ENSMUSG00000043410


Mus musculus

Features
Gene ID: ENSMUSG00000043410
  
Biological name :Hfm1
  
Synonyms : D3Z4R1 / Hfm1 / Probable ATP-dependent DNA helicase HFM1
  
Possible biological names infered from orthology : A2PYH4 / HFM1, ATP dependent DNA helicase homolog
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: E5
Gene start: 106840192
Gene end: 106926321
  
Corresponding Affymetrix probe sets: 10532052 (MoGene1.0st)   10532072 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000122169
Ensembl peptide - ENSMUSP00000118674
Ensembl peptide - ENSMUSP00000142727
Ensembl peptide - ENSMUSP00000120112
Ensembl peptide - ENSMUSP00000108310
Ensembl peptide - ENSMUSP00000112590
NCBI entrez gene - 330149     See in Manteia.
MGI - MGI:3036246
RefSeq - XM_006535016
RefSeq - XM_011249484
RefSeq - XM_011249488
RefSeq - XM_011249487
RefSeq - XM_011249486
RefSeq - NM_001252516
RefSeq - NM_177873
RefSeq - XM_017320932
RefSeq - XM_011249485
RefSeq - XM_006535015
RefSeq Peptide - NP_808541
RefSeq Peptide - NP_001239445
swissprot - D6RJK3
swissprot - A0A0G2JED3
swissprot - F7C082
swissprot - F6XQ35
swissprot - D3Z4R1
Ensembl - ENSMUSG00000043410
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hfm1ENSDARG00000104288Danio rerio
 HFM1ENSGALG00000006091Gallus gallus
 HFM1ENSG00000162669Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001650  Helicase, C-terminal
 IPR004179  Sec63 domain
 IPR011545  DEAD/DEAH box helicase domain
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000712 resolution of meiotic recombination intermediates IMP
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0010501 RNA secondary structure unwinding IBA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0048477 oogenesis IEA
 biological_processGO:0051321 meiotic cell cycle IEA
 cellular_componentGO:0005730 nucleolus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0004004 ATP-dependent RNA helicase activity IBA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001126 abnormal ovary morphology "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde/Gt(ROSA)26Sor+,Trpv1tm1Jul/Trpv1tm1Jul,Tg(Mrgpra3-GFP/cre)#Xzd/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde/Gt(ROSA)26Sor+,Trpv1tm1Jul/Trpv1tm1Jul,Tg(Mrgpra3-GFP/cre)#Xzd/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde/Gt(ROSA)26Sor+,Trpv1tm1Jul/Trpv1tm1Jul,Tg(Mrgpra3-GFP/cre)#Xzd/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde/Gt(ROSA)26Sor+,Trpv1tm1Jul/Trpv1tm1Jul,Tg(Mrgpra3-GFP/cre)#Xzd/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde/Gt(ROSA)26Sor+,Trpv1tm1Jul/Trpv1tm1Jul,Tg(Mrgpra3-GFP/cre)#Xzd/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde/Gt(ROSA)26Sor+,Trpv1tm1Jul/Trpv1tm1Jul,Tg(Mrgpra3-GFP/cre)#Xzd/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde/Gt(ROSA)26Sor+,Trpv1tm1Jul/Trpv1tm1Jul,Tg(Mrgpra3-GFP/cre)#Xzd/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde/Gt(ROSA)26Sor+,Trpv1tm1Jul/Trpv1tm1Jul,Tg(Mrgpra3-GFP/cre)#Xzd/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0001929 abnormal gametogenesis "defective formation or differentiation of germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:42324]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde/Gt(ROSA)26Sor+,Trpv1tm1Jul/Trpv1tm1Jul,Tg(Mrgpra3-GFP/cre)#Xzd/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0001930 abnormal meiosis "malfunction in the process of nuclear division that results in gametes with one half the normal number of the original cell" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde/Gt(ROSA)26Sor+,Trpv1tm1Jul/Trpv1tm1Jul,Tg(Mrgpra3-GFP/cre)#Xzd/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0001931 abnormal oogenesis "atypical formation or failure to form the female germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde/Gt(ROSA)26Sor+,Trpv1tm1Jul/Trpv1tm1Jul,Tg(Mrgpra3-GFP/cre)#Xzd/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0001940 testicular hypoplasia "decreased cell number in the testicles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde/Gt(ROSA)26Sor+,Trpv1tm1Jul/Trpv1tm1Jul,Tg(Mrgpra3-GFP/cre)#Xzd/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0002160 abnormal reproductive system morphology "structural or developmental anomaly of any of the tissues involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde/Gt(ROSA)26Sor+,Trpv1tm1Jul/Trpv1tm1Jul,Tg(Mrgpra3-GFP/cre)#Xzd/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde/Gt(ROSA)26Sor+,Trpv1tm1Jul/Trpv1tm1Jul,Tg(Mrgpra3-GFP/cre)#Xzd/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0002680 decreased number of corpora lutea "fewer than normal numbers of yellow endocrine body formed in the ovary after follicle rupture in a given oestrus cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde/Gt(ROSA)26Sor+,Trpv1tm1Jul/Trpv1tm1Jul,Tg(Mrgpra3-GFP/cre)#Xzd/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde/Gt(ROSA)26Sor+,Trpv1tm1Jul/Trpv1tm1Jul,Tg(Mrgpra3-GFP/cre)#Xzd/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0008871 abnormal ovarian follicle number "abnormal numbers of spheroid cell aggregations in the ovary" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde/Gt(ROSA)26Sor+,Trpv1tm1Jul/Trpv1tm1Jul,Tg(Mrgpra3-GFP/cre)#Xzd/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0008966 abnormal chiasmata formation "atypical contact between nonsister chromatids of homologous chromosomes during meiosis I, precluding formation of the expected number of cross-shaped configurations representing recombination events" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde/Gt(ROSA)26Sor+,Trpv1tm1Jul/Trpv1tm1Jul,Tg(Mrgpra3-GFP/cre)#Xzd/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0009451 abnormal chromosome pairing during meiosis "an anomaly in the highly specific side-by-side association of homologous chromosomes during first prophase of meiosis" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde/Gt(ROSA)26Sor+,Trpv1tm1Jul/Trpv1tm1Jul,Tg(Mrgpra3-GFP/cre)#Xzd/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0009452 abnormal synaptonemal complex "an anomaly in the formation of the proteinaceous structure involved in the pairing of homologous chromosomes during first prophase of meiosis" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde/Gt(ROSA)26Sor+,Trpv1tm1Jul/Trpv1tm1Jul,Tg(Mrgpra3-GFP/cre)#Xzd/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0009564 abnormal meiotic configurations "uncharacteristic chromosome arrangement produced by anomalous chromosome pairing and chiasma formation from prophase to metaphase of meiosis I due to abnormal chromosome structure and necessary to produce functional gametes" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde/Gt(ROSA)26Sor+,Trpv1tm1Jul/Trpv1tm1Jul,Tg(Mrgpra3-GFP/cre)#Xzd/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0011751 abnormal X-Y chromosome synapsis during male meiosis "an anomaly in the process in which the side by side pairing and physical juxtaposition of X and Y chromosomes is created at the metaphase plate, usually resulting in incorrect sex chromosome disjunction" [MGI:llw2]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde/Gt(ROSA)26Sor+,Trpv1tm1Jul/Trpv1tm1Jul,Tg(Mrgpra3-GFP/cre)#Xzd/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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