ENSMUSG00000047897


Mus musculus

Features
Gene ID: ENSMUSG00000047897
  
Biological name :Ripply2
  
Synonyms : Protein ripply2 / Q2WG76 / Ripply2
  
Possible biological names infered from orthology : Q5TAB7 / ripply transcriptional repressor 2
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: E3.1
Gene start: 87015537
Gene end: 87019917
  
Corresponding Affymetrix probe sets: 10587621 (MoGene1.0st)   1447726_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000055369
NCBI entrez gene - 382089     See in Manteia.
MGI - MGI:2685968
RefSeq - NM_001037907
RefSeq - XM_006511261
RefSeq Peptide - NP_001032996
swissprot - Q2WG76
Ensembl - ENSMUSG00000047897
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q2WG79ENSDARG00000070535Danio rerio
 RIPPLY2ENSGALG00000015845Gallus gallus
 Q5TAB7ENSG00000203877Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q2WG77 / Ripply1 / Protein ripply1 / Q0D2K3* / ripply transcriptional repressor 1*ENSMUSG0000007294534


Protein motifs (from Interpro)
Interpro ID Name
 IPR028127  Ripply family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IBA
 biological_processGO:0001503 ossification IMP
 biological_processGO:0001756 somitogenesis IDA
 biological_processGO:0007219 Notch signaling pathway IGI
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0009798 axis specification IMP
 biological_processGO:0010468 regulation of gene expression IGI
 biological_processGO:0032525 somite rostral/caudal axis specification IDA
 biological_processGO:0036342 post-anal tail morphogenesis IMP
 biological_processGO:0060349 bone morphogenesis IGI
 cellular_componentGO:0005634 nucleus IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Prkntm1Ccs/Prkntm1Ccs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ripply1tm1.1Sjt/Ripply1tm1.1Sjt,Ripply2tm1.1Ysa/Ripply2tm1.1Ysa
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA * FVB/N

Allelic Composition: Ripply1tm1.1Sjt/Y,Ripply2tm1.1Ysa/Ripply2tm1.1Ysa
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA * FVB/N

Allelic Composition: Ripply2tm1.1Ysa/Ripply2tm1.1Ysa
Genetic Background: involves: C57BL/6 * CBA

 MP:0000140 absent pedicles "loss of part of the posteriorlateral vertebral arch of a thoracic vertebrae" [J:62022, J:62023]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Ripply2tm1.1Ysa/Ripply2tm1.1Ysa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA * ICR

Allelic Composition: Ripply1tm1.1Sjt/Ripply1tm1.1Sjt,Ripply2tm1.1Ysa/Ripply2tm1.1Ysa
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA * FVB/N

Allelic Composition: Ripply1tm1.1Sjt/Y,Ripply2tm1.1Ysa/Ripply2tm1.1Ysa
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA * FVB/N

 MP:0000152 absent proximal rib "missing part of rib structures near the spine, ribs do not contact vertebrae" [J:62022, J:62023]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc

 MP:0000153 rib bifurcation "forking or division of ribs, may be a result of partial rib fusions" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ripply2tm1Asas/Ripply2tm1Asas
Genetic Background: involves: C57BL/6 * CBA

 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
Show

Allelic Composition: Ripply2tm1Asas/Ripply2tm1Asas
Genetic Background: involves: C57BL/6 * CBA

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc

Allelic Composition: Ripply2tm1Asas/Ripply2tm1Asas
Genetic Background: involves: C57BL/6 * CBA

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc

 MP:0001689 incomplete somite formation "arrest of differentiation or patterning of the somites" [J:62882]
Show

Allelic Composition: Ripply2tm1Asas/Ripply2tm1Asas
Genetic Background: involves: C57BL/6 * CBA

 MP:0001690 failure of somite differentiation "disorganized or absent somite tissue or somite pattern in development" [J:25248]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Prkntm1Ccs/Prkntm1Ccs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Ripply2tm1Asas/Ripply2tm1Asas
Genetic Background: involves: C57BL/6 * CBA

 MP:0003939 abnormal myotome morphology "structural anomaly in the mesoderm that is derived from the somite that is fated to beome the musculature" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc

 MP:0004073 caudal body truncation "caudal part of body truncated with anterior portion relatively normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ripply2tm1Asas/Ripply2tm1Asas
Genetic Background: involves: C57BL/6 * CBA

 MP:0004604 abnormal vertebral pedicle morphology "any structural anomaly of the two short, thick processes, which project backward, one on either side, from the upper part of the body to the laminae" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ripply2tm1Asas/Ripply2tm1Asas
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Ripply2tm1.1Ysa/Ripply2tm1.1Ysa
Genetic Background: involves: C57BL/6 * CBA

 MP:0004734 small thoracic cavity "reduced size of the cavity in the vertebrate body enclosed by the ribcage between the diaphragm and the neck, and contains the lungs, heart, thoracic aorta, pulmonary artery and its branches, thymus gland, and the respiratory airway" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ripply2tm1Asas/Ripply2tm1Asas
Genetic Background: involves: C57BL/6 * CBA

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Ripply2tm1.1Ysa/Ripply2tm1.1Ysa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA * ICR

 MP:0008530 abnormal rostral-caudal patterning of the somites "anomaly in the developmental pattern of the somites along the axis that runs from the head to the caudal region of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ripply2tm1Asas/Ripply2tm1Asas
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Ripply1tm1.1Sjt/Ripply1tm1.1Sjt,Ripply2tm1.1Ysa/Ripply2tm1.1Ysa
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA * FVB/N

Allelic Composition: Ripply1tm1.1Sjt/Y,Ripply2tm1.1Ysa/Ripply2tm1.1Ysa
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA * FVB/N

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: B6.129P2-Apoetm1Unc

Allelic Composition: Ripply2tm1Asas/Ripply2tm1Asas
Genetic Background: involves: C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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