Manteia - Molecule gene

ENSMUSG00000048616

Mus musculus

Features

Gene ID:	ENSMUSG00000048616

Biological name :	Nog

Synonyms :	Nog / Noggin / P97466

Possible biological names infered from orthology :	Q13253

Species:	Mus musculus

Chr. number:	11
Strand:	-1
Band:	C
Gene start:	89300638
Gene end:	89302332

Corresponding Affymetrix probe sets:	10389752 (MoGene1.0st) 1422300_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000061427 NCBI entrez gene - 18121 See in Manteia. MGI - MGI:104327 RefSeq - NM_008711 RefSeq Peptide - NP_032737 swissprot - A2RTJ4 swissprot - P97466 Ensembl - ENSMUSG00000048616

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
nog1	ENSDARG00000058819	Danio rerio
nog3	ENSDARG00000053528	Danio rerio
NOG	ENSGALG00000003114	Gallus gallus
NOG	ENSG00000183691	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR008717	Noggin
IPR029034	Cystine-knot cytokine

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP
biological_process	GO:0001501	skeletal system development	IMP
biological_process	GO:0001649	osteoblast differentiation	IMP
biological_process	GO:0001655	urogenital system development	IMP
biological_process	GO:0001657	ureteric bud development	IDA
biological_process	GO:0001701	in utero embryonic development	IMP
biological_process	GO:0001706	endoderm formation	IDA
biological_process	GO:0001707	mesoderm formation	IDA
biological_process	GO:0001837	epithelial to mesenchymal transition	IMP
biological_process	GO:0001839	neural plate morphogenesis	IMP
biological_process	GO:0001843	neural tube closure	IMP
biological_process	GO:0003149	membranous septum morphogenesis	IMP
biological_process	GO:0003151	outflow tract morphogenesis	IMP
biological_process	GO:0003203	endocardial cushion morphogenesis	IMP
biological_process	GO:0003223	ventricular compact myocardium morphogenesis	IMP
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0007389	pattern specification process	IMP
biological_process	GO:0007411	axon guidance	IMP
biological_process	GO:0007417	central nervous system development	IMP
biological_process	GO:0007420	brain development	IMP
biological_process	GO:0007492	endoderm development	IDA
biological_process	GO:0008045	motor neuron axon guidance	IMP
biological_process	GO:0009953	dorsal/ventral pattern formation	ISO
biological_process	GO:0010628	positive regulation of gene expression	IMP
biological_process	GO:0010629	negative regulation of gene expression	IDA
biological_process	GO:0021510	spinal cord development	IMP
biological_process	GO:0021533	cell differentiation in hindbrain	ISO
biological_process	GO:0021915	neural tube development	IMP
biological_process	GO:0021983	pituitary gland development	IMP
biological_process	GO:0030154	cell differentiation	IEA
biological_process	GO:0030336	negative regulation of cell migration	IEA
biological_process	GO:0030509	BMP signaling pathway	IDA
biological_process	GO:0030510	regulation of BMP signaling pathway	IMP
biological_process	GO:0030514	negative regulation of BMP signaling pathway	ISO
biological_process	GO:0035019	somatic stem cell population maintenance	IEA
biological_process	GO:0042060	wound healing	IMP
biological_process	GO:0042474	middle ear morphogenesis	ISO
biological_process	GO:0042733	embryonic digit morphogenesis	ISO
biological_process	GO:0045596	negative regulation of cell differentiation	IEA
biological_process	GO:0045668	negative regulation of osteoblast differentiation	ISO
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI
biological_process	GO:0048318	axial mesoderm development	IMP
biological_process	GO:0048570	notochord morphogenesis	IMP
biological_process	GO:0048646	anatomical structure formation involved in morphogenesis	IMP
biological_process	GO:0048706	embryonic skeletal system development	IEA
biological_process	GO:0048712	negative regulation of astrocyte differentiation	IMP
biological_process	GO:0048762	mesenchymal cell differentiation	IMP
biological_process	GO:0050679	positive regulation of epithelial cell proliferation	IMP
biological_process	GO:0051216	cartilage development	IEA
biological_process	GO:0055009	atrial cardiac muscle tissue morphogenesis	IMP
biological_process	GO:0060044	negative regulation of cardiac muscle cell proliferation	IMP
biological_process	GO:0060173	limb development	IEA
biological_process	GO:0060272	embryonic skeletal joint morphogenesis	ISO
biological_process	GO:0060302	negative regulation of cytokine activity	ISO
biological_process	GO:0060325	face morphogenesis	IMP
biological_process	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation	IMP
biological_process	GO:0060412	ventricular septum morphogenesis	IMP
biological_process	GO:0060425	lung morphogenesis	IMP
biological_process	GO:0060513	prostatic bud formation	IMP
biological_process	GO:0060676	ureteric bud formation	IDA
biological_process	GO:0060825	fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation	ISO
biological_process	GO:0061037	negative regulation of cartilage development	IDA
biological_process	GO:0061053	somite development	IMP
biological_process	GO:0061312	BMP signaling pathway involved in heart development	IMP
biological_process	GO:0061384	heart trabecula morphogenesis	IMP
biological_process	GO:0061626	pharyngeal arch artery morphogenesis	IMP
biological_process	GO:0071773	cellular response to BMP stimulus	IDA
biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IEA
biological_process	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	IDA
biological_process	GO:0090193	positive regulation of glomerulus development	IDA
biological_process	GO:1905006	negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation	IMP
biological_process	GO:2000313	regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation	ISO
biological_process	GO:2001234	negative regulation of apoptotic signaling pathway	IMP
cellular_component	GO:0005576	extracellular region	IEA
cellular_component	GO:0005615	extracellular space	IEA
molecular_function	GO:0019955	cytokine binding	ISO
molecular_function	GO:0042803	protein homodimerization activity	IEA

Pathways (from Reactome)

Pathway description

Signaling by BMP

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000029	abnormal malleus morphology	"structural anomaly in the largest of the three auditory ossicles, which resembles a club or hammer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: L1cam^tm1Mtei/Y Genetic Background: either: (involves: 129/Sv * C57BL/6J) or (involves: 129/Sv * 129S/SvEv)
MP:0000031	abnormal cochlea morphology	"any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]	Show Allelic Composition: Trp53^tm1Brd/Trp53^tm1Brd,Tg(Lck-cre)1Cwi/0 Genetic Background: involves: 129S7/SvEvBrd
MP:0000049	abnormal middle ear morphology	"malformation or malfunction of any components of the tympanic cavity or its ossicles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: L1cam^tm1Mtei/Y Genetic Background: either: (involves: 129/Sv * C57BL/6J) or (involves: 129/Sv * 129S/SvEv)
MP:0000077	abnormal interparietal bone morphology	"malformed bone of the cranium; lies above and anterior to the occipital bone " [J:61509]	Show Allelic Composition: Cer1^tm1Belo/Cer1^tm1Belo,Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv
MP:0000087	absent mandible	"missing the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cdkn2d^tm1Maro/Cdkn2d^tm1Maro Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0000107	abnormal frontal bone morphology	"malformed bone forming the forehead and part of the eye orbit" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]	Show Allelic Composition: Cer1^tm1Belo/Cer1^tm1Belo,Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv
MP:0000109	abnormal parietal bone morphology	"malformed curved bone forming part of the vault of the cranium" [J:17489]	Show Allelic Composition: Cer1^tm1Belo/Cer1^tm1Belo,Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv
MP:0000137	abnormal vertebrae morphology	"malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Nog^tm1.1Rmh/Nog^tm1.1Rmh,Tmem163^{Tg(ACTB-cre)2Mrt}/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL
MP:0000150	abnormal rib morphology	"malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]	Show Allelic Composition: L1cam^tm1Mtei/Y Genetic Background: either: (involves: 129/Sv * C57BL/6J) or (involves: 129/Sv * 129S/SvEv) Allelic Composition: Nog^tm1Amc/Nog⁺ Genetic Background: B6.129S1-Nog^tm1Amc Allelic Composition: Nog^tm1Amc/Nog⁺ Genetic Background: involves: 129S1/Sv * CD-1 Allelic Composition: Nog^tm1.1Rmh/Nog^tm1.1Rmh,Tmem163^{Tg(ACTB-cre)2Mrt}/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL
MP:0000160	kyphosis	"forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Nog^tm1Amc/Nog⁺ Genetic Background: involves: 129S1/Sv * CD-1
MP:0000163	abnormal cartilage morphology	"anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Srgap3^tm1.1Ssod/Srgap3⁺,Tg(Thy1-EGFP)#Jrs/0 Genetic Background: involves: C57BL/6J * CBA
MP:0000164	abnormal cartilage development	"anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Srgap3^tm1.1Ssod/Srgap3⁺,Tg(Thy1-EGFP)#Jrs/0 Genetic Background: involves: C57BL/6J * CBA
MP:0000428	abnormal craniofacial morphology	"anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Pde6b^rd1/Pde6b^rgsc1754 Genetic Background: involves: C3H * C57BL/6JJcl
MP:0000432	abnormal head morphology	"anomalous structure or development of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Tyr^c-46H/Tyr^c-46H Genetic Background: Not Specified
MP:0000474	abnormal foregut morphology	"malformed cephalic portion of the primitive digestive tube of the embryo" [J:35802]	Show Allelic Composition: Kitl^Sl-3Neu/Kitl⁺ Genetic Background: involves: 102/El * C3H/El
MP:0000537	abnormal urethra morphology	"anomalous structure of the canal leading from the bladder, discharging the urine externally" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Postn^tm1Jmol/Postn^tm1Jmol Genetic Background: involves: 129/Sv * C57BL/6
MP:0000547	short limbs	"reduced average length of the extremities" [MGI:CLS, J:61509]	Show Allelic Composition: Disp1^tm1Pab/Disp1^tm1Pab Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Cer1^tm1Belo/Cer1^tm1Belo,Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv
MP:0000585	kinked tail	"a sharp bend or zig-zag in the tail" [J:61295]	Show Allelic Composition: L1cam^tm1Mtei/Y Genetic Background: either: (involves: 129/Sv * C57BL/6J) or (involves: 129/Sv * 129S/SvEv) Allelic Composition: Nog^tm1Amc/Nog⁺ Genetic Background: B6.129S1-Nog^tm1Amc Allelic Composition: Nog^tm1Amc/Nog⁺ Genetic Background: involves: 129S1/Sv * CD-1
MP:0000661	small ventral prostate	"reduced size of lateral lobe of the prostate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63764]	Show Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv * C57BL/6J * ICR
MP:0000787	abnormal telencephalon morphology	"any malformation or absence of the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Cdkn2d^tm1Maro/Cdkn2d^tm1Maro Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0000830	abnormal diencephalon morphology	"any malformation or absence of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Cdkn2d^tm1Maro/Cdkn2d^tm1Maro Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: either: (involves: 129S1/Sv * CD-1) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0000913	abnormal brain development	"malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]	Show Allelic Composition: Nog^tm1.1Rmh/Nog^tm1.1Rmh,Tmem163^{Tg(ACTB-cre)2Mrt}/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL
MP:0000914	exencephaly	"neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: L1cam^tm1Mtei/Y Genetic Background: either: (involves: 129/Sv * C57BL/6J) or (involves: 129/Sv * 129S/SvEv) Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv * CD-1 Allelic Composition: Cer1^tm1Belo/Cer1^tm1Belo,Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: C57BL/6
MP:0000928	incomplete cephalic closure	"arrest of the fusion of the cephalic neural folds" [J:12622]	Show Allelic Composition: Disp1^tm1Pab/Disp1^tm1Pab Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * CD-1 * ICR)
MP:0000929	open neural tube	"incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]	Show Allelic Composition: Cer1^tm1Belo/Cer1^tm1Belo,Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * CD-1 * ICR) Allelic Composition: Grem1^tm1Ecan/Grem1^tm1Ecan,Nog^tm1.1Rmh/Nog^tm1.1Rmh,Tmem163^{Tg(ACTB-cre)2Mrt}/0 Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N * SJL Allelic Composition: Grem1^tm1Ecan/Grem1⁺,Nog^tm1.1Rmh/Nog^tm1.1Rmh,Tmem163^{Tg(ACTB-cre)2Mrt}/0 Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N * SJL
MP:0000930	wavy neural tube	"undulations in the embryonic neural tube" [J:37888]	Show Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv
MP:0000932	absent notochord	"missing axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]	Show Allelic Composition: Cdkn2d^tm1Maro/Cdkn2d^tm1Maro Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0000955	abnormal spinal cord morphology	"malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Disp1^tm1Pab/Disp1^tm1Pab Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv
MP:0001145	abnormal male reproductive anatomy	"anomalous structure of the organs associated with producing offspring in the gender that produces spermatozoa" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Postn^tm1Jmol/Postn^tm1Jmol Genetic Background: involves: 129/Sv * C57BL/6
MP:0001158	abnormal prostate morphology	"mallformed gland in males that secretes part of the seminiferous fluid" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:63764]	Show Allelic Composition: Postn^tm1Jmol/Postn^tm1Jmol Genetic Background: involves: 129/Sv * C57BL/6
MP:0001175	abnormal lung morphology	"malformed organ of respiration" [J:35802]	Show Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv
MP:0001176	abnormal lung development	"malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]	Show Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv
MP:0001286	abnormal eye development	"malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]	Show Allelic Composition: Disp1^tm1Pab/Disp1^tm1Pab Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001293	anophthalmia	"congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]	Show Allelic Composition: Cdkn2d^tm1Maro/Cdkn2d^tm1Maro Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0001688	abnormal somite development	"anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Disp1^tm1Pab/Disp1^tm1Pab Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv Allelic Composition: Grem1^tm1Ecan/Grem1^tm1Ecan,Nog^tm1.1Rmh/Nog^tm1.1Rmh,Tmem163^{Tg(ACTB-cre)2Mrt}/0 Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N * SJL
MP:0001698	reduced embryo size	"smaller proportions of embryo compared to littermates" [J:61790]	Show Allelic Composition: Disp1^tm1Pab/Disp1^tm1Pab Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001706	abnormal left-right axis patterning	"anomaly in the formation or development of the body or a specific organ of the body in relation to the left and right sides of the body or organ" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cdkn2d^tm1Maro/Cdkn2d^tm1Maro Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0001785	edema	"an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]	Show Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv * CD-1
MP:0002080	prenatal lethality	"death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Nrg1^tm1Cbm/Nrg1^tm3Cbm,Isl2^tm1Arbr/Isl2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
MP:0002081	perinatal lethality	"death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: L1cam^tm1Mtei/Y Genetic Background: either: (involves: 129/Sv * C57BL/6J) or (involves: 129/Sv * 129S/SvEv) Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv * CD-1
MP:0002085	abnormal embryonic tissue morphology	"structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Chrd^tm1Emdr/Chrd^tm1Emdr,Nodal^tm1Rob/Nodal⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ Allelic Composition: Nog^tm1Amc/Nog⁺,Smad3^tm1Xfw/Smad3⁺ Genetic Background: involves: 129/Sv * 129S1/Sv Allelic Composition: Nog^tm1Amc/Nog⁺,Smad3^tm1Xfw/Smad3^tm1Xfw Genetic Background: involves: 129/Sv * 129S1/Sv Allelic Composition: Nog^tm1Amc/Nog^tm1Amc,Smad3^tm1Xfw/Smad3^tm1Xfw Genetic Background: involves: 129/Sv * 129S1/Sv
MP:0002108	abnormal muscle morphology	"abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Nog^tm1Amc/Nog⁺ Genetic Background: B6.129S1-Nog^tm1Amc
MP:0002109	abnormal limb morphology	"abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Nog^tm1Amc/Nog⁺ Genetic Background: B6.129S1-Nog^tm1Amc
MP:0002113	abnormal skeleton development	"anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Srgap3^tm1.1Ssod/Srgap3⁺,Tg(Thy1-EGFP)#Jrs/0 Genetic Background: involves: C57BL/6J * CBA
MP:0002114	abnormal axial skeleton morphology	"abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Disp1^tm1Pab/Disp1^tm1Pab Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Nog^tm1Amc/Nog⁺ Genetic Background: involves: 129S1/Sv * CD-1 Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv
MP:0002151	abnormal neural tube morphology/development	"anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Disp1^tm1Pab/Disp1^tm1Pab Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: C57BL/6 Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * CD-1 * ICR) Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: either: (involves: 129S1/Sv * CD-1) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) Allelic Composition: Grem1^tm1Ecan/Grem1⁺,Nog^tm1.1Rmh/Nog^tm1.1Rmh,Tmem163^{Tg(ACTB-cre)2Mrt}/0 Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N * SJL
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Bmp4^tm2Blh/Bmp4⁺,Nog^tm1Amc/Nog⁺ Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac
MP:0002230	abnormal primitive streak formation	"anomaly in the establishment of the midline ridge of embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Chrd^tm1Emdr/Chrd^tm1Emdr,Nodal^tm1Rob/Nodal⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ
MP:0002286	cryptorchism	"failure of one or both of the testes to descend into the scrotum around the time of birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Postn^tm1Jmol/Postn^tm1Jmol Genetic Background: involves: 129/Sv * C57BL/6
MP:0002632	vestigial tail	"a trace or rudimentary tail structure; the degenerated remains of any tail structure" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Disp1^tm1Pab/Disp1^tm1Pab Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv * CD-1
MP:0002770	absent bulbourethral gland	"missing gland in males that lie along the prostate gland that secrete a fluid component of the seminal fluid into the urethra" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:78062]	Show Allelic Composition: Postn^tm1Jmol/Postn^tm1Jmol Genetic Background: involves: 129/Sv * C57BL/6
MP:0002825	abnormal notochord	"malformation or absence of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Disp1^tm1Pab/Disp1^tm1Pab Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * CD-1 * ICR)
MP:0002896	abnormal bone mineralization	"defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv * CD-1
MP:0003125	abnormal septation of the cloaca	"absence of or reduction in the separation of the single opening of the digestive, urinary, and reproductive tracts (cloaca) into mutliple isolated openings during development, may result in hypospadia, reduced anogenital distance, or persistent cloaca" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91491]	Show Allelic Composition: Postn^tm1Jmol/Postn^tm1Jmol Genetic Background: involves: 129/Sv * C57BL/6
MP:0003130	anal atresia	"absence of a connection between the anal pit and the rectum" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91491]	Show Allelic Composition: Postn^tm1Jmol/Postn^tm1Jmol Genetic Background: involves: 129/Sv * C57BL/6
MP:0003148	reduced cochlear coiling	"a reduction in cochlear coiling or number of turns; in wild-type mice, the cochlea most commonly exhibits one and three-fourth turns" [J:56294, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Trp53^tm1Brd/Trp53^tm1Brd,Tg(Lck-cre)1Cwi/0 Genetic Background: involves: 129S7/SvEvBrd
MP:0003160	abnormal esophageal development	"aberrant formation of the part of the digestive canal through which food passes from the pharynx to the stomach" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * CD-1 * ICR)
MP:0003190	fused synovial joints	"partial or complete absence of separations containing synovial fluid between bones" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93028]	Show Allelic Composition: L1cam^tm1Mtei/Y Genetic Background: either: (involves: 129/Sv * C57BL/6J) or (involves: 129/Sv * 129S/SvEv) Allelic Composition: Nog^tm1Amc/Nog⁺ Genetic Background: B6.129S1-Nog^tm1Amc Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv * CD-1 Allelic Composition: Nog^tm1Amc/Nog⁺ Genetic Background: involves: 129S1/Sv * CD-1
MP:0003232	abnormal forebrain development	"anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Cdkn2d^tm1Maro/Cdkn2d^tm1Maro Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0003276	esophageal atresia	"congenital blockage or absence of the lumen of the esophagus" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * CD-1 * ICR)
MP:0003321	tracheoesophageal fistula	"an abnormal passage between the esophagus and the trachea, acquired or congenital, often associated with esophageal atresia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Cdkn2d^tm1Maro/Cdkn2d^tm1Maro Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * CD-1 * ICR)
MP:0003400	kinked neural tube	"twists or kinks in the embryonic neural tube" [J:66514, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv Allelic Composition: Grem1^tm1Ecan/Grem1^tm1Ecan,Nog^tm1.1Rmh/Nog^tm1.1Rmh,Tmem163^{Tg(ACTB-cre)2Mrt}/0 Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N * SJL
MP:0003456	absent tail	"completely lacking the appendage at the caudal end of the vertebral column " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cer1^tm1Belo/Cer1^tm1Belo,Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv * C57BL/6J * ICR
MP:0003704	abnormal hair follicle development	"anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Disp1^tm1Pab/Disp1^tm1Pab Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv * CD-1
MP:0003720	abnormal neural tube closure	"abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]	Show Allelic Composition: Cer1^tm1Belo/Cer1^tm1Belo,Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv
MP:0003740	fusion of middle ear ossicles	"union of the three small bones of the middle ear into a single structure " [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: L1cam^tm1Mtei/Y Genetic Background: either: (involves: 129/Sv * C57BL/6J) or (involves: 129/Sv * 129S/SvEv)
MP:0003743	abnormal facial morphology	"anomalous structure or development of the face" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Cdkn2d^tm1Maro/Cdkn2d^tm1Maro Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0003816	abnormal pituitary gland development	"malformation or incomplete differentiation of the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:51160]	Show Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: either: (involves: 129S1/Sv * CD-1) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0003938	abnormal ear development	"developmental anomaly of any of the structures involved in the ear or vestibular system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Disp1^tm1Pab/Disp1^tm1Pab Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0003942	abnormal urinary system development		Show Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv * C57BL/6J * ICR
MP:0004087	abnormal muscle fiber morphology	"malformed or poorly developed muscle fibers, the cylindrical multinucleated muscle cells that contract when stimulated" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv * CD-1
MP:0004200	reduced fetal size	"smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv * CD-1
MP:0004252	abnormal direction of looping morphogenesis	"deviation from the normal rightward direction of cardiac looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax6^3Neu/Pax6^3Neu Genetic Background: either: (involves: 102 * C3H) or (involves: C3H) Allelic Composition: Chrd^tm1Emdr/Chrd^tm1Emdr,Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J
MP:0004387	abnormal prechordal plate morphology	"any structural anomaly of the horseshoe-shaped thickening of the endoderm at the cranial (rostral) end of the primitive streak formed by the involution of Spemann s organizer cells which, together with the notochord, induces the formation of the neural plate from the overlying ectodermal cells and contributes mesodermal type cells to the surrounding tissue" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"]	Show Allelic Composition: Nog^tm1Amc/Nog^tm1Amc,Smad3^tm1Xfw/Smad3⁺ Genetic Background: involves: 129/Sv * 129S1/Sv
MP:0004395	increased cochlear inner hair cell number	"increased number (or more than the expected single row) of the flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Trp53^tm1Brd/Trp53^tm1Brd,Tg(Lck-cre)1Cwi/0 Genetic Background: involves: 129S7/SvEvBrd
MP:0004401	increased cochlear outer hair cell number	"increased number (or more than the expected 3 rows) of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Trp53^tm1Brd/Trp53^tm1Brd,Tg(Lck-cre)1Cwi/0 Genetic Background: involves: 129S7/SvEvBrd
MP:0004554	small pharynx	"reduced size/diameter of the passage between the mouth and the posterior nares and the larynx and esophagus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Chrd^tm1Emdr/Chrd^tm1Emdr,Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J
MP:0004575	small limb buds	"reduced size of the mesenchymal outgrowth on the lateral trunk of the embryo that develops into the limbs" [MESH:National Library of Medicine_Medical Subject Headings]	Show Allelic Composition: L1cam^tm1Mtei/Y Genetic Background: either: (involves: 129/Sv * C57BL/6J) or (involves: 129/Sv * 129S/SvEv)
MP:0004599	abnormal vertebral arch morphology	"any structural anomaly of the dorsal part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv Allelic Composition: Bmp4^tm2Blh/Bmp4⁺,Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac
MP:0004603	absent vertebral arch	"loss of the dorsal part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv
MP:0004616	lumbar vertebral transformation	"homeotic transformation of any lumbar vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nbl1^tm2Rmh/Nbl1^tm2Rmh Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac) or (involves: 129P2/OlaHsd * C57BL/6J)
MP:0004739	conductive hearing loss	"progressive hearing loss due to lesions in the external auditory canal or middle ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: L1cam^tm1Mtei/Y Genetic Background: either: (involves: 129/Sv * C57BL/6J) or (involves: 129/Sv * 129S/SvEv)
MP:0005105	abnormal middle ear ossicle morphology	"anomalous structure or development of the three small bones of the middle ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: L1cam^tm1Mtei/Y Genetic Background: either: (involves: 129/Sv * C57BL/6J) or (involves: 129/Sv * 129S/SvEv)
MP:0005106	abnormal incus morphology	"structural anomaly of the middle of the three auditory ossicles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]	Show Allelic Composition: L1cam^tm1Mtei/Y Genetic Background: either: (involves: 129/Sv * C57BL/6J) or (involves: 129/Sv * 129S/SvEv)
MP:0005107	abnormal stapes morphology	"structural anomaly of the smallest and innermost of the three auditory ossicles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]	Show Allelic Composition: L1cam^tm1Mtei/Y Genetic Background: either: (involves: 129/Sv * C57BL/6J) or (involves: 129/Sv * 129S/SvEv)
MP:0005157	holoprosencephaly	"presence of a single forebrain hemisphere or lobe; often accompanied by a deficit in median facial development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83058]	Show Allelic Composition: Cdkn2d^tm1Maro/Cdkn2d^tm1Maro Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Nog^tm1Amc/Nog^tm1Amc,Smad3^tm1Xfw/Smad3⁺ Genetic Background: involves: 129/Sv * 129S1/Sv Allelic Composition: Nog^tm1Amc/Nog⁺,Smad3^tm1Xfw/Smad3^tm1Xfw Genetic Background: involves: 129/Sv * 129S1/Sv Allelic Composition: Nog^tm1Amc/Nog^tm1Amc,Smad3^tm1Xfw/Smad3^tm1Xfw Genetic Background: involves: 129/Sv * 129S1/Sv
MP:0005163	cyclopia	"a congenital defect in which the two orbits are united to form a single cavity containing one eye" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60303]	Show Allelic Composition: Cdkn2d^tm1Maro/Cdkn2d^tm1Maro Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0005225	abnormal vertebrae development	"anomalous formation of the vertebrae from the sclerotome" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: C57BL/6
MP:0005269	abnormal occipital bone morphology	"anomalous structure of the bone at the lower, posterior part of the skull" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cer1^tm1Belo/Cer1^tm1Belo,Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv
MP:0005297	spina bifida occulta	"common congenital midline defect of fusion of the vertebral arch without protrusion of the spinal cord or meninges" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv
MP:0005315	absent pituitary gland	"missing gland that is normally suspended from the base of the hypothalamus and which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:30559]	Show Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: either: (involves: 129S1/Sv * CD-1) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0005508	abnormal skeleton morphology	"malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: C57BL/6
MP:0005646	abnormal pituitary gland physiology	"anmalous function of this unpaired compound gland suspended from the base of the hypothalamus by a short extension of the infundibulum, the infundibular or pituitary stalk" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: either: (involves: 129S1/Sv * CD-1) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0005650	abnormal limb bud morphology	"aberrant structure or development of any of the swellings on the trunk of the embryo that become limbs" [hdene:Howard Dene , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:61460]	Show Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv * CD-1
MP:0005657	abnormal neural plate morphology	"malformation or absence of the neuroectodermal area of the embryo s dorsal surface that develops into the neural tube and neural crest" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator, J:68142]	Show Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv
MP:0006042	increased apoptosis	"greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv
MP:0006281	abnormal tail development	"anomaly in the formation of the tail" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Grem1^tm1Ecan/Grem1^tm1Ecan,Nog^tm1.1Rmh/Nog^tm1.1Rmh,Tmem163^{Tg(ACTB-cre)2Mrt}/0 Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N * SJL
MP:0006290	proboscis	"a long, cylindric protuberance of the face that, in cyclopia or ethmocephaly, represents the nose" [J:92058, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Chrd^tm1Emdr/Chrd^tm1Emdr,Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J
MP:0006291	aprosencephaly	"the most severe form of holoprosencephaly where the entire prosencephalon (both telencephalon and diencephalon) fails to develop while the hindbrain is largely preserved" [J:60303, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Chrd^tm1Emdr/Chrd^tm1Emdr,Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J
MP:0006293	absent olfactory placodes	"absence of the paired ectodermal placodes that come to lie in the bottom of the olfactory pits as the pits are deepened by the growth of the surrounding medial and lateral nasal processes " [J:71787, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Chrd^tm1Emdr/Chrd^tm1Emdr,Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J
MP:0006295	absent sclerotome	"absence of the group of mesenchymal cells that emerge from the ventromedial part of a somite and migrate toward the notochord to give rise to the ribs and vertebrae" [J:60303, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Chrd^tm1Emdr/Chrd^tm1Emdr,Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J Allelic Composition: Grem1^tm1Ecan/Grem1^tm1Ecan,Nog^tm1.1Rmh/Nog^tm1.1Rmh,Tmem163^{Tg(ACTB-cre)2Mrt}/0 Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N * SJL
MP:0006325	impaired hearing	"reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: L1cam^tm1Mtei/Y Genetic Background: either: (involves: 129/Sv * C57BL/6J) or (involves: 129/Sv * 129S/SvEv)
MP:0008023	abnormal styloid process morphology	"any structural abnormality in the slender needle-like pointed projection that runs downward and slightly forward from the base of the inferior surface of the petrous portion of the temporal bone where it joins the tympanic portion; it gives attachment to the styloglossus, stylohyoid, and stylopharyngeus muscles and the stylohyoid and stylomandibular ligaments" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: L1cam^tm1Mtei/Y Genetic Background: either: (involves: 129/Sv * C57BL/6J) or (involves: 129/Sv * 129S/SvEv)
MP:0008320	absent adenohypophysis	"absence of the anterior part of the pituitary that secretes a variety of hormones" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: either: (involves: 129S1/Sv * CD-1) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0008530	abnormal rostral-caudal patterning of the somites	"anomaly in the developmental pattern of the somites along the axis that runs from the head to the caudal region of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Disp1^tm1Pab/Disp1^tm1Pab Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0008817	hematoma	"an abnormal localized accumulation of clotted or partially clotted blood in an organ or a soft tissue space as a result of localized hemorrhage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv * CD-1
MP:0008926	abnormal anterior definitive endoderm morphology	"any structural anomaly of the mesendoderm which first migrates from the node and which gives rise to the gut" [PMID:12464432]	Show Allelic Composition: Nog^tm1Amc/Nog^tm1Amc,Smad3^tm1Xfw/Smad3⁺ Genetic Background: involves: 129/Sv * 129S1/Sv
MP:0009266	abnormal mesendoderm development	"failure or abnormality in the formation of the embryonic cell layer that gives rise to both the endoderm and mesoderm" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Chrd^tm1Emdr/Chrd^tm1Emdr,Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J Allelic Composition: Nog^tm1Amc/Nog^tm1Amc,Smad3^tm1Xfw/Smad3⁺ Genetic Background: involves: 129/Sv * 129S1/Sv
MP:0009570	abnormal right lung morphology	"any structural anomaly of the organ of respiration located on the right side of the body" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv
MP:0009735	abnormal prostate gland development	"anomaly in the formation or pattering of the of the prostate gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv * C57BL/6J * ICR
MP:0010029	abnormal basicranium morphology	"any structural anomaly of the sloping floor of the cranial cavity that is comprised of parts of the ethmoidal, occipital and sphenoid bones" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Cer1^tm1Belo/Cer1^tm1Belo,Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv
MP:0010103	small thoracic cage	"reduced size of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: L1cam^tm1Mtei/Y Genetic Background: either: (involves: 129/Sv * C57BL/6J) or (involves: 129/Sv * 129S/SvEv) Allelic Composition: Nog^tm1Amc/Nog⁺ Genetic Background: B6.129S1-Nog^tm1Amc Allelic Composition: Nog^tm1Amc/Nog⁺ Genetic Background: involves: 129S1/Sv * CD-1
MP:0010116	abnormal primitive urogenital sinus morphology	"any structural anomaly of the ventral part of the cloaca remaining after septation of the rectum, which further develops into part of the bladder, part of the prostatic part of the male urethra and the urethra and vestibule in females" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv * C57BL/6J * ICR
MP:0010884	esophagus stenosis	"abnormal narrowing or constriction of the esophagus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * CD-1 * ICR)
MP:0011089	complete perinatal lethality	"death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Disp1^tm1Pab/Disp1^tm1Pab Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: C57BL/6
MP:0011091	complete prenatal lethality	"death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Dst^dt-32J/Dst^dt-32J Genetic Background: involves: 129S/Sv * 129S2/SvPas
MP:0011099	complete lethality throughout fetal growth and development	"death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Chrd^tm1Emdr/Chrd^tm1Emdr,Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: B6.129S1-Nog^tm1Amc
MP:0011107	partial embryonic lethality before turning of embryo	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]	Show Allelic Composition: Chrd^tm1Emdr/Chrd^tm1Emdr,Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J
MP:0011108	partial embryonic lethality during organogenesis	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Chrd^tm1Emdr/Chrd^tm1Emdr,Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J
MP:0011259	abnormal cephalic neural fold morphology	"any structural anomaly of the elevated margins of the neural groove that are located in the future cephalic region of the embryo" [ISBN:0-683-40008-8, MGI:csmith]	Show Allelic Composition: Chrd^tm1Emdr/Chrd^tm1Emdr,Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J
MP:0011361	pelvic kidney	"an ectopic kidney located outside the renal fossa and within the pelvic cavity; pelvic kidneys may also, on occasion, occur as fused midline horseshoe kidneys" [MGI:anna]	Show Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv * C57BL/6J * ICR
MP:0011732	decreased somite size	"reduced size of any of the segmental masses along the notochord of the developing embryo" [MGI:smb]	Show Allelic Composition: Disp1^tm1Pab/Disp1^tm1Pab Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Grem1^tm1Ecan/Grem1^tm1Ecan,Nog^tm1.1Rmh/Nog^tm1.1Rmh,Tmem163^{Tg(ACTB-cre)2Mrt}/0 Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N * SJL Allelic Composition: Grem1^tm1Ecan/Grem1⁺,Nog^tm1.1Rmh/Nog^tm1.1Rmh,Tmem163^{Tg(ACTB-cre)2Mrt}/0 Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N * SJL
MP:0011759	absent Rathke s pouch	"absence of the diverticulum arsing from the embryonic buccal cavity from which the anterior lobe of the pituitary gland is developed" [MGI:anna]	Show Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: either: (involves: 129S1/Sv * CD-1) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0011967	increased or absent threshold for auditory brainstem response	"increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]	Show Allelic Composition: L1cam^tm1Mtei/Y Genetic Background: either: (involves: 129/Sv * C57BL/6J) or (involves: 129/Sv * 129S/SvEv)
MP:0012138	decreased forebrain size	"size reduction or truncation of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]	Show Allelic Composition: Chrd^tm1Emdr/Chrd^tm1Emdr,Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J
MP:0012176	abnormal head development	"anomaly in the process in which the anatomical structures of the head are generated and organized" [GO:0060323]	Show Allelic Composition: Grem1^tm1Ecan/Grem1^tm1Ecan,Nog^tm1.1Rmh/Nog^tm1.1Rmh,Tmem163^{Tg(ACTB-cre)2Mrt}/0 Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N * SJL
MP:0013351	abnormal Rathke s pouch development	"any anomaly in the formation of the pouch of ectoderm which grows out from the upper surface of the embryonic stomodeum and gives rise to the anterior and intermediate lobes of the pituitary gland" [MGI:Anna]	Show Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: either: (involves: 129S1/Sv * CD-1) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0013352	abnormal Rathke s pouch apoptosis	"any change in the timing or number of Rathke s pouch cells undergoing programmed cell death" [MGI:Anna]	Show Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: either: (involves: 129S1/Sv * CD-1) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0014198	absent pituitary infundibular stalk	"absence of the apical portion of the tubular structure extending from the hypothalamus to the posterior lobe of the pituitary gland" [MGI:Anna]	Show Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: either: (involves: 129S1/Sv * CD-1) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0030066	short face	"an abnormally decreased height (length) of the face" [MGI:anna]	Show Allelic Composition: Nog^tm1Amc/Nog^tm1Amc Genetic Background: involves: C57BL/6

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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