ENSMUSG00000046607


Mus musculus

Features
Gene ID: ENSMUSG00000046607
  
Biological name :Hrk
  
Synonyms : Activator of apoptosis harakiri / Hrk / P62816
  
Possible biological names infered from orthology : harakiri, BCL2 interacting protein / O00198
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: F
Gene start: 118164648
Gene end: 118189478
  
Corresponding Affymetrix probe sets: 10524969 (MoGene1.0st)   1439854_at (Mouse Genome 430 2.0 Array)   1450366_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000057532
NCBI entrez gene - 12123     See in Manteia.
MGI - MGI:1201608
RefSeq - NM_007545
RefSeq Peptide - NP_031571
swissprot - P62816
Ensembl - ENSMUSG00000046607
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HRKENSG00000135116Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR017249  Activator of apoptosis harakiri
 IPR020728  Apoptosis regulator, Bcl-2, BH3 motif, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0032464 positive regulation of protein homooligomerization IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0090200 positive regulation of release of cytochrome c from mitochondria IEA
 cellular_componentGO:0005739 mitochondrion IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
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Allelic Composition: Hectd1opm/Hectd1opm
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0001011 abnormal superior cervical ganglion morphology "malformation or absence of the group of neurons that is the largest of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ncam1tm1Cgn/Ncam1tm1Cgn
Genetic Background: involves: C57BL/6J

 MP:0001076 abnormal hypoglossal nerve morphology "malformation or misprojection of motor axons to the tongue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
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Allelic Composition: Ncam1tm1Cgn/Ncam1tm1Cgn
Genetic Background: involves: C57BL/6J

 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Ncam1tm1Cgn/Ncam1tm1Cgn
Genetic Background: involves: C57BL/6J

Allelic Composition: Hrktm1Ast/Hrktm1Ast
Genetic Background: C57BL/6-Hrktm1Ast

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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