269 abnormal optic cup morphology "any structural anomaly of double walled stuctured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust
Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust

 MP:0004442 occipital bone foramen "presence of a hole in the bone at the lower, posterior part of the skull" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust
Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust

 MP:0004613 fusion of vertebral arches "improper union of the dorsal part of adjacent vertebra" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust
Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust

 MP:0004646 decreased cervical vertebrae number "reduced number of the seven bony segments of the spine located anterior to the thoracic vertebrae and caudal to the skull" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust
Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust

 MP:0010418 perimembraneous ventricular septal defect "abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust
Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust

 MP:0010602 abnormal pulmonary valve cusp morphology "any structural anomaly of the three fibrous triangular components and associated flap of the pulmonary valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust
Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust

 MP:0013836 abnormal hypoglossal nerve topology "abnormal position of the hypoglossal nerve " [MGI:csmith]
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust
Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust

 MP:0013848 subcutaneous edema "accumulation of watery or serous fluid in the subcutaneous region below the skin" [MGI:csmith]
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust
Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust

 MP:0013913 absent rib-vertebral column attachment "one or more ribs are not connected to vertebra, where this connection is normally made" [MGI:csmith]
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust
Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust

 MP:0013914 absent intracranial segment of vertebral artery 
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust
Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust

 MP:0013968 multiple persisting craniopharyngeal ducts 
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust
Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust

 MP:0014003 additional anastomosis between intracranial vertebral arteries 
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust
Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust

 MP:0014021 heterochrony 
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Allelic Composition: Esr2tm1.1Gust/Esr2tm1.1Gust
Genetic Background: B6J.129X1(Cg)-Esr2tm1.1Gust

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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