ENSMUSG00000046275


Mus musculus

Features
Gene ID: ENSMUSG00000046275
  
Biological name :Tusc5
  
Synonyms : Q8C838 / tumor suppressor candidate 5 / Tusc5
  
Possible biological names infered from orthology : Q8IXB3
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B5
Gene start: 76679808
Gene end: 76698664
  
Corresponding Affymetrix probe sets: 10378787 (MoGene1.0st)   1441096_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000061634
NCBI entrez gene - 237858     See in Manteia.
MGI - MGI:3029307
RefSeq - NM_177709
RefSeq Peptide - NP_808377
swissprot - Q8C838
Ensembl - ENSMUSG00000046275
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tusc5aENSDARG00000090481Danio rerio
 tusc5bENSDARG00000094675Danio rerio
 TUSC5ENSG00000184811Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prrt2 / E9PUL5 / Proline-rich transmembrane protein 2 / Q7Z6L0* / AC009133.6*ENSMUSG0000004511431
Tmem233 / transmembrane protein 233 / B4DJY2*ENSMUSG0000007927829


Protein motifs (from Interpro)
Interpro ID Name
 IPR007593  CD225/Dispanin family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009607 response to biotic stimulus IEA
 biological_processGO:0032869 cellular response to insulin stimulus IMP
 biological_processGO:0044381 glucose import in response to insulin stimulus IMP
 biological_processGO:0045026 plasma membrane fusion IMP
 biological_processGO:0072659 protein localization to plasma membrane IMP
 biological_processGO:0099638 endosome to plasma membrane protein transport IMP
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Shank3tm1.2Yhj/Shank3tm1.2Yhj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Shank3tm1.2Yhj/Shank3tm1.2Yhj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001560 abnormal circulating insulin level "anomalous blood concentration of this polypeptide hormone, secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Shank3tm1.2Yhj/Shank3tm1.2Yhj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Shank3tm1.2Yhj/Shank3tm1.2Yhj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Shank3tm1.2Yhj/Shank3tm1.2Yhj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0013277 abnormal fasted circulating glucose level "any anomaly in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
Show

Allelic Composition: Shank3tm1.2Yhj/Shank3tm1.2Yhj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0030017 decreased adipocyte glucose uptake "reduced ability of adipocytes to take in glucose" [MGI:anna]
Show

Allelic Composition: Shank3tm1.2Yhj/Shank3tm1.2Yhj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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