ENSMUSG00000044857


Mus musculus

Features
Gene ID: ENSMUSG00000044857
  
Biological name :Lemd2
  
Synonyms : Lemd2 / LEM domain-containing protein 2 / Q6DVA0
  
Possible biological names infered from orthology : LEM domain containing 2 / Q8NC56
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A3.3
Gene start: 27189601
Gene end: 27204438
  
Corresponding Affymetrix probe sets: 10449327 (MoGene1.0st)   1424326_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000058221
NCBI entrez gene - 224640     See in Manteia.
MGI - MGI:2385045
RefSeq - NM_146075
RefSeq Peptide - NP_666187
swissprot - Q6DVA0
Ensembl - ENSMUSG00000044857
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LEMD2ENSGALG00000002870Gallus gallus
 LEMD2ENSG00000161904Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lemd3 / LEM domain containing 3 / Q9Y2U8*ENSMUSG0000004866130


Protein motifs (from Interpro)
Interpro ID Name
 IPR003887  LEM domain
 IPR011015  LEM/LEM-like domain superfamily
 IPR018996  Man1-Src1p-C-terminal domain
 IPR034994  LEM domain-containing protein 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006998 nuclear envelope organization IBA
 biological_processGO:0022008 neurogenesis IMP
 biological_processGO:0030514 negative regulation of BMP signaling pathway IBA
 biological_processGO:0035914 skeletal muscle cell differentiation IEA
 biological_processGO:0043409 negative regulation of MAPK cascade IMP
 biological_processGO:0051898 negative regulation of protein kinase B signaling IMP
 biological_processGO:0060914 heart formation IMP
 biological_processGO:0070197 meiotic attachment of telomere to nuclear envelope IBA
 biological_processGO:0071168 protein localization to chromatin IEA
 biological_processGO:1902531 regulation of intracellular signal transduction IEA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005637 nuclear inner membrane IEA
 cellular_componentGO:0005639 integral component of nuclear inner membrane IBA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 molecular_functionGO:0031490 chromatin DNA binding IBA


Pathways (from Reactome)
Pathway description
Depolymerisation of the Nuclear Lamina


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Juptm1Ruiz/Jup+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000841 abnormal hindbrain morphology "malformed caudal region of the brain; includes cerebellum, pons and medulla oblongata" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
Show

Allelic Composition: Juptm1Ruiz/Jup+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000897 abnormal midbrain "malformation or malfunction associated with the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions, including eye movement and coordination of auditory and visual reflexes" [J:23882, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Juptm1Ruiz/Jup+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Juptm1Ruiz/Jup+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
Show

Allelic Composition: Juptm1Ruiz/Jup+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Juptm1Ruiz/Jup+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Juptm1Ruiz/Jup+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Juptm1Ruiz/Jup+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
Show

Allelic Composition: Juptm1Ruiz/Jup+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Juptm1Ruiz/Jup+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Juptm1Ruiz/Jup+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003935 abnormal craniofacial development "anomaly in the process of forming the face and/or cranium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Juptm1Ruiz/Jup+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Juptm1Ruiz/Jup+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006069 abnormal retinal neuronal layer morphology "malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]
Show

Allelic Composition: Juptm1Ruiz/Jup+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006301 abnormal mesenchyme morphology "abnormality in the loosely packed, unspecialized cells that derive mostly from the mesoderm and contribute to connective tissue, bone, cartilage and circulatory and lymphatic systems." [J:120305, mnk:Michelle Knowlton_MGI Curator]
Show

Allelic Composition: Juptm1Ruiz/Jup+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006346 small branchial arch "reduced size of one or more of the branchial arches" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Juptm1Ruiz/Jup+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008932 abnormal embryonic tissue physiology "any functional anomaly in any of the tissues of the embryo proper" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Juptm1Ruiz/Jup+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010503 myocardial trabeculae hypoplasia "underdevelopment or reduced size of the supporting bundles of muscular fibers lining the walls of the heart, usually due to a reduced number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Juptm1Ruiz/Jup+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Juptm1Ruiz/Jup+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011827 impaired neuron differentiation "decreased production of or inability to produce the mature cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith]
Show

Allelic Composition: Juptm1Ruiz/Jup+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012701 increased embryonic neuroepithelium apoptosis "increase in the number of cells of the embryonic neuroepithelium undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Juptm1Ruiz/Jup+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012706 decreased embryonic neuroepithelial cell proliferation "decrease in the expansion rate of the cells of the embryonic neuroepithelium by cell division" [CL:0000710, MGI:anna]
Show

Allelic Composition: Juptm1Ruiz/Jup+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0013239 impaired skeletal muscle regeneration "reduced ability to repair skeletal muscle after injury or disease" [MGI:csmith]
Show

Allelic Composition: Juptm1Ruiz/Jup+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0013906 absent embryonic telencephalon "absence of the paired diverticula of the embryonic telencephalon, from which the forebrain develops" [MGI:Anna]
Show

Allelic Composition: Juptm1Ruiz/Jup+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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