ENSMUSG00000043456


Mus musculus

Features
Gene ID: ENSMUSG00000043456
  
Biological name :Zfp536
  
Synonyms : Q8K083 / Zfp536 / zinc finger protein 536
  
Possible biological names infered from orthology : O15090 / ZNF536
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B3
Gene start: 37472135
Gene end: 37773641
  
Corresponding Affymetrix probe sets: 10562532 (MoGene1.0st)   1456093_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135681
Ensembl peptide - ENSMUSP00000058468
Ensembl peptide - ENSMUSP00000134778
Ensembl peptide - ENSMUSP00000135068
Ensembl peptide - ENSMUSP00000135218
Ensembl peptide - ENSMUSP00000135234
Ensembl peptide - ENSMUSP00000135454
NCBI entrez gene - 243937     See in Manteia.
MGI - MGI:1926102
RefSeq - XM_017322250
RefSeq - XM_017322245
RefSeq - XM_017322246
RefSeq - XM_017322247
RefSeq - XM_017322248
RefSeq - XM_017322249
RefSeq - NM_172385
RefSeq - XM_011250580
RefSeq - XM_017322240
RefSeq - XM_017322241
RefSeq - XM_017322242
RefSeq - XM_017322243
RefSeq - XM_017322244
RefSeq Peptide - NP_759017
swissprot - H3BKM9
swissprot - H3BK19
swissprot - Q3TR09
swissprot - Q8K083
Ensembl - ENSMUSG00000043456
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 znf536ENSDARG00000103648Danio rerio
 ZNF536ENSGALG00000035602Gallus gallus
 O15090ENSG00000198597Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6IQX8 / Zfp219 / zinc finger protein 219 / Q9P2Y4* / ZNF219*ENSMUSG0000004929522
Q7TSH3 / Zfp516 / zinc finger protein 516 / Q92618* / ZNF516*ENSMUSG0000005888121
Zfp217 / zinc finger protein 217 / O75362* / ZNF217*ENSMUSG0000005205619


Protein motifs (from Interpro)
Interpro ID Name
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IBA
 biological_processGO:0045665 negative regulation of neuron differentiation IDA
 biological_processGO:0048387 negative regulation of retinoic acid receptor signaling pathway IDA
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IBA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IBA
 molecular_functionGO:0044323 retinoic acid-responsive element binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Nsd3tm1b(EUCOMM)Hmgu/Nsd3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nsd3tm1b(EUCOMM)Hmgu/H

 MP:0005388 respiratory system phenotype 
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Allelic Composition: Nsd3tm1b(EUCOMM)Hmgu/Nsd3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nsd3tm1b(EUCOMM)Hmgu/H

 MP:0005564 increased hemoglobin content "increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Trip13tm1.1(KOMP)Vlcg/Trip13tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Trip13tm1.1(KOMP)Vlcg/Ucd

 MP:0005641 increased mean corpuscular hemoglobin concentration "greater than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
Show

Allelic Composition: Trip13tm1.1(KOMP)Vlcg/Trip13tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Trip13tm1.1(KOMP)Vlcg/Ucd

 MP:0009141 increased prepulse inhibition "increase in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trip13tm1.1(KOMP)Vlcg/Trip13tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Trip13tm1.1(KOMP)Vlcg/Ucd

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Nsd3tm1b(EUCOMM)Hmgu/Nsd3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nsd3tm1b(EUCOMM)Hmgu/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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