ENSMUSG00000043866


Mus musculus

Features
Gene ID: ENSMUSG00000043866
  
Biological name :Taf10
  
Synonyms : Q8K0H5 / Taf10 / Transcription initiation factor TFIID subunit 10
  
Possible biological names infered from orthology : Q12962 / TATA-box binding protein associated factor 10
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: E3
Gene start: 105739393
Gene end: 105744361
  
Corresponding Affymetrix probe sets: 10365288 (MoGene1.0st)   10566525 (MoGene1.0st)   1448784_at (Mouse Genome 430 2.0 Array)   1455625_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118105
NCBI entrez gene - 24075     See in Manteia.
MGI - MGI:1346320
RefSeq - NM_020024
RefSeq - XM_006507814
RefSeq Peptide - NP_064408
swissprot - Q8K0H5
Ensembl - ENSMUSG00000043866
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 taf10ENSDARG00000068641Danio rerio
 TAF10ENSGALG00000046371Gallus gallus
 TAF10ENSG00000166337Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003923  Transcription initiation factor TFIID, 23-30kDa subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IMP
 biological_processGO:0001889 liver development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006352 DNA-templated transcription, initiation ISO
 biological_processGO:0006355 regulation of transcription, DNA-templated TAS
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter IEA
 biological_processGO:0006915 apoptotic process IMP
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0016578 histone deubiquitination IEA
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0043966 histone H3 acetylation IEA
 biological_processGO:0051101 regulation of DNA binding IMP
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0070365 hepatocyte differentiation IMP
 cellular_componentGO:0000125 PCAF complex IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005669 transcription factor TFIID complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0030914 STAGA complex IEA
 cellular_componentGO:0033276 transcription factor TFTC complex IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0004402 histone acetyltransferase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0030331 estrogen receptor binding IEA
 molecular_functionGO:0070063 RNA polymerase binding IEA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases
RNA Polymerase II Pre-transcription Events
Regulation of TP53 Activity through Phosphorylation
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Initiation And Promoter Clearance


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hsd11b1tm1Yko/Hsd11b1tm1Yko
Genetic Background: B6.129P2(Cg)-Hsd11b1tm1Yko

 MP:0001196 shiny skin "skin with a glossy or glistening appearance" [J:56641]
Show

Allelic Composition: Hsd11b1tm1Yko/Hsd11b1tm1Yko
Genetic Background: B6.129P2(Cg)-Hsd11b1tm1Yko

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hsd11b1tm1Yko/Hsd11b1tm1Yko
Genetic Background: B6.129P2(Cg)-Hsd11b1tm1Yko

 MP:0001240 abnormal cornified layer morphology "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hsd11b1tm1Yko/Hsd11b1tm1Yko
Genetic Background: B6.129P2(Cg)-Hsd11b1tm1Yko

 MP:0001241 absent cornified layer "missing the outer layer of the epidermis, composed of several layers of keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hsd11b1tm1Yko/Hsd11b1tm1Yko
Genetic Background: B6.129P2(Cg)-Hsd11b1tm1Yko

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
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Allelic Composition: Hsd11b1tm1Yko/Hsd11b1tm1Yko
Genetic Background: B6.129P2(Cg)-Hsd11b1tm1Yko

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ubr5tm1Ckww/Ubr5tm1Ckww,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0002656 abnormal keratinocyte differentiation "developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hsd11b1tm1Yko/Hsd11b1tm1Yko
Genetic Background: B6.129P2(Cg)-Hsd11b1tm1Yko

 MP:0002718 abnormal inner cell mass "malformed or absent cells of the blastocyst that develop into the body of the embryo" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ubr5tm1Ckww/Ubr5tm1Ckww,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
Show

Allelic Composition: Hsd11b1tm1Yko/Hsd11b1tm1Yko
Genetic Background: B6.129P2(Cg)-Hsd11b1tm1Yko

 MP:0003853 dry skin "skin characterized by the lack of natural or normal moisture" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hsd11b1tm1Yko/Hsd11b1tm1Yko
Genetic Background: B6.129P2(Cg)-Hsd11b1tm1Yko

 MP:0003886 abnormal embryonic epiblast morphology "anomaly in the development/organization of the tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ubr5tm1Ckww/Ubr5tm1Ckww,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ubr5tm1Ckww/Ubr5tm1Ckww,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0005031 abnormal trophoblast "malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ubr5tm1Ckww/Ubr5tm1Ckww,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0009608 abnormal lamellar body morphology "any structural anomaly of a membrane-bounded organelle, specialized for the storage and secretion various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae" [GO:0042599]
Show

Allelic Composition: Hsd11b1tm1Yko/Hsd11b1tm1Yko
Genetic Background: B6.129P2(Cg)-Hsd11b1tm1Yko

 MP:0010380 inner cell mass apoptosis "the cells of the blastocyst that develop into the body of the embryo are undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ubr5tm1Ckww/Ubr5tm1Ckww,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Hsd11b1tm1Yko/Hsd11b1tm1Yko
Genetic Background: B6.129P2(Cg)-Hsd11b1tm1Yko

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Ubr5tm1Ckww/Ubr5tm1Ckww,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0011184 absent embryonic epiblast "absence of the tissue derived from the inner cell mass that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper and to the extraembryonic mesoderm" [PMID:21123814]
Show

Allelic Composition: Ubr5tm1Ckww/Ubr5tm1Ckww,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0011189 small embryonic epiblast "reduced size of the tissue derived from the inner cell mass that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper and to the extraembryonic mesoderm" [PMID:21123814]
Show

Allelic Composition: Ubr5tm1Ckww/Ubr5tm1Ckww,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0012114 absent inner cell mass proliferation 
Show

Allelic Composition: Ubr5tm1Ckww/Ubr5tm1Ckww,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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