ENSMUSG00000047139


Mus musculus

Features
Gene ID: ENSMUSG00000047139
  
Biological name :Cd24a
  
Synonyms : Cd24a / P24807 / Signal transducer CD24
  
Possible biological names infered from orthology : CD24 / CD24 molecule
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: B2
Gene start: 43578284
Gene end: 43584265
  
Corresponding Affymetrix probe sets: 10362896 (MoGene1.0st)   1416034_at (Mouse Genome 430 2.0 Array)   1437502_x_at (Mouse Genome 430 2.0 Array)   1448182_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000148921
Ensembl peptide - ENSMUSP00000057983
NCBI entrez gene - 12484     See in Manteia.
MGI - MGI:88323
RefSeq - NM_009846
RefSeq Peptide - NP_033976
swissprot - A0A1L1SQ70
swissprot - P24807
swissprot - Q3THW4
Ensembl - ENSMUSG00000047139
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CD24ENSG00000272398Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR028029  Signal transducer CD24


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia ISS
 biological_processGO:0001775 cell activation ISS
 biological_processGO:0001959 regulation of cytokine-mediated signaling pathway IMP
 biological_processGO:0002237 response to molecule of bacterial origin IDA
 biological_processGO:0002329 pre-B cell differentiation IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002523 leukocyte migration involved in inflammatory response IMP
 biological_processGO:0002842 positive regulation of T cell mediated immune response to tumor cell IDA
 biological_processGO:0002863 positive regulation of inflammatory response to antigenic stimulus IMP
 biological_processGO:0002904 positive regulation of B cell apoptotic process IDA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IDA
 biological_processGO:0007159 leukocyte cell-cell adhesion IDA
 biological_processGO:0007166 cell surface receptor signaling pathway IDA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration ISS
 biological_processGO:0007274 neuromuscular synaptic transmission IMP
 biological_processGO:0007406 negative regulation of neuroblast proliferation IMP
 biological_processGO:0008637 apoptotic mitochondrial changes IDA
 biological_processGO:0010976 positive regulation of neuron projection development IGI
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0022407 regulation of cell-cell adhesion IDA
 biological_processGO:0022409 positive regulation of cell-cell adhesion IDA
 biological_processGO:0030262 apoptotic nuclear changes IDA
 biological_processGO:0030889 negative regulation of B cell proliferation IDA
 biological_processGO:0031175 neuron projection development IMP
 biological_processGO:0031295 T cell costimulation ISS
 biological_processGO:0032597 B cell receptor transport into membrane raft ISS
 biological_processGO:0032600 chemokine receptor transport out of membrane raft IMP
 biological_processGO:0032715 negative regulation of interleukin-6 production IMP
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IMP
 biological_processGO:0032913 negative regulation of transforming growth factor beta3 production ISS
 biological_processGO:0033625 positive regulation of integrin activation IMP
 biological_processGO:0033630 positive regulation of cell adhesion mediated by integrin IMP
 biological_processGO:0033632 regulation of cell-cell adhesion mediated by integrin IDA
 biological_processGO:0033634 positive regulation of cell-cell adhesion mediated by integrin IDA
 biological_processGO:0034107 negative regulation of erythrocyte clearance IMP
 biological_processGO:0034109 homotypic cell-cell adhesion IMP
 biological_processGO:0034119 negative regulation of erythrocyte aggregation IMP
 biological_processGO:0042103 positive regulation of T cell homeostatic proliferation IMP
 biological_processGO:0042104 positive regulation of activated T cell proliferation ISS
 biological_processGO:0042325 regulation of phosphorylation ISS
 biological_processGO:0042632 cholesterol homeostasis IMP
 biological_processGO:0043406 positive regulation of MAP kinase activity ISS
 biological_processGO:0043408 regulation of MAPK cascade ISS
 biological_processGO:0043627 response to estrogen ISS
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045577 regulation of B cell differentiation IMP
 biological_processGO:0045665 negative regulation of neuron differentiation IMP
 biological_processGO:0045730 respiratory burst ISS
 biological_processGO:0046014 negative regulation of T cell homeostatic proliferation IMP
 biological_processGO:0046641 positive regulation of alpha-beta T cell proliferation IMP
 biological_processGO:0048488 synaptic vesicle endocytosis IMP
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0050768 negative regulation of neurogenesis IMP
 biological_processGO:0050850 positive regulation of calcium-mediated signaling IDA
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IEA
 biological_processGO:0071638 negative regulation of monocyte chemotactic protein-1 production IMP
 biological_processGO:0072112 glomerular visceral epithelial cell differentiation ISS
 biological_processGO:0072139 glomerular parietal epithelial cell differentiation ISS
 biological_processGO:0097190 apoptotic signaling pathway IDA
 biological_processGO:0106015 negative regulation of inflammatory response to wounding IPI
 biological_processGO:0106016 positive regulation of inflammatory response to wounding IMP
 biological_processGO:2000768 positive regulation of nephron tubule epithelial cell differentiation ISS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0031362 anchored component of external side of plasma membrane IEA
 cellular_componentGO:0031528 microvillus membrane IDA
 cellular_componentGO:0045121 membrane raft ISS
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0060170 ciliary membrane IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding ISS
 molecular_functionGO:0030246 carbohydrate binding IDA
 molecular_functionGO:0030296 protein tyrosine kinase activator activity ISS
 molecular_functionGO:0030544 Hsp70 protein binding IDA
 molecular_functionGO:0051879 Hsp90 protein binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Insl3tm1Par/Insl3+
Genetic Background: involves: 129/Sv * CD-1

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Insl3tm1Par/Insl3+
Genetic Background: involves: 129/Sv * CD-1

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Insl3tm1Par/Insl3+
Genetic Background: involves: 129/Sv * CD-1

 MP:0003656 abnormal erythrocyte physiology "functional anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Insl3tm1Par/Insl3+
Genetic Background: involves: 129/Sv * CD-1

 MP:0003657 abnormal erythrocyte lysis "increase or decrease in the ability of RBCs to withstand changes in osmolarity" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Insl3tm1Par/Insl3+
Genetic Background: involves: 129/Sv * CD-1

 MP:0004179 transmission ratio distortion "the occurence of an allele or haplotype in the offspring of an organism at skewed Mendelian ratios" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Insl3tm1Par/Insl3+
Genetic Background: involves: 129/Sv * CD-1

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Insl3tm1Par/Insl3+
Genetic Background: involves: 129/Sv * CD-1

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Insl3tm1Par/Insl3+
Genetic Background: involves: 129/Sv * CD-1

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Insl3tm1Par/Insl3+
Genetic Background: involves: 129/Sv * CD-1

 MP:0020455 increased erythrocyte aggregation "increase in the ability of an erythrocyte to adhere to one or more other erythrocytes via adhesion molecules" [GO:0034117, MGI:smb]
Show

Allelic Composition: Insl3tm1Par/Insl3+
Genetic Background: involves: 129/Sv * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000047139 Cd24a / P24807 / Signal transducer CD24 / CD24* / CD24 molecule*  / complex / reaction






 

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