ENSMUSG00000042345


Mus musculus

Features
Gene ID: ENSMUSG00000042345
  
Biological name :Ubash3a
  
Synonyms : Q3V3E1 / Ubash3a / ubiquitin associated and SH3 domain containing, A
  
Possible biological names infered from orthology : P57075
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: A3.3
Gene start: 31207873
Gene end: 31242202
  
Corresponding Affymetrix probe sets: 10443749 (MoGene1.0st)   1431698_at (Mouse Genome 430 2.0 Array)   1456065_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134557
Ensembl peptide - ENSMUSP00000045890
Ensembl peptide - ENSMUSP00000119279
NCBI entrez gene - 328795     See in Manteia.
MGI - MGI:1926074
RefSeq - XM_006524434
RefSeq - XM_011246500
RefSeq - NM_177823
RefSeq Peptide - NP_808491
swissprot - Q3V3E1
swissprot - G3UZM7
swissprot - D6RCF9
Ensembl - ENSMUSG00000042345
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P57075ENSG00000160185Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8BGG7 / Ubash3b / ubiquitin associated and SH3 domain containing, B / Q8TF42*ENSMUSG0000003202046


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR009060  UBA-like superfamily
 IPR009097  Cyclic phosphodiesterase
 IPR013078  Histidine phosphatase superfamily, clade-1
 IPR015940  Ubiquitin-associated domain
 IPR029033  Histidine phosphatase superfamily
 IPR035634  UBASH3A, SH3 domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001817 regulation of cytokine production IGI
 biological_processGO:0050860 negative regulation of T cell receptor signaling pathway IGI
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bdnftm3Jae/Bdnftm3Jae,Tg(Eno2tTA)5030Nes/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129/Sv * C57BL/6 * ICR * SJL

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Bdnftm3Jae/Bdnftm3Jae,Tg(Eno2tTA)5030Nes/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129/Sv * C57BL/6 * ICR * SJL

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bdnftm3Jae/Bdnftm3Jae,Tg(Eno2tTA)5030Nes/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129/Sv * C57BL/6 * ICR * SJL

Allelic Composition: Cblbtm1Hua/Cblbtm1Hua,Ubash3btm1Jni/Ubash3btm1Jni,Ubash3atm1Jni/Ubash3atm1Jni
Genetic Background: Not Specified

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bdnftm3Jae/Bdnftm3Jae,Tg(Eno2tTA)5030Nes/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129/Sv * C57BL/6 * ICR * SJL

Allelic Composition: Cblbtm1Hua/Cblbtm1Hua,Ubash3btm1Jni/Ubash3btm1Jni,Ubash3atm1Jni/Ubash3atm1Jni
Genetic Background: Not Specified

 MP:0008210 increased mature B cell number "greater number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Bdnftm3Jae/Bdnftm3Jae,Tg(Eno2tTA)5030Nes/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129/Sv * C57BL/6 * ICR * SJL

 MP:0009338 increased splenocyte number "increase in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bdnftm3Jae/Bdnftm3Jae,Tg(Eno2tTA)5030Nes/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129/Sv * C57BL/6 * ICR * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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