ENSMUSG00000062252


Mus musculus

Features
Gene ID: ENSMUSG00000062252
  
Biological name :Lhfpl5
  
Synonyms : Lhfpl5 / LHFPL tetraspan subfamily member 5 protein / Q4KL25
  
Possible biological names infered from orthology : LHFPL tetraspan subfamily member 5 / Q8TAF8
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: A3.3
Gene start: 28575718
Gene end: 28583593
  
Corresponding Affymetrix probe sets: 10443383 (MoGene1.0st)   1429266_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000079598
NCBI entrez gene - 328789     See in Manteia.
MGI - MGI:1915382
RefSeq - NM_026571
RefSeq Peptide - NP_080847
swissprot - Q4KL25
Ensembl - ENSMUSG00000062252
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lhfpl5aENSDARG00000045023Danio rerio
 lhfpl5bENSDARG00000056458Danio rerio
 LHFPL5ENSGALG00000039170Gallus gallus
 LHFPL5ENSG00000197753Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lhfpl3 / LHFPL tetraspan subfamily member 3 protein isoform 1 / Q86UP9* / LHFPL tetraspan subfamily member 3*ENSMUSG0000010637965
Lhfpl4 / Q5U4E0 / LHFPL tetraspan subfamily member 4 protein / Q7Z7J7* / LHFPL tetraspan subfamily member 4*ENSMUSG0000004287360
Lhfp / Q8BM86 / LHFPL tetraspan subfamily member 6 protein / Q9Y693* / LHFPL6* / LHFPL tetraspan subfamily member 6*ENSMUSG0000004833221
Lhfpl2 / Q8BGA2 / LHFPL tetraspan subfamily member 2 protein / Q6ZUX7* / LHFPL tetraspan subfamily member 2*ENSMUSG0000004531220
Lhfpl1 / Q80SV1 / LHFPL tetraspan subfamily member 1 protein / Q86WI0* / LHFPL tetraspan subfamily member 1*ENSMUSG0000004170019


Protein motifs (from Interpro)
Interpro ID Name
 IPR019372  Lipoma HMGIC fusion partner-like protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0007605 sensory perception of sound IMP
 biological_processGO:0050910 detection of mechanical stimulus involved in sensory perception of sound IMP
 biological_processGO:0060088 auditory receptor cell stereocilium organization IMP
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0032421 stereocilium bundle IDA
 cellular_componentGO:0032426 stereocilium tip IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000043 organ of Corti degeneration "a retrogressive impairment of function or destruction of the highly specialized epithelium in the floor of the ductus cochlearis" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Abca1tm1.1Jp/Abca1tm1.1Jp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
Show

Allelic Composition: Abca1tm1.1Jp/Abca1tm1.1Jp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Lhfpl5hscy/Lhfpl5hscy
Genetic Background: involves: B6(MOR)-Tmhshscy/J * CAST/Ei

Allelic Composition: Lhfpl5hscy-2J/Lhfpl5hscy-2J
Genetic Background: C57BL/6J-Lhfpl5hscy-2J/J

 MP:0001395 bi-directional circling "circling behavior exhibited in both clockwise and counterclockwise directions" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lhfpl5hscy-2J/Lhfpl5hscy-2J
Genetic Background: C57BL/6J-Lhfpl5hscy-2J/J

Allelic Composition: Lhfpl5tm1Kjn/Lhfpl5tm1Kjn
Genetic Background: B6.129-Lhfpl5tm1Kjn/Kjn

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
Show

Allelic Composition: Abca1tm1.1Jp/Abca1tm1.1Jp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
Show

Allelic Composition: Kcnq1vtg-3J/Kcnq1vtg-3J
Genetic Background: C57BL/6J-Kcnq1vtg-3J/J

 MP:0001967 deafness "inability to hear" [J:57651]
Show

Allelic Composition: Abca1tm1.1Jp/Abca1tm1.1Jp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Lhfpl5hscy/Lhfpl5hscy
Genetic Background: involves: B6(MOR)-Tmhshscy/J * CAST/Ei

Allelic Composition: Lhfpl5hscy-2J/Lhfpl5hscy-2J
Genetic Background: C57BL/6J-Lhfpl5hscy-2J/J

Allelic Composition: Lhfpl5tm1Kjn/Lhfpl5tm1Kjn
Genetic Background: B6.129-Lhfpl5tm1Kjn/Kjn

 MP:0002730 head shaking "compulsive movement of the head in the horizontal plane" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:274]
Show

Allelic Composition: Abca1tm1.1Jp/Abca1tm1.1Jp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Lhfpl5hscy-2J/Lhfpl5hscy-2J
Genetic Background: C57BL/6J-Lhfpl5hscy-2J/J

 MP:0003986 small cochlear ganglion "reduced size of the cochlear ganglion or of the sensory neuron cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Abca1tm1.1Jp/Abca1tm1.1Jp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004362 cochlear hair cell degeneration "degeneration or loss of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abca1tm1.1Jp/Abca1tm1.1Jp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004393 abnormal cochlear inner hair cell morphology "any structural abnormality in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there is a single row of flask-shaped inner hair cells tightly surrounded by supporting interphalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a more or less linear (or shallow) U-shaped pattern extend from the cell s surface through the cuticular plate into the endolymphic space inferior to the tectorial membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lhfpl5tm1Kjn/Lhfpl5tm1Kjn
Genetic Background: B6.129-Lhfpl5tm1Kjn/Kjn

 MP:0004398 cochlear inner hair cell degeneration "degeneration or loss of the single row of flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abca1tm1.1Jp/Abca1tm1.1Jp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004404 cochlear outer hair cell degeneration "degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abca1tm1.1Jp/Abca1tm1.1Jp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Lhfpl5tm1Kjn/Lhfpl5tm1Kjn
Genetic Background: B6.129-Lhfpl5tm1Kjn/Kjn

 MP:0004527 abnormal outer hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typical V or W-like pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear OHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest (outermost) row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lhfpl5tm1Kjn/Lhfpl5tm1Kjn
Genetic Background: B6.129-Lhfpl5tm1Kjn/Kjn

 MP:0005191 head tilt "condition in which the portion of the body containing the brain and organs of sight, hearing, taste, and smell lists to the side" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lhfpl5hscy-2J/Lhfpl5hscy-2J
Genetic Background: C57BL/6J-Lhfpl5hscy-2J/J

 MP:0005307 head tossing "compulsive flailing of the head in multiple directions" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lhfpl5tm1Kjn/Lhfpl5tm1Kjn
Genetic Background: B6.129-Lhfpl5tm1Kjn/Kjn

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Abca1tm1.1Jp/Abca1tm1.1Jp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Lhfpl5hscy/Lhfpl5hscy
Genetic Background: involves: B6(MOR)-Tmhshscy/J * CAST/Ei

Allelic Composition: Lhfpl5hscy-2J/Lhfpl5hscy-2J
Genetic Background: C57BL/6J-Lhfpl5hscy-2J/J

Allelic Composition: Lhfpl5tm1Kjn/Lhfpl5tm1Kjn
Genetic Background: B6.129-Lhfpl5tm1Kjn/Kjn

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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