ENSMUSG00000042508


Mus musculus

Features
Gene ID: ENSMUSG00000042508
  
Biological name :Dmtf1
  
Synonyms : Cyclin-D-binding Myb-like transcription factor 1 / Dmtf1 / Q8CE22
  
Possible biological names infered from orthology : Q9Y222
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: A1
Gene start: 9118801
Gene end: 9161776
  
Corresponding Affymetrix probe sets: 10528120 (MoGene1.0st)   1422636_at (Mouse Genome 430 2.0 Array)   1439376_x_at (Mouse Genome 430 2.0 Array)   1456697_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000071815
Ensembl peptide - ENSMUSP00000092627
Ensembl peptide - ENSMUSP00000139339
Ensembl peptide - ENSMUSP00000139361
Ensembl peptide - ENSMUSP00000138816
Ensembl peptide - ENSMUSP00000138861
Ensembl peptide - ENSMUSP00000138935
Ensembl peptide - ENSMUSP00000138997
Ensembl peptide - ENSMUSP00000139042
Ensembl peptide - ENSMUSP00000139164
Ensembl peptide - ENSMUSP00000139191
Ensembl peptide - ENSMUSP00000139231
Ensembl peptide - ENSMUSP00000139281
NCBI entrez gene - 23857     See in Manteia.
MGI - MGI:1344415
RefSeq - XM_017320878
RefSeq - NM_001110327
RefSeq - NM_011806
RefSeq - XM_006503572
RefSeq - XM_006503574
RefSeq - XM_011240668
RefSeq - XM_011240669
RefSeq Peptide - NP_035936
RefSeq Peptide - NP_001103797
swissprot - V9GXK4
swissprot - V9GXV6
swissprot - V9GXX1
swissprot - Q8CE22
swissprot - V9GWT2
swissprot - V9GX14
swissprot - V9GWW5
swissprot - V9GX59
Ensembl - ENSMUSG00000042508
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dmtf1ENSDARG00000025824Danio rerio
 DMTF1ENSGALG00000030844Gallus gallus
 DMTF1ENSG00000135164Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
4932411N23Rik / RIKEN cDNA 4932411N23 gene / DMTF1* / Q9Y222* / cyclin D binding myb like transcription factor 1*ENSMUSG0000005867038
Ttf1 / Q62187 / transcription termination factor, RNA polymerase I / Q15361* / transcription termination factor 1*ENSMUSG0000002680314


Protein motifs (from Interpro)
Interpro ID Name
 IPR001005  SANT/Myb domain
 IPR009057  Homeobox-like domain superfamily
 IPR017877  Myb-like domain
 IPR017930  Myb domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005829 cytosol ISO
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting IBA
 molecular_functionGO:0003677 DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000516 abnormal urinary system morphology "structural or developmental anomaly of any of the organs involved in the production or excretion of urine " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rettm13.1Jmi/Rettm13.1Jmi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0000539 distended urinary bladder "stretched musculomembranous bag for holding urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rettm13.1Jmi/Rettm13.1Jmi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Rettm13.1Jmi/Rettm13.1Jmi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0000858 altered metastatic potential 
Show

Allelic Composition: Dmtf1tm1Cjs/Dmtf1+,Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Dmtf1tm1Cjs/Dmtf1tm1Cjs,Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Dmtf1tm1Cjs/Dmtf1+,Krastm3Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001145 abnormal male reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that produces spermatozoa" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rettm13.1Jmi/Rettm13.1Jmi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rettm13.1Jmi/Rettm13.1Jmi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rettm13.1Jmi/Rettm13.1Jmi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Rettm13.1Jmi/Rettm13.1Jmi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Dmtf1tm1Cjs/Dmtf1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002021 increased incidence of induced tumors "higher than normal frequency of tumor incidence induced by a carcinogen or mutagen" [J:44427]
Show

Allelic Composition: Rettm13.1Jmi/Rettm13.1Jmi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Dmtf1tm1Cjs/Dmtf1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Dmtf1tm1Cjs/Dmtf1+,Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Dmtf1tm1Cjs/Dmtf1tm1Cjs,Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Dmtf1tm1Cjs/Dmtf1+,Krastm3Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Dmtf1tm1Cjs/Dmtf1tm1Cjs,Krastm3Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
Show

Allelic Composition: Dmtf1tm1Cjs/Dmtf1+,Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Dmtf1tm1Cjs/Dmtf1tm1Cjs,Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Dmtf1tm1Cjs/Dmtf1+,Krastm3Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Dmtf1tm1Cjs/Dmtf1tm1Cjs,Krastm3Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002048 lung adenoma "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
Show

Allelic Composition: Dmtf1tm1Cjs/Dmtf1+,Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Dmtf1tm1Cjs/Dmtf1tm1Cjs,Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Dmtf1tm1Cjs/Dmtf1+,Krastm3Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Dmtf1tm1Cjs/Dmtf1tm1Cjs,Krastm3Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002051 skin papilloma "a circumscribed, benign epithelial tumor projecting from the surrounding surface" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dmtf1tm1Cjs/Dmtf1+,Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Dmtf1tm1Cjs/Dmtf1tm1Cjs,Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Dmtf1tm1Cjs/Dmtf1+,Krastm3Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Dmtf1tm1Cjs/Dmtf1tm1Cjs,Krastm3Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rettm13.1Jmi/Rettm13.1Jmi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprdb-9J/Leprdb-9J
Genetic Background: involves: C57BL/6 * CBA * SWR

Allelic Composition: Dmtf1tm1Cjs/Dmtf1tm1Cjs,Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Dmtf1tm1Cjs/Dmtf1+,Krastm3Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Dmtf1tm1Cjs/Dmtf1tm1Cjs,Krastm3Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rettm13.1Jmi/Rettm13.1Jmi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0003789 osteosarcoma "malignant neoplasm derived from bone" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dmtf1tm1Cjs/Dmtf1+,Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008000 ovary tumor "presence of abnormal rapidly proliferating cells in the ovary, usually in the form of a distinct mass" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dmtf1tm1Cjs/Dmtf1tm1Cjs,Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008014 lung tumor "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dmtf1tm1Cjs/Dmtf1+,Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Dmtf1tm1Cjs/Dmtf1tm1Cjs,Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Dmtf1tm1Cjs/Dmtf1+,Krastm3Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Dmtf1tm1Cjs/Dmtf1tm1Cjs,Krastm3Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rettm13.1Jmi/Rettm13.1Jmi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rettm13.1Jmi/Rettm13.1Jmi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0010308 decreased tumor latency "earlier onset of tumor occurrence than expected" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dmtf1tm1Cjs/Dmtf1+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Dmtf1tm1Cjs/Dmtf1+,Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Dmtf1tm1Cjs/Dmtf1tm1Cjs,Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Dmtf1tm1Cjs/Dmtf1+,Krastm3Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Dmtf1tm1Cjs/Dmtf1tm1Cjs,Krastm3Tyj/Kras+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010314 increased neurofibroma incidence "greater than the expected number of benign, encapsulated nerve sheath tumors composed of Schwann cells, in a specific population in a given time period; proliferation is disordered and includes portions of nerve fibers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dmtf1tm1Cjs/Dmtf1+,Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010315 increased cholangiocarcinoma incidence "greater than the expected number of malignant adenocarcimomas arising in the intrahepatic bile duct epithelium, in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dmtf1tm1Cjs/Dmtf1+,Krastm2Tyj/Kras+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Rettm13.1Jmi/Rettm13.1Jmi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0013320 dilated seminal vesicles "an expansion in the lumen volume of either of the paired sac-like glandular structures situated posterolateral to the urinary bladder in the male and functioning as part of the reproductive system, as by stretching or distention" [MGI:Anna]
Show

Allelic Composition: Rettm13.1Jmi/Rettm13.1Jmi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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