ENSMUSG00000045312


Mus musculus

Features
Gene ID: ENSMUSG00000045312
  
Biological name :Lhfpl2
  
Synonyms : Lhfpl2 / LHFPL tetraspan subfamily member 2 protein / Q8BGA2
  
Possible biological names infered from orthology : LHFPL tetraspan subfamily member 2 / Q6ZUX7
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: C3
Gene start: 94057796
Gene end: 94195409
  
Corresponding Affymetrix probe sets: 10406676 (MoGene1.0st)   1434129_s_at (Mouse Genome 430 2.0 Array)   1434130_at (Mouse Genome 430 2.0 Array)   1443185_at (Mouse Genome 430 2.0 Array)   1454847_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113468
Ensembl peptide - ENSMUSP00000152453
Ensembl peptide - ENSMUSP00000152241
Ensembl peptide - ENSMUSP00000117113
Ensembl peptide - ENSMUSP00000113786
Ensembl peptide - ENSMUSP00000062239
Ensembl peptide - ENSMUSP00000112655
NCBI entrez gene - 218454     See in Manteia.
MGI - MGI:2145236
RefSeq - XM_011244641
RefSeq - XM_011244642
RefSeq - XM_011244643
RefSeq - XM_011244644
RefSeq - NM_172589
RefSeq - XM_011244639
RefSeq - XM_011244640
RefSeq Peptide - NP_766177
swissprot - Q8BGA2
swissprot - D3Z4C4
swissprot - A0A1Y7VNJ3
swissprot - A0A1Y7VJ20
swissprot - D3Z698
Ensembl - ENSMUSG00000045312
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lhfpl2bENSDARG00000098153Danio rerio
 LHFPL2ENSGALG00000004437Gallus gallus
 LHFPL2ENSG00000145685Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lhfp / Q8BM86 / LHFPL tetraspan subfamily member 6 protein / Q9Y693* / LHFPL6* / LHFPL tetraspan subfamily member 6*ENSMUSG0000004833224
Lhfpl4 / Q5U4E0 / LHFPL tetraspan subfamily member 4 protein / Q7Z7J7* / LHFPL tetraspan subfamily member 4*ENSMUSG0000004287323
Lhfpl1 / Q80SV1 / LHFPL tetraspan subfamily member 1 protein / Q86WI0* / LHFPL tetraspan subfamily member 1*ENSMUSG0000004170022
Lhfpl3 / LHFPL tetraspan subfamily member 3 protein isoform 1 / Q86UP9* / LHFPL tetraspan subfamily member 3*ENSMUSG0000010637921
Lhfpl5 / Q4KL25 / LHFPL tetraspan subfamily member 5 protein / Q8TAF8* / LHFPL tetraspan subfamily member 5*ENSMUSG0000006225220


Protein motifs (from Interpro)
Interpro ID Name
 IPR019372  Lipoma HMGIC fusion partner-like protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007338 single fertilization IEA
 biological_processGO:0046545 development of primary female sexual characteristics IMP
 biological_processGO:0046546 development of primary male sexual characteristics IMP
 biological_processGO:1905516 positive regulation of fertilization IMP
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
Platelet degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001119 abnormal female reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that bears the offspring" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ripply3tm1Sjt/Ripply3+,Tbx1tm1Bem/Tbx1+
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J * SJL

 MP:0001120 abnormal uterus morphology "malformation or absence of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ripply3tm1Sjt/Ripply3+,Tbx1tm1Bem/Tbx1+
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J * SJL

 MP:0001136 dilated cervix "stretched or enlarged lower opening of the uterus to the vagina" [J:50844]
Show

Allelic Composition: Ripply3tm1Sjt/Ripply3+,Tbx1tm1Bem/Tbx1+
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J * SJL

 MP:0001139 abnormal vagina morphology "malformation of the female reproductive canal located between the uterus and the vulva" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ripply3tm1Sjt/Ripply3+,Tbx1tm1Bem/Tbx1+
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J * SJL

 MP:0001144 fused vaginal opening "condition in which the external vaginal opening is closed by the adherence of the epithelium of the vagina" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ripply3tm1Sjt/Ripply3+,Tbx1tm1Bem/Tbx1+
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J * SJL

 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ripply3tm1Sjt/Ripply3+,Tbx1tm1Bem/Tbx1+
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J * SJL

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Ripply3tm1Sjt/Ripply3+,Tbx1tm1Bem/Tbx1+
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J * SJL

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Ripply3tm1Sjt/Ripply3+,Tbx1tm1Bem/Tbx1+
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J * SJL

 MP:0002059 abnormal seminal gland morphology "anomalous structure of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ripply3tm1Sjt/Ripply3+,Tbx1tm1Bem/Tbx1+
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J * SJL

 MP:0002638 abnormal pupillary reflex "alterations or failure of the pupil to change in diamater as a reflex response to any stimulus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ripply3tm1Sjt/Ripply3+,Tbx1tm1Bem/Tbx1+
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J * SJL

 MP:0002750 exophthalmos "protrusion of one or both eyeballs" [J:47965, il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ripply3tm1Sjt/Ripply3+,Tbx1tm1Bem/Tbx1+
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J * SJL

 MP:0002769 abnormal vas deferens morphology "malformation of the secretory duct of the testicle that carries spermatozoa, running from the epididymis, of which it is the continuation, to the prostatic urethra where it terminates to form ejaculatory duct" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ripply3tm1Sjt/Ripply3+,Tbx1tm1Bem/Tbx1+
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J * SJL

 MP:0003315 abnormal perineum morphology "malformation in the area between the genital organs and the anus that lies beneath the pelvic diaphragm" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ripply3tm1Sjt/Ripply3+,Tbx1tm1Bem/Tbx1+
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J * SJL

 MP:0003531 abnormal vagina development "abnormal morphogenesis of the female reproductive canal located between the uterus and the vulva" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Ripply3tm1Sjt/Ripply3+,Tbx1tm1Bem/Tbx1+
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J * SJL

 MP:0003936 abnormal reproductive system development "developmental anomaly of any of the organs involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ripply3tm1Sjt/Ripply3+,Tbx1tm1Bem/Tbx1+
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J * SJL

 MP:0004906 enlarged uterus 
Show

Allelic Composition: Ripply3tm1Sjt/Ripply3+,Tbx1tm1Bem/Tbx1+
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J * SJL

 MP:0008511 thin retinal inner nuclear layer "reduced thickness of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ripply3tm1Sjt/Ripply3+,Tbx1tm1Bem/Tbx1+
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J * SJL

 MP:0009085 abnormal uterine horn morphology "any structural anomaly of either one of the pair of tubular extensions from the uterine body where the uterus and the uterine tubes meet; uterine horns are anterior Mullerian duct-derived structures" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ripply3tm1Sjt/Ripply3+,Tbx1tm1Bem/Tbx1+
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J * SJL

 MP:0009208 abnormal female genitalia morphology "any structural anomaly of the feminine organs of reproduction or generation, external or internal" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ripply3tm1Sjt/Ripply3+,Tbx1tm1Bem/Tbx1+
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J * SJL

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Ripply3tm1Sjt/Ripply3+,Tbx1tm1Bem/Tbx1+
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J * SJL

 MP:0013852 abnormal Mullerian duct topology "aberrant position of the transient embryonic drainage tubes of the embryonic kidney (mesonephric tubules) that empty into the cloaca and in the female develop into the oviducts, uterus, and vagina" [ISBN:0-683-40008-8]
Show

Allelic Composition: Ripply3tm1Sjt/Ripply3+,Tbx1tm1Bem/Tbx1+
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J * SJL

 MP:0014017 abnormal Wolffian duct connection "aberrant attachment or incomplete connection of the transient embryonic drainage tubes of the embryonic kidney (mesonephric tubules) to the cloaca " [ISBN:0-683-40008-8]
Show

Allelic Composition: Ripply3tm1Sjt/Ripply3+,Tbx1tm1Bem/Tbx1+
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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