ENSMUSG00000045903


Mus musculus

Features
Gene ID: ENSMUSG00000045903
  
Biological name :Npas4
  
Synonyms : Neuronal PAS domain-containing protein 4 / Npas4 / Q8BGD7
  
Possible biological names infered from orthology : neuronal PAS domain protein 4 / Q8IUM7
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 4984355
Gene end: 4989971
  
Corresponding Affymetrix probe sets: 10464905 (MoGene1.0st)   1459372_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000062992
NCBI entrez gene - 225872     See in Manteia.
MGI - MGI:2664186
RefSeq - XM_011248619
RefSeq - NM_153553
RefSeq - XM_006531720
RefSeq - XM_006531721
RefSeq Peptide - NP_705781
swissprot - Q8BGD7
Ensembl - ENSMUSG00000045903
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CR388166.1ENSDARG00000087753Danio rerio
 npas4aENSDARG00000055752Danio rerio
 ENSGALG00000041074Gallus gallus
 NPAS4ENSG00000174576Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR013655  PAS fold-3
 IPR035965  PAS domain superfamily
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007612 learning IMP
 biological_processGO:0007614 short-term memory IMP
 biological_processGO:0007616 long-term memory IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0032228 regulation of synaptic transmission, GABAergic IMP
 biological_processGO:0035176 social behavior IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048167 regulation of synaptic plasticity IMP
 biological_processGO:0060079 excitatory postsynaptic potential IMP
 biological_processGO:0060080 inhibitory postsynaptic potential IMP
 biological_processGO:0071386 cellular response to corticosterone stimulus IDA
 biological_processGO:1904862 inhibitory synapse assembly IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0098794 postsynapse IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA
 molecular_functionGO:0001012 RNA polymerase II regulatory region DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000243 myoclonus "involuntary shock-like contractions, variable in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscles; generally due to a central nervous system lesion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Npas4tm1Ooe/Npas4tm1Ooe
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
Show

Allelic Composition: Dock1tm1Jfco/Dock1+,Dock5Gt(AN0268)Wtsi/Dock5Gt(AN0268)Wtsi
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Dock1tm1Jfco/Dock1+,Dock5Gt(AN0268)Wtsi/Dock5Gt(AN0268)Wtsi
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dock1tm1Jfco/Dock1+,Dock5Gt(AN0268)Wtsi/Dock5Gt(AN0268)Wtsi
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dock1tm1Jfco/Dock1+,Dock5Gt(AN0268)Wtsi/Dock5Gt(AN0268)Wtsi
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Npas4tm1Ooe/Npas4tm1Ooe
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Npas4tm1Ooe/Npas4+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Npas4tm1Ooe/Npas4tm1Ooe
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Npas4tm1Ooe/Npas4tm1Ooe
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Dock1tm1Jfco/Dock1+,Dock5Gt(AN0268)Wtsi/Dock5Gt(AN0268)Wtsi
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Npas4tm1Ooe/Npas4tm1Ooe
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dock1tm1Jfco/Dock1+,Dock5Gt(AN0268)Wtsi/Dock5Gt(AN0268)Wtsi
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Npas4tm1Ooe/Npas4tm1Ooe
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008235 increased susceptibility to neuronal excitotoxicity "greater than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Npas4tm1Ooe/Npas4tm1Ooe
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Npas4tm1Ooe/Npas4tm1Ooe
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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