ENSMUSG00000044988


Mus musculus

Features
Gene ID: ENSMUSG00000044988
  
Biological name :Ucn3
  
Synonyms : Q924A4 / Ucn3 / urocortin 3
  
Possible biological names infered from orthology : Q969E3
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: A1
Gene start: 3940688
Gene end: 3945349
  
Corresponding Affymetrix probe sets: 10407431 (MoGene1.0st)   1441439_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000049678
NCBI entrez gene - 83428     See in Manteia.
MGI - MGI:1932970
RefSeq - NM_031250
RefSeq Peptide - NP_112540
swissprot - Q3UFJ9
swissprot - Q924A4
Ensembl - ENSMUSG00000044988
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ucn3lENSDARG00000087241Danio rerio
 UCN3ENSGALG00000032978Gallus gallus
 UCN3ENSG00000178473Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000187  Corticotropin-releasing factor
 IPR024270  Urocortin II/III


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006950 response to stress IEA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007218 neuropeptide signaling pathway TAS
 biological_processGO:0007586 digestion IEA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0009755 hormone-mediated signaling pathway IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0031669 cellular response to nutrient levels IBA
 biological_processGO:0032024 positive regulation of insulin secretion IEA
 biological_processGO:0035902 response to immobilization stress IEA
 biological_processGO:0042594 response to starvation IEA
 biological_processGO:0045838 positive regulation of membrane potential IEA
 biological_processGO:0051412 response to corticosterone IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043196 varicosity IEA
 cellular_componentGO:0043679 axon terminus IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IBA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0005184 neuropeptide hormone activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0051429 corticotropin-releasing hormone receptor binding ISO
 molecular_functionGO:0051431 corticotropin-releasing hormone receptor 2 binding IEA


Pathways (from Reactome)
Pathway description
Class B/2 (Secretin family receptors)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ndufs4tm1.1Rpa/Ndufs4tm1.1Rpa
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Eloatm1Aso/Eloatm1Aso,Trp53tm1Sia/Trp53tm1Sia
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Eloatm1Aso/Eloatm1Aso,Trp53tm1Sia/Trp53tm1Sia
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Eloatm1Aso/Eloatm1Aso,Trp53tm1Sia/Trp53tm1Sia
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0004931 enlarged epididymis "increase in the average size of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Eloatm1Aso/Eloatm1Aso,Trp53tm1Sia/Trp53tm1Sia
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003476 Crhr2 / Q60748 / Corticotropin-releasing factor receptor 2 / Q13324* / corticotropin releasing hormone receptor 2*  / complex / reaction






 

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