Manteia

ENSMUSG00000048755

Mus musculus

Features

Gene ID:	ENSMUSG00000048755

Biological name :	Mcat

Synonyms :	malonyl CoA:ACP acyltransferase (mitochondrial) / Mcat / Q8R3F5

Possible biological names infered from orthology :	malonyl-CoA-acyl carrier protein transacylase / Q8IVS2

Species:	Mus musculus

Chr. number:	15
Strand:	-1
Band:	E1
Gene start:	83546797
Gene end:	83563787

Corresponding Affymetrix probe sets:	10431030 (MoGene1.0st) 1452216_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000051569 Ensembl peptide - ENSMUSP00000155224 Ensembl peptide - ENSMUSP00000155428 Ensembl peptide - ENSMUSP00000155738 NCBI entrez gene - 223722 See in Manteia. MGI - MGI:2388651 RefSeq - NM_001030014 RefSeq - XM_006520815 RefSeq - XM_011245586 RefSeq Peptide - NP_001025185 swissprot - Q8R3F5 Ensembl - ENSMUSG00000048755

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
mcat	ENSDARG00000016613	Danio rerio
mcat	ENSDARG00000096473	Danio rerio
MCAT	ENSGALG00000034275	Gallus gallus
MCAT	ENSG00000100294	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR014043	Acyl transferase
IPR016035	Acyl transferase/acyl hydrolase/lysophospholipase
IPR016036	Malonyl-CoA ACP transacylase, ACP-binding
IPR020801	Polyketide synthase, acyl transferase domain

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006629	lipid metabolic process	IEA
biological_process	GO:0006631	fatty acid metabolic process	IEA
biological_process	GO:0006633	fatty acid biosynthetic process	IBA
biological_process	GO:0008152	metabolic process	IEA
cellular_component	GO:0005739	mitochondrion	ISO
molecular_function	GO:0004312	fatty acid synthase activity	IEA
molecular_function	GO:0004314	[acyl-carrier-protein] S-malonyltransferase activity	ISO
molecular_function	GO:0016740	transferase activity	ISO

Pathways (from Reactome)

Pathway description

Mitochondrial Fatty Acid Beta-Oxidation

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000160	kyphosis	"forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0000208	decreased hematocrit	"less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0000221	decreased WBC count	"fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0000240	extramedullary hematopoiesis	"formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0000414	alopecia	"absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0000493	rectal prolapse	"downward movement and external appearance of the rectum through the anus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0000691	enlarged spleen	"increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0000745	tremors	"repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0001242	hyperkeratosis	"increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0001263	weight loss	"progressive reduction of body weight below normal average for age" [J:45400]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0001402	hypoactivity	"reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0001406	abnormal gait	"unusual or distinctive way of walking" [J:65038]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0001412	excessive scratching	"compulsive scraping of the skin, usually with the nails" [J:61340]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0001417	decreased exploration in new environment	"less amount of time spent investigating a new location" [J:79870]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0001431	abnormal eating behavior	"inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0001510	abnormal coat appearance	"coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0001573	abnormal circulating alanine transaminase level	"aberrent concentration in the blood of this enzyme, whcih transfers amino groups from l-alanine to 2-ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0001577	anemia	"less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0001601	abnormal myelopoiesis	"atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0001783	decreased white fat amount	"reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0002106	abnormal muscle physiology	"anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0002118	abnormal lipid homeostasis	"anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0002424	abnormal reticulocyte morphology/development	"anomalous structure, formation, or numbers of immature erthrocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0002575	increased circulating ketone body level	"greater than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, J:71968]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0002590	increased mean corpuscular volume	"greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0002640	reticulocytosis	"an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0002722	abnormal immune system organ morphology	"anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0002757	reduced vertical activity	"lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0002874	decreased hemoglobin content	"decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0002875	decreased erythrocyte count	"reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0003019	increased circulating chloride level	"elevated concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0003293	rectal hemorrhage	"bleeding in the rectum" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0003656	abnormal erythrocyte physiology	"functional anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0003853	dry skin	"skin characterized by the lack of natural or normal moisture" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0005016	decreased lymphocyte number	"fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0005534	decreased body temperature	"less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0005559	increased circulating glucose level	"greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0006036	abnormal mitochondrial physiology		Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0008844	decreased subcutaneous adipose tissue amount	"reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0010053	decreased grip strength	"reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0010067	increased red blood cell distribution width	"higher than normal coefficient of variance (reference range) of the red blood cell volume for an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", NCI:C64800 "NCI Thesaurus (Code C64800)"]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0010072	increased pruritus	"abnormal presence or increased intensity of an uncomfortable sensation resulting from irritation of the skin or mucous membranes that evokes the desire or reflex to rub or scratch" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0010401	increased skeletal muscle glycogen level	"greater than the normal concentration of a readily converted carbohydrate reserve in skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0010954	abnormal cellular respiration	"anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0012106	impaired exercise endurance	"impaired performance during controlled physical activity" [MGI:smb]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}
MP:0013405	increased circulating lactate level	"greater amount of lactate in the blood which is produced from pyruvate by lactate dehydrogenase" [MPD:Molly]	Show Allelic Composition: Zdhhc13^{Gt(AC0492)Wtsi}/Zdhhc13^{Gt(AC0492)Wtsi} Genetic Background: FVB.129P2-Zdhhc13^{Gt(AC0492)Wtsi}

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000030869	Q9CR21 / Ndufab1 / NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1 / O14561* / NADH:ubiquinone oxidoreductase subunit AB1*	/ reaction

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr