ENSMUSG00000042289


Mus musculus

Features
Gene ID: ENSMUSG00000042289
  
Biological name :Hsd3b7
  
Synonyms : Hsd3b7 / hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 / Q9EQC1
  
Possible biological names infered from orthology : Q9H2F3
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F3
Gene start: 127800604
Gene end: 127803802
  
Corresponding Affymetrix probe sets: 10557782 (MoGene1.0st)   1416968_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000036245
Ensembl peptide - ENSMUSP00000146308
Ensembl peptide - ENSMUSP00000145804
Ensembl peptide - ENSMUSP00000145613
Ensembl peptide - ENSMUSP00000121246
Ensembl peptide - ENSMUSP00000114536
Ensembl peptide - ENSMUSP00000101879
Ensembl peptide - ENSMUSP00000101878
NCBI entrez gene - 101502     See in Manteia.
MGI - MGI:2141879
RefSeq - XM_017321906
RefSeq - NM_001040684
RefSeq - NM_133943
RefSeq - XM_017321905
RefSeq Peptide - NP_598704
RefSeq Peptide - NP_001035774
swissprot - D3Z3X1
swissprot - Q9EQC1
swissprot - D3Z3X2
swissprot - D3YVB8
swissprot - D3YU71
swissprot - A0A0U1RP28
swissprot - A0A0U1RQA2
swissprot - A0A0U1RNL4
Ensembl - ENSMUSG00000042289
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hsd3b7ENSDARG00000036966Danio rerio
 ENSGALG00000045366Gallus gallus
 HSD3B7ENSG00000099377Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hsd3b1 / P24815 / hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 / P26439* / HSD3B2* / P14060* / hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid del...ENSMUSG0000002787139
Q61694 / Hsd3b5 / hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 / HSD3B1* / P14060* / P26439* / HSD3B2* / hydroxy-delta-5-steroid dehydrogenase, 3 beta- and s...ENSMUSG0000003809238
Q61767 / Hsd3b4 / hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 4 / HSD3B1* / P14060* / P26439* / HSD3B2* / hydroxy-delta-5-steroid dehydrogenase, 3 beta- and s...ENSMUSG0000009514338
Q61767 / Gm10681 / predicted gene 10681 / HSD3B1* / P26439* / P14060* / HSD3B2* / hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2* / hydroxy-delta-5-steroid deh...ENSMUSG0000009538838
O35469 / Hsd3b6 / hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6 / P26439* / HSD3B1* / HSD3B2* / P14060* / hydroxy-delta-5-steroid dehydrogenase, 3 beta- and s...ENSMUSG0000002786937
P26150 / Hsd3b3 / hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3 / P26439* / HSD3B1* / HSD3B2* / P14060* / hydroxy-delta-5-steroid dehydrogenase, 3 beta- and s...ENSMUSG0000006241037
P26149 / Hsd3b2 / hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 / P14060* / HSD3B1* / P26439* / hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid del...ENSMUSG0000006373036
Gm5737 / short chain dehydrogenase/reductase family 42E, member 2 / A6NKP2* / SDR42E2*ENSMUSG0000010939228
Nsdhl / Q9R1J0 / Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating / Q15738* / NAD(P) dependent steroid dehydrogenase-like*ENSMUSG0000003134928
Q9D665 / Sdr42e1 / short chain dehydrogenase/reductase family 42E, member 1 / Q8WUS8*ENSMUSG0000003430826
Gm4450 / HSD3B2* / P26439* / HSD3B1* / P14060* / hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1* / hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid d...ENSMUSG0000009081722


Protein motifs (from Interpro)
Interpro ID Name
 IPR002225  3-beta hydroxysteroid dehydrogenase/isomerase
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006694 steroid biosynthetic process IEA
 biological_processGO:0035754 B cell chemotaxis IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005811 lipid droplet IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
 molecular_functionGO:0047016 cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity IMP


Pathways (from Reactome)
Pathway description
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 24-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001192 scaly skin "skin covered with shedding scales or flakes" [J:65146]
Show

Allelic Composition: Fbxl3Gt(FHCRC-GT-S13-12G1)Sor/Fbxl3Ovtm
Genetic Background: involves: BTBR/J * C3H/HeJ * C57BL/6J

 MP:0001197 oily skin 
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Allelic Composition: Fbxl3Gt(FHCRC-GT-S13-12G1)Sor/Fbxl3Ovtm
Genetic Background: involves: BTBR/J * C3H/HeJ * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fbxl3Gt(FHCRC-GT-S13-12G1)Sor/Fbxl3Ovtm
Genetic Background: involves: BTBR/J * C3H/HeJ * C57BL/6J

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fbxl3Gt(FHCRC-GT-S13-12G1)Sor/Fbxl3Ovtm
Genetic Background: involves: BTBR/J * C3H/HeJ * C57BL/6J

 MP:0002647 decreased cholesterol absorption "reduced ability of the body to take in these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fbxl3Gt(FHCRC-GT-S13-12G1)Sor/Fbxl3Ovtm
Genetic Background: involves: BTBR/J * C3H/HeJ * C57BL/6J

 MP:0005278 abnormal cholesterol homeostasis "anomaly in the state of equilibrium in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:71350]
Show

Allelic Composition: Fbxl3Gt(FHCRC-GT-S13-12G1)Sor/Fbxl3Ovtm
Genetic Background: involves: BTBR/J * C3H/HeJ * C57BL/6J

 MP:0005281 increased fatty acid level "higher than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fbxl3Gt(FHCRC-GT-S13-12G1)Sor/Fbxl3Ovtm
Genetic Background: involves: BTBR/J * C3H/HeJ * C57BL/6J

 MP:0005365 abnormal bile salt homeostasis "anomalous regulation of the steroid salts derived from cholesterol in the liver and which play an important role in the digestion and absorption of fats" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86154]
Show

Allelic Composition: Fbxl3Gt(FHCRC-GT-S13-12G1)Sor/Fbxl3Ovtm
Genetic Background: involves: BTBR/J * C3H/HeJ * C57BL/6J

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fbxl3Gt(FHCRC-GT-S13-12G1)Sor/Fbxl3Ovtm
Genetic Background: involves: BTBR/J * C3H/HeJ * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Fbxl3Gt(FHCRC-GT-S13-12G1)Sor/Fbxl3Ovtm
Genetic Background: involves: BTBR/J * C3H/HeJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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