ENSMUSG00000047261


Mus musculus

Features
Gene ID: ENSMUSG00000047261
  
Biological name :Gap43
  
Synonyms : Gap43 / Neuromodulin / P06837
  
Possible biological names infered from orthology : growth associated protein 43 / P17677
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: B4
Gene start: 42248442
Gene end: 42340651
  
Corresponding Affymetrix probe sets: 10439514 (MoGene1.0st)   1423537_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099881
NCBI entrez gene - 14432     See in Manteia.
MGI - MGI:95639
RefSeq - NM_008083
RefSeq Peptide - NP_032109
swissprot - P06837
Ensembl - ENSMUSG00000047261
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gap43ENSDARG00000099744Danio rerio
 GAP43ENSGALG00000015089Gallus gallus
 GAP43ENSG00000172020Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR001422  Neuromodulin (GAP-43)
 IPR017454  Neuromodulin (GAP-43), C-terminal
 IPR018243  Neuromodulin, palmitoylation site
 IPR018947  Neuromodulin gap junction N-terminal
 IPR033137  Neuromodulin, phosphorylation site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0010001 glial cell differentiation IMP
 biological_processGO:0016198 axon choice point recognition IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0042246 tissue regeneration IEA
 biological_processGO:0045165 cell fate commitment IMP
 biological_processGO:0051489 regulation of filopodium assembly IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0031527 filopodium membrane IEA
 cellular_componentGO:0032584 growth cone membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0071944 cell periphery IDA
 molecular_functionGO:0001786 phosphatidylserine binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0035727 lysophosphatidic acid binding IEA
 molecular_functionGO:1901981 phosphatidylinositol phosphate binding IEA


Pathways (from Reactome)
Pathway description
L1CAM interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Lpltm1Sem/Lpltm1Sem
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gap43tm1Kmr/Gap43tm1Kmr
Genetic Background: B6.129S1-Gap43tm1Kmr

 MP:0000861 disorganized barrel cortex "derangement of the pattern of the discrete functional units of the somatosensory cortex that processes tactile information derived from the vibrissae" [Principles of Neural Science:ISBN 0-8385-8034-3, J:64064]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Lpltm1Sem/Lpltm1Sem
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gap43tm1Kmr/Gap43tm1Kmr
Genetic Background: B6.129S1-Gap43tm1Kmr

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Gap43tm1a(EUCOMM)Wtsi/Gap43+
Genetic Background: B6JTyr;B6N-Gap43tm1a(EUCOMM)Wtsi/Wtsi

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Mmp12tm1Sds/Mmp12tm1Sds,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Gap43tm1a(EUCOMM)Wtsi/Gap43+
Genetic Background: B6JTyr;B6N-Gap43tm1a(EUCOMM)Wtsi/Wtsi

 MP:0001332 abnormal optic nerve innervation "misprojection or aberrant target finding of the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mmp12tm1Sds/Mmp12tm1Sds,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0001334 absent optic tract "absence of the set of cell bodies and nerve fibers conducting impulses from the retina to the cerebral cortex" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mmp12tm1Sds/Mmp12tm1Sds,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mmp12tm1Sds/Mmp12tm1Sds,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0002961 abnormal axon guidance "defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Lpltm1Sem/Lpltm1Sem
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gap43tm1Kmr/Gap43tm1Kmr
Genetic Background: B6.129S1-Gap43tm1Kmr

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Lpltm1Sem/Lpltm1Sem
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gap43tm1Kmr/Gap43tm1Kmr
Genetic Background: B6.129S1-Gap43tm1Kmr

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gap43tm1Kmr/Gap43tm1Kmr
Genetic Background: B6.129S1-Gap43tm1Kmr

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mmp12tm1Sds/Mmp12tm1Sds,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Lpltm1Sem/Lpltm1Sem
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gap43tm1Kmr/Gap43tm1Kmr
Genetic Background: B6.129S1-Gap43tm1Kmr

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Lpltm1Sem/Lpltm1Sem
Genetic Background: involves: 129P2/OlaHsd

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Mmp12tm1Sds/Mmp12tm1Sds,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Gap43tm1Kmr/Gap43tm1Kmr
Genetic Background: B6.129S1-Gap43tm1Kmr

 MP:0020549 increased optic chiasm size "increased size of the optic chiasm" [MGI:smb]
Show

Allelic Composition: Mmp12tm1Sds/Mmp12tm1Sds,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028670 Lypla2 / Q9WTL7 / Acyl-protein thioesterase 2 / O95372* / lysophospholipase II*  / reaction






 

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