ENSMUSG00000043998


Mus musculus

Features
Gene ID: ENSMUSG00000043998
  
Biological name :Mgat2
  
Synonyms : Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase / Mgat2 / Q921V5
  
Possible biological names infered from orthology : mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase / Q10469
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: C2
Gene start: 69184157
Gene end: 69186770
  
Corresponding Affymetrix probe sets: 10396074 (MoGene1.0st)   1426350_at (Mouse Genome 430 2.0 Array)   1452037_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000057905
NCBI entrez gene - 217664     See in Manteia.
MGI - MGI:2384966
RefSeq - NM_146035
RefSeq Peptide - NP_666147
swissprot - Q921V5
Ensembl - ENSMUSG00000043998
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mgat2ENSDARG00000052408Danio rerio
 MGAT2ENSGALG00000031212Gallus gallus
 MGAT2ENSG00000168282Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007754  N-acetylglucosaminyltransferase II
 IPR029044  Nucleotide-diphospho-sugar transferases


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0006487 protein N-linked glycosylation IEA
 biological_processGO:0009312 oligosaccharide biosynthetic process IEA
 biological_processGO:0018279 protein N-linked glycosylation via asparagine IMP
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005795 Golgi stack IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0008455 alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity IMP
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0030246 carbohydrate binding IEA


Pathways (from Reactome)
Pathway description
Reactions specific to the complex N-glycan synthesis pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
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Allelic Composition: Dclre1ctm1.1Fwa/Dclre1ctm1.1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Dclre1ctm1.1Fwa/Dclre1ctm1.1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000069 kyphoscoliosis "kyphosis combined with scoliosis" [MGI:CML, J:66943]
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Allelic Composition: Dclre1ctm1.1Fwa/Dclre1ctm1.1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dclre1ctm1.1Fwa/Dclre1ctm1.1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000195 hypocalcemia "subnormal concentrations of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dclre1ctm1.1Fwa/Dclre1ctm1.1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000465 gastrointestinal hemorrhage "bleeding in the stomach and/or the intestines" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Dclre1ctm1.1Fwa/Dclre1ctm1.1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000493 rectal prolapse "downward movement and external appearance of the rectum through the anus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Dclre1ctm1.1Fwa/Dclre1ctm1.1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mgat2tm1.1Jxm/Mgat2tm1.1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mgat2tm1.1Jxm/Mgat2tm1.1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0000733 abnormal muscle development "anomalous differentiation of muscle tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dclre1ctm1.1Fwa/Dclre1ctm1.1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dclre1ctm1.1Fwa/Dclre1ctm1.1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000753 paralysis "loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dclre1ctm1.1Fwa/Dclre1ctm1.1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mgat2tm1.1Jxm/Mgat2tm1.1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Dclre1ctm1.1Fwa/Dclre1ctm1.1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Mgat2tm1.1Jxm/Mgat2tm1.1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
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Allelic Composition: Mgat2tm1.1Jxm/Mgat2tm1.1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dclre1ctm1.1Fwa/Dclre1ctm1.1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mgat2tm1.1Jxm/Mgat2tm1.1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Dclre1ctm1.1Fwa/Dclre1ctm1.1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001664 abnormal digestion "altered ability of the mechanical, chemical, and enzymatic processes of the body to convert ingested food into material suitable for assimiliation for synthesis of tissues or liberation of energy " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dclre1ctm1.1Fwa/Dclre1ctm1.1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Mgat2tm1.1Jxm/Mgat2tm1.1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Mgat2tm1.1Jxm/Mgat2tm1.1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mgat2tm1.1Jxm/Mgat2tm1.1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dclre1ctm1.1Fwa/Dclre1ctm1.1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dclre1ctm1.1Fwa/Dclre1ctm1.1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Dclre1ctm1.1Fwa/Dclre1ctm1.1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Mgat2tm1.1Jxm/Mgat2tm1.1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0002913 abnormal PNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the peripheral nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dclre1ctm1.1Fwa/Dclre1ctm1.1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Mgat2tm1.1Jxm/Mgat2tm1.1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0003743 abnormal facial morphology "anomalous structure or development of the face" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Dclre1ctm1.1Fwa/Dclre1ctm1.1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dclre1ctm1.1Fwa/Dclre1ctm1.1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mgat2tm1.1Jxm/Mgat2tm1.1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mgat2tm1.1Jxm/Mgat2tm1.1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0005161 hematuria "presence of blood in the urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:78193]
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Allelic Composition: Mgat2tm1.1Jxm/Mgat2tm1.1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0005567 decreased circulating total protein level "less than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
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Allelic Composition: Dclre1ctm1.1Fwa/Dclre1ctm1.1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Mgat2tm1.1Jxm/Mgat2tm1.1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Mgat2tm1.1Jxm/Mgat2tm1.1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Dclre1ctm1.1Fwa/Dclre1ctm1.1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Mgat2tm1.1Jxm/Mgat2tm1.1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Mgat2tm1.1Jxm/Mgat2tm1.1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Dclre1ctm1.1Fwa/Dclre1ctm1.1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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