ENSMUSG00000042275


Mus musculus

Features
Gene ID: ENSMUSG00000042275
  
Biological name :Pelo
  
Synonyms : Pelo / pelota mRNA surveillance and ribosome rescue factor / Q80X73
  
Possible biological names infered from orthology : Q9BRX2
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: D2.2
Gene start: 115088355
Gene end: 115090186
  
Corresponding Affymetrix probe sets: 10412328 (MoGene1.0st)   1434071_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000104849
NCBI entrez gene - 105083     See in Manteia.
MGI - MGI:2145154
RefSeq - NM_134058
RefSeq Peptide - NP_598819
swissprot - Q80X73
Ensembl - ENSMUSG00000042275
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 peloENSDARG00000055477Danio rerio
 PELOENSGALG00000034847Gallus gallus
 PELOENSG00000152684Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004405  Translation release factor pelota
 IPR005140  eRF1 domain 1/Pelota-like
 IPR005141  eRF1 domain 2
 IPR005142  eRF1 domain 3
 IPR029064  50S ribosomal protein L30e-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006412 translation IBA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007492 endoderm development IMP
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0019827 stem cell population maintenance IMP
 biological_processGO:0030513 positive regulation of BMP signaling pathway IMP
 biological_processGO:0032790 ribosome disassembly IBA
 biological_processGO:0051276 chromosome organization IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:0060231 mesenchymal to epithelial transition IMP
 biological_processGO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay IEA
 biological_processGO:0070651 nonfunctional rRNA decay IBA
 biological_processGO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay IBA
 biological_processGO:0071025 RNA surveillance IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0043022 ribosome binding IBA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001674 abnormal triploblastic development "abnormal development of the three primary germ layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: DctSlt-lt3J/Dct+
Genetic Background: B6(Cg)-DctSlt-lt3J/J

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: DctSlt-lt3J/Dct+
Genetic Background: B6(Cg)-DctSlt-lt3J/J

 MP:0001724 abnormal extraembryonic endoderm formation "malformation of the endoderm of the extraembryonic tissue that appears prior to gastrulation and performs critical functions during embryogenesis including nutrient uptake and transport from the mother to the embryo" [J:62628]
Show

Allelic Composition: DctSlt-lt3J/Dct+
Genetic Background: B6(Cg)-DctSlt-lt3J/J

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: DctSlt-lt3J/Dct+
Genetic Background: B6(Cg)-DctSlt-lt3J/J

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: DctSlt-lt3J/Dct+
Genetic Background: B6(Cg)-DctSlt-lt3J/J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pcdhgtm2Xzw/Pcdhgtm2Xzw,Robo2tm1Rilm/Robo2tm1Rilm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: DctSlt-lt3J/Dct+
Genetic Background: B6(Cg)-DctSlt-lt3J/J

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: DctSlt-lt3J/Dct+
Genetic Background: B6(Cg)-DctSlt-lt3J/J

 MP:0004025 polyploidy "more than two chromosome sets are present" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: DctSlt-lt3J/Dct+
Genetic Background: B6(Cg)-DctSlt-lt3J/J

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Pcdhgtm2Xzw/Pcdhgtm2Xzw,Robo2tm1Rilm/Robo2tm1Rilm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: DctSlt-lt3J/Dct+
Genetic Background: B6(Cg)-DctSlt-lt3J/J

 MP:0011209 absent extraembryonic coelom "absence of the fluid-filled spaces formed within the mass of extraembryonic mesoderm that later fuse to become a large extraembryonic cavity" [ISBN:0-12-402035-6, ISBN10:1405118660]
Show

Allelic Composition: DctSlt-lt3J/Dct+
Genetic Background: B6(Cg)-DctSlt-lt3J/J

 MP:0012114 absent inner cell mass proliferation 
Show

Allelic Composition: DctSlt-lt3J/Dct+
Genetic Background: B6(Cg)-DctSlt-lt3J/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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