ENSMUSG00000048661


Mus musculus

Features
Gene ID: ENSMUSG00000048661
  
Biological name :Lemd3
  
Synonyms : Lemd3 / LEM domain containing 3
  
Possible biological names infered from orthology : Q9Y2U8
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: D2
Gene start: 120923413
Gene end: 120979332
  
Corresponding Affymetrix probe sets: 10372815 (MoGene1.0st)   1435291_at (Mouse Genome 430 2.0 Array)   1439587_at (Mouse Genome 430 2.0 Array)   1459700_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112661
Ensembl peptide - ENSMUSP00000113103
NCBI entrez gene - 380664     See in Manteia.
MGI - MGI:3580376
RefSeq - NM_001081193
RefSeq Peptide - NP_001074662
swissprot - E9QP59
swissprot - D3YU56
Ensembl - ENSMUSG00000048661
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lemd3ENSDARG00000015824Danio rerio
 LEMD3ENSGALG00000009873Gallus gallus
 LEMD3ENSG00000174106Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lemd2 / Q6DVA0 / LEM domain-containing protein 2 / Q8NC56* / LEM domain containing 2*ENSMUSG0000004485717


Protein motifs (from Interpro)
Interpro ID Name
 IPR003887  LEM domain
 IPR011015  LEM/LEM-like domain superfamily
 IPR011989  Armadillo-like helical
 IPR018996  Man1-Src1p-C-terminal domain
 IPR034394  MAN1, RNA recognition motif
 IPR034997  Inner nuclear membrane protein Man1
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0006997 nucleus organization IEA
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0030514 negative regulation of BMP signaling pathway IEA
 biological_processGO:0032926 negative regulation of activin receptor signaling pathway IEA
 biological_processGO:1902531 regulation of intracellular signal transduction IEA
 cellular_componentGO:0005637 nuclear inner membrane IEA
 cellular_componentGO:0005639 integral component of nuclear inner membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 molecular_functionGO:0003676 nucleic acid binding IEA


Pathways (from Reactome)
Pathway description
Depolymerisation of the Nuclear Lamina


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
Show

Allelic Composition: Man1a2tm1.1Ahe/Man1a2tm1.1Ahe
Genetic Background: either: 129S4/SvJae-Man1a2tm1.1Ahe or (involves: 129S4/SvJae * C57BL/6 * CD-1)

 MP:0000291 enlarged pericardium "extended fibroserous membrane covering the heart and beginning of the great vessels" [J:29971]
Show

Allelic Composition: Man1a2tm1.1Ahe/Man1a2tm1.1Ahe
Genetic Background: either: 129S4/SvJae-Man1a2tm1.1Ahe or (involves: 129S4/SvJae * C57BL/6 * CD-1)

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
Show

Allelic Composition: Man1a2tm1.1Ahe/Man1a2tm1.1Ahe
Genetic Background: either: 129S4/SvJae-Man1a2tm1.1Ahe or (involves: 129S4/SvJae * C57BL/6 * CD-1)

 MP:0003111 abnormal nucleus morphology "abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Man1a2tm1.1Ahe/Man1a2tm1.1Ahe
Genetic Background: either: 129S4/SvJae-Man1a2tm1.1Ahe or (involves: 129S4/SvJae * C57BL/6 * CD-1)

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: Man1a2tm1.1Ahe/Man1a2tm1.1Ahe
Genetic Background: either: 129S4/SvJae-Man1a2tm1.1Ahe or (involves: 129S4/SvJae * C57BL/6 * CD-1)

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
Show

Allelic Composition: Man1a2tm1.1Ahe/Man1a2tm1.1Ahe
Genetic Background: either: 129S4/SvJae-Man1a2tm1.1Ahe or (involves: 129S4/SvJae * C57BL/6 * CD-1)

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Man1a2tm1.1Ahe/Man1a2tm1.1Ahe
Genetic Background: either: 129S4/SvJae-Man1a2tm1.1Ahe or (involves: 129S4/SvJae * C57BL/6 * CD-1)

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Man1a2tm1.1Ahe/Man1a2tm1.1Ahe
Genetic Background: either: 129S4/SvJae-Man1a2tm1.1Ahe or (involves: 129S4/SvJae * C57BL/6 * CD-1)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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