ENSMUSG00000032020


Mus musculus

Features
Gene ID: ENSMUSG00000032020
  
Biological name :Ubash3b
  
Synonyms : Q8BGG7 / Ubash3b / ubiquitin associated and SH3 domain containing, B
  
Possible biological names infered from orthology : Q8TF42
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A5.1
Gene start: 41011098
Gene end: 41161697
  
Corresponding Affymetrix probe sets: 10592515 (MoGene1.0st)   1429475_at (Mouse Genome 430 2.0 Array)   1435703_at (Mouse Genome 430 2.0 Array)   1436805_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000043865
Ensembl peptide - ENSMUSP00000114176
Ensembl peptide - ENSMUSP00000116038
Ensembl peptide - ENSMUSP00000134923
NCBI entrez gene - 72828     See in Manteia.
MGI - MGI:1920078
RefSeq - XM_017313612
RefSeq - NM_176860
RefSeq - XM_006510632
RefSeq - XM_006510634
RefSeq - XM_006510636
RefSeq - XM_006510637
RefSeq Peptide - NP_001344341
RefSeq Peptide - NP_789830
swissprot - H3BJB9
swissprot - D3YVT5
swissprot - Q8BGG7
Ensembl - ENSMUSG00000032020
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ubash3baENSDARG00000061243Danio rerio
 ubash3bbENSDARG00000077399Danio rerio
 UBASH3BENSGALG00000006567Gallus gallus
 Q8TF42ENSG00000154127Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q3V3E1 / Ubash3a / ubiquitin associated and SH3 domain containing, A / P57075*ENSMUSG0000004234545


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR009060  UBA-like superfamily
 IPR009097  Cyclic phosphodiesterase
 IPR013078  Histidine phosphatase superfamily, clade-1
 IPR015940  Ubiquitin-associated domain
 IPR029033  Histidine phosphatase superfamily
 IPR035632  UBASH3B, SH3 domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006469 negative regulation of protein kinase activity IMP
 biological_processGO:0009968 negative regulation of signal transduction IMP
 biological_processGO:0030168 platelet activation IMP
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IMP
 biological_processGO:0038063 collagen-activated tyrosine kinase receptor signaling pathway IMP
 biological_processGO:0038065 collagen-activated signaling pathway IMP
 biological_processGO:0043393 regulation of protein binding IMP
 biological_processGO:0045670 regulation of osteoclast differentiation IMP
 biological_processGO:0045671 negative regulation of osteoclast differentiation IMP
 biological_processGO:0045779 negative regulation of bone resorption IMP
 biological_processGO:0051279 regulation of release of sequestered calcium ion into cytosol IMP
 biological_processGO:0070527 platelet aggregation IMP
 biological_processGO:0090331 negative regulation of platelet aggregation IMP
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IMP
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0051219 phosphoprotein binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ikzf1plstc/Ikzf1+
Genetic Background: C57BL/6JSfdAnu-Ikzf1plstc

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bdnftm3Jae/Bdnftm3Jae,Tg(Eno2tTA)5030Nes/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129/Sv * C57BL/6 * ICR * SJL

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bdnftm3Jae/Bdnftm3Jae,Tg(Eno2tTA)5030Nes/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129/Sv * C57BL/6 * ICR * SJL

Allelic Composition: Cblbtm1Hua/Cblbtm1Hua,Ubash3btm1Jni/Ubash3btm1Jni,Ubash3atm1Jni/Ubash3atm1Jni
Genetic Background: Not Specified

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bdnftm3Jae/Bdnftm3Jae,Tg(Eno2tTA)5030Nes/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129/Sv * C57BL/6 * ICR * SJL

Allelic Composition: Cblbtm1Hua/Cblbtm1Hua,Ubash3btm1Jni/Ubash3btm1Jni,Ubash3atm1Jni/Ubash3atm1Jni
Genetic Background: Not Specified

 MP:0008210 increased mature B cell number "greater number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
Show

Allelic Composition: Bdnftm3Jae/Bdnftm3Jae,Tg(Eno2tTA)5030Nes/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129/Sv * C57BL/6 * ICR * SJL

 MP:0009338 increased splenocyte number "increase in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bdnftm3Jae/Bdnftm3Jae,Tg(Eno2tTA)5030Nes/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129/Sv * C57BL/6 * ICR * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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