ENSMUSG00000048078


Mus musculus

Features
Gene ID: ENSMUSG00000048078
  
Biological name :Tenm4
  
Synonyms : Q3UHK6 / Teneurin-4 / Tenm4
  
Possible biological names infered from orthology : Q6N022 / teneurin transmembrane protein 4
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: E1
Gene start: 96171246
Gene end: 96911093
  
Corresponding Affymetrix probe sets: 10554969 (MoGene1.0st)   10555007 (MoGene1.0st)   1434530_at (Mouse Genome 430 2.0 Array)   1451888_a_at (Mouse Genome 430 2.0 Array)   1455993_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120529
Ensembl peptide - ENSMUSP00000114281
Ensembl peptide - ENSMUSP00000145766
Ensembl peptide - ENSMUSP00000102780
Ensembl peptide - ENSMUSP00000102783
Ensembl peptide - ENSMUSP00000102784
NCBI entrez gene - 23966     See in Manteia.
MGI - MGI:2447063
RefSeq - XM_017322229
RefSeq - XM_011241787
RefSeq - XM_011241788
RefSeq - XM_011241789
RefSeq - XM_011241790
RefSeq - XM_011241792
RefSeq - XM_011241793
RefSeq - XM_017322228
RefSeq - NM_001310760
RefSeq - NM_001310762
RefSeq - NM_011858
RefSeq - XM_006507801
RefSeq - XM_006507803
RefSeq - XM_006507804
RefSeq - XM_006507805
RefSeq - XM_006507806
RefSeq - XM_006507807
RefSeq - XM_006507808
RefSeq - XM_006507812
RefSeq Peptide - NP_035988
RefSeq Peptide - NP_001297689
RefSeq Peptide - NP_001297691
swissprot - A0A0U1RNZ7
swissprot - Q3UHK6
swissprot - D3YVP2
swissprot - F6UP10
Ensembl - ENSMUSG00000048078
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tenm4ENSDARG00000105088Danio rerio
 TENM4ENSG00000149256Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tenm3 / teneurin transmembrane protein 3 / Q9P273*ENSMUSG0000003156166
Tenm2 / teneurin-2 isoform 2 / Q9NT68* / teneurin transmembrane protein 2*ENSMUSG0000004933663
Tenm1 / Q9WTS4 / teneurin transmembrane protein 1 / Q9UKZ4*ENSMUSG0000001615062
Wif1 / Q9WUA1 / Wnt inhibitory factor 1 / Q9Y5W5*ENSMUSG000000202183
Vwde / Q6DFV8 / von Willebrand factor D and EGF domains / Q8N2E2*ENSMUSG000000796793


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR006530  YD repeat
 IPR008969  Carboxypeptidase-like, regulatory domain superfamily
 IPR009471  Teneurin intracellular, N-terminal
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR011048  Cytochrome cd1-nitrite reductase-like, haem d1 domain superfamily
 IPR013032  EGF-like, conserved site
 IPR013111  EGF-like domain, extracellular
 IPR022385  Rhs repeat-associated core
 IPR027688  Teneurin-1/4
 IPR028916  Tox-GHH domain
 IPR031325  RHS repeat


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis IBA
 biological_processGO:0001702 gastrulation with mouth forming second IMP
 biological_processGO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031641 regulation of myelination IEA
 biological_processGO:0031643 positive regulation of myelination IMP
 biological_processGO:0032289 central nervous system myelin formation IEA
 biological_processGO:0048666 neuron development IEA
 biological_processGO:0048714 positive regulation of oligodendrocyte differentiation IMP
 biological_processGO:0060038 cardiac muscle cell proliferation IMP
 biological_processGO:0060912 cardiac cell fate specification IMP
 biological_processGO:0097264 self proteolysis IEA
 biological_processGO:2000543 positive regulation of gastrulation IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IDA
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0046982 protein heterodimerization activity IBA
 molecular_functionGO:0050839 cell adhesion molecule binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tenm4Tg(Col2a1-Hspg2)2Yoya/Tenm4Tg(Col2a1-Hspg2)2Yoya
Genetic Background: C57BL/6-Tenm4Tg(Col2a1-Hspg2)2Yoya

 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tenm4Tg(Col2a1-Hspg2)2Yoya/Tenm4Tg(Col2a1-Hspg2)2Yoya
Genetic Background: C57BL/6-Tenm4Tg(Col2a1-Hspg2)2Yoya

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tenm4Tg(Col2a1-Hspg2)2Yoya/Tenm4Tg(Col2a1-Hspg2)2Yoya
Genetic Background: C57BL/6-Tenm4Tg(Col2a1-Hspg2)2Yoya

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Tenm4l7Rn3-1R/Tenm4l7Rn3-1R
Genetic Background: FRCH.Cg-Tenm4l7Rn3-2R

 MP:0000953 abnormal oligodendrocyte morphology "anomalous structure, number or composition of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tenm4Tg(Col2a1-Hspg2)2Yoya/Tenm4Tg(Col2a1-Hspg2)2Yoya
Genetic Background: C57BL/6-Tenm4Tg(Col2a1-Hspg2)2Yoya

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Tenm4Tg(Col2a1-Hspg2)2Yoya/Tenm4Tg(Col2a1-Hspg2)2Yoya
Genetic Background: C57BL/6-Tenm4Tg(Col2a1-Hspg2)2Yoya

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Tenm4l7Rn3-3R/Tenm4l7Rn3-3R
Genetic Background: involves: BALB/cRl * C3H/Rl * C57BL/10Rl

Allelic Composition: Tenm4l7Rn3-4R/Tyrc-26DVT
Genetic Background: involves: 101/Rl * BALB/cRl * C3H/Rl * C57BL/10Rl * T-stock

Allelic Composition: Tenm4Tg(Col2a1-Hspg2)2Yoya/Tenm4Tg(Col2a1-Hspg2)2Yoya
Genetic Background: C57BL/6-Tenm4Tg(Col2a1-Hspg2)2Yoya

 MP:0001622 abnormal vasculogenesis "aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tenm4l7Rn3-4R/Tyrc-26DVT
Genetic Background: involves: 101/Rl * BALB/cRl * C3H/Rl * C57BL/10Rl * T-stock

 MP:0001683 absent mesoderm "missing or failure to differentiate the middle primary germ layer " [J:40594]
Show

Allelic Composition: Lama2dy-2J/Lama2dy-2J,Lama4tm1Ktry/Lama4tm1Ktry,Tg(ACTB-Lama5)1Jhm/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * WK/ReJ

Allelic Composition: Tenm4l7Rn3-1R/Tenm4l7Rn3-1R
Genetic Background: FRCH.Cg-Tenm4l7Rn3-2R

 MP:0001689 incomplete somite formation "arrest of differentiation or patterning of the somites" [J:62882]
Show

Allelic Composition: Tenm4l7Rn3-1R/Tenm4l7Rn3-1R
Genetic Background: FRCH.Cg-Tenm4l7Rn3-2R

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Lama2dy-2J/Lama2dy-2J,Lama4tm1Ktry/Lama4tm1Ktry,Tg(ACTB-Lama5)1Jhm/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * WK/ReJ

Allelic Composition: Tenm4l7Rn3-1R/Tenm4l7Rn3-1R
Genetic Background: FRCH.Cg-Tenm4l7Rn3-2R

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tenm4l7Rn3-4R/Tyrc-26DVT
Genetic Background: involves: 101/Rl * BALB/cRl * C3H/Rl * C57BL/10Rl * T-stock

 MP:0003400 kinked neural tube "twists or kinks in the embryonic neural tube" [J:66514, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tenm4l7Rn3-4R/Tyrc-26DVT
Genetic Background: involves: 101/Rl * BALB/cRl * C3H/Rl * C57BL/10Rl * T-stock

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tenm4l7Rn3-1R/Tenm4l7Rn3-1R
Genetic Background: FRCH.Cg-Tenm4l7Rn3-2R

Allelic Composition: Tenm4l7Rn3-4R/Tyrc-26DVT
Genetic Background: involves: 101/Rl * BALB/cRl * C3H/Rl * C57BL/10Rl * T-stock

Allelic Composition: Tenm4l7Rn3-5R/Tenm4l7Rn3-5R
Genetic Background: FRCH.Cg-Odz4l7Rn3-5R

Allelic Composition: Tenm4l7Rn3-6R/Tenm4l7Rn3-6R
Genetic Background: FRCH.Cg-Odz4l7Rn3-6R

 MP:0004608 abnormal cervical axis morphology "any structural anomaly of the second cervical vertebra (C2) which forms the pivot upon which the first cervical (atlas, C1) vertebra rotates" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tenm4l7Rn3-4R/Tyrc-26DVT
Genetic Background: involves: 101/Rl * BALB/cRl * C3H/Rl * C57BL/10Rl * T-stock

Allelic Composition: Tenm4l7Rn3-3R/Tenm4l7Rn3-6R
Genetic Background: Not Specified

 MP:0004621 lumbar vertebral fusion "the union of one or more lumbar vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tenm4l7Rn3-4R/Tyrc-26DVT
Genetic Background: involves: 101/Rl * BALB/cRl * C3H/Rl * C57BL/10Rl * T-stock

 MP:0004623 thoracic vertebral fusion "the union of one or more thoracic vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tenm4l7Rn3-4R/Tyrc-26DVT
Genetic Background: involves: 101/Rl * BALB/cRl * C3H/Rl * C57BL/10Rl * T-stock

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lama2dy-2J/Lama2dy-2J,Lama4tm1Ktry/Lama4tm1Ktry,Tg(ACTB-Lama5)1Jhm/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * WK/ReJ

Allelic Composition: Tenm4l7Rn3-1R/Tenm4l7Rn3-1R
Genetic Background: FRCH.Cg-Tenm4l7Rn3-2R

 MP:0005650 abnormal limb bud morphology "aberrant structure or development of any of the swellings on the trunk of the embryo that become limbs" [hdene:Howard Dene , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:61460]
Show

Allelic Composition: Tenm4l7Rn3-4R/Tyrc-26DVT
Genetic Background: involves: 101/Rl * BALB/cRl * C3H/Rl * C57BL/10Rl * T-stock

 MP:0008027 abnormal spinal cord white matter morphology "any structural anomaly of the regions of the spinal cord that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tenm4Tg(Col2a1-Hspg2)2Yoya/Tenm4Tg(Col2a1-Hspg2)2Yoya
Genetic Background: C57BL/6-Tenm4Tg(Col2a1-Hspg2)2Yoya

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tenm4l7Rn3-5R/Tenm4l7Rn3-5R
Genetic Background: FRCH.Cg-Odz4l7Rn3-5R

Allelic Composition: Tenm4l7Rn3-6R/Tenm4l7Rn3-6R
Genetic Background: FRCH.Cg-Odz4l7Rn3-6R

 MP:0009677 abnormal spinal cord dorsal column morphology "any structural anomaly of the wedge-shaped fiber bundle of white matter in the dorsomedial side of the spinal cord that is made up of the fasciculus gracilis and fasciculus cuneatus; it is part of the ascending posterior column-medial lemniscus pathway that is important for well-localized fine touch and conscious proprioception" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN-10:0940780577 "Goldberg, S, Clinical Neuroanatomy Made Ridiculously Simple, 3rd edition"]
Show

Allelic Composition: Tenm4Tg(Col2a1-Hspg2)2Yoya/Tenm4Tg(Col2a1-Hspg2)2Yoya
Genetic Background: C57BL/6-Tenm4Tg(Col2a1-Hspg2)2Yoya

 MP:0010205 abnormal oligodendrocyte apoptosis "change in the timing or the number of oligodendrocytes undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tenm4Tg(Col2a1-Hspg2)2Yoya/Tenm4Tg(Col2a1-Hspg2)2Yoya
Genetic Background: C57BL/6-Tenm4Tg(Col2a1-Hspg2)2Yoya

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Nell1l7R6-3R/Nell1l7R6-3R
Genetic Background: involves: BJR

Allelic Composition: Tenm4l7Rn3-2R/Tenm4l7Rn3-2R
Genetic Background: involves: BALB/cRl * C3H/Rl * C57BL/10Rl

Allelic Composition: Tenm4l7Rn3-3R/Tenm4l7Rn3-3R
Genetic Background: involves: BALB/cRl * C3H/Rl * C57BL/10Rl

Allelic Composition: Tenm4l7Rn3-5R/Tenm4l7Rn3-5R
Genetic Background: involves: BALB/cRl * C3H/Rl * C57BL/10Rl

Allelic Composition: Tenm4l7Rn3-6R/Tenm4l7Rn3-6R
Genetic Background: involves: BALB/cRl * C3H/Rl * C57BL/10Rl

Allelic Composition: Tenm4l7Rn3-4R/Tyrc-26DVT
Genetic Background: involves: 101/Rl * BALB/cRl * C3H/Rl * C57BL/10Rl * T-stock

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Lama2dy-2J/Lama2dy-2J,Lama4tm1Ktry/Lama4tm1Ktry,Tg(ACTB-Lama5)1Jhm/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * WK/ReJ

Allelic Composition: Tenm4l7Rn3-1R/Tenm4l7Rn3-1R
Genetic Background: FRCH.Cg-Tenm4l7Rn3-2R

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Tenm4l7Rn3-1R/Tenm4l7Rn3-1R
Genetic Background: FRCH.Cg-Tenm4l7Rn3-2R

Allelic Composition: Tenm4l7Rn3-5R/Tenm4l7Rn3-5R
Genetic Background: FRCH.Cg-Odz4l7Rn3-5R

Allelic Composition: Tenm4l7Rn3-6R/Tenm4l7Rn3-6R
Genetic Background: FRCH.Cg-Odz4l7Rn3-6R

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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