ENSMUSG00000045114


Mus musculus

Features
Gene ID: ENSMUSG00000045114
  
Biological name :Prrt2
  
Synonyms : E9PUL5 / Proline-rich transmembrane protein 2 / Prrt2
  
Possible biological names infered from orthology : AC009133.6 / Q7Z6L0
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F3
Gene start: 127017531
Gene end: 127021211
  
Corresponding Affymetrix probe sets: 10568135 (MoGene1.0st)   1429113_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124520
Ensembl peptide - ENSMUSP00000144451
Ensembl peptide - ENSMUSP00000144042
Ensembl peptide - ENSMUSP00000143833
NCBI entrez gene - 69017     See in Manteia.
MGI - MGI:1916267
RefSeq - XM_017312280
RefSeq - NM_001102563
RefSeq Peptide - NP_001096033
swissprot - A0A0J9YTS8
swissprot - A0A0J9YV24
swissprot - E9PUL5
swissprot - A0A0J9YU72
Ensembl - ENSMUSG00000045114
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prrt2ENSDARG00000103588Danio rerio
 AC009133.6ENSG00000280893Homo sapiens
 PRRT2ENSG00000167371Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tusc5 / Q8C838 / tumor suppressor candidate 5 / Q8IXB3*ENSMUSG0000004627516
Tmem233 / transmembrane protein 233 / B4DJY2*ENSMUSG0000007927813


Protein motifs (from Interpro)
Interpro ID Name
 IPR007593  CD225/Dispanin family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009607 response to biotic stimulus IEA
 biological_processGO:0031629 synaptic vesicle fusion to presynaptic active zone membrane IMP
 biological_processGO:0035544 negative regulation of SNARE complex assembly IMP
 biological_processGO:0050884 neuromuscular process controlling posture ISO
 biological_processGO:1905513 negative regulation of short-term synaptic potentiation IMP
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0008021 synaptic vesicle IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031982 vesicle IDA
 cellular_componentGO:0042734 presynaptic membrane IDA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043679 axon terminus IDA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0098793 presynapse IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017075 syntaxin-1 binding IDA
 molecular_functionGO:0017124 SH3 domain binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001401 jumpy "marked by fitful, jerky movements" [J:22295]
Show

Allelic Composition: Mapk14tm1.1Otsu/Mapk14tm1.2Otsu,Slc6a3tm1(cre)Xz/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001441 increased grooming behavior "increased amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk14tm1.1Otsu/Mapk14tm1.2Otsu,Slc6a3tm1(cre)Xz/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001496 audiogenic seizures "a reflex seizure triggered by loud noises" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk14tm1.1Otsu/Mapk14tm1.2Otsu,Slc6a3tm1(cre)Xz/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
Show

Allelic Composition: Mapk14tm1.1Otsu/Mapk14tm1.2Otsu,Slc6a3tm1(cre)Xz/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk14tm1.1Otsu/Mapk14tm1.2Otsu,Slc6a3tm1(cre)Xz/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
Show

Allelic Composition: Mapk14tm1.1Otsu/Mapk14tm1.2Otsu,Slc6a3tm1(cre)Xz/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Mapk14tm1.1Otsu/Mapk14tm1.2Otsu,Slc6a3tm1(cre)Xz/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004647 decreased lumbar vertebrae number "reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Izumo1rtm2a(KOMP)Wtsi/Izumo1rtm2a(KOMP)Wtsi
Genetic Background: C57BL/6N-Izumo1rtm2a(KOMP)Wtsi/Wtsi

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mapk14tm1.1Otsu/Mapk14tm1.2Otsu,Slc6a3tm1(cre)Xz/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004859 abnormal synaptic plasticity "anomaly in the ability of a synapse to change its strength as a result of successive activations" [MESH:National Library of Medicine_Medical Subject Headings, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mapk14tm1.1Otsu/Mapk14tm1.2Otsu,Slc6a3tm1(cre)Xz/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005424 jerky movement "continuous, abrupt, faltering motions of the whole body or a portion of the body" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk14tm1.1Otsu/Mapk14tm1.2Otsu,Slc6a3tm1(cre)Xz/0
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Prrt2tm1a(KOMP)Wtsi/Prrt2+
Genetic Background: C57BL/6N-Atm1Brd Prrt2tm1a(KOMP)Wtsi/Wtsi

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
Show

Allelic Composition: Mapk14tm1.1Otsu/Mapk14tm1.2Otsu,Slc6a3tm1(cre)Xz/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008911 induced hyperactivity "increased physical activity following stimulation such as handling, touching or noise" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mapk14tm1.1Otsu/Mapk14tm1.2Otsu,Slc6a3tm1(cre)Xz/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0010101 increased sacral vertebrae number "increase of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Izumo1rtm2a(KOMP)Wtsi/Izumo1rtm2a(KOMP)Wtsi
Genetic Background: C57BL/6N-Izumo1rtm2a(KOMP)Wtsi/Wtsi

 MP:0010323 retropulsion "a tendency to step or walk backwards" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mapk14tm1.1Otsu/Mapk14tm1.2Otsu,Slc6a3tm1(cre)Xz/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0020357 abnormal excitatory synapse morphology "any structural anomaly of a synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell" [GO:0060076]
Show

Allelic Composition: Mapk14tm1.1Otsu/Mapk14tm1.2Otsu,Slc6a3tm1(cre)Xz/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0020358 abnormal inhibitory synapse morphology "any structural anomaly in a synapse in which an action potential in the presynaptic cell reduces the probability of an action potential occurring in the postsynaptic cell" [GO:0060077]
Show

Allelic Composition: Mapk14tm1.1Otsu/Mapk14tm1.2Otsu,Slc6a3tm1(cre)Xz/0
Genetic Background: involves: 129S1/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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