ENSMUSG00000049109


Mus musculus

Features
Gene ID: ENSMUSG00000049109
  
Biological name :Themis
  
Synonyms : Q8BGW0 / Themis / thymocyte selection associated
  
Possible biological names infered from orthology : Q8N1K5
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: A4
Gene start: 28668360
Gene end: 28883818
  
Corresponding Affymetrix probe sets: 10362350 (MoGene1.0st)   1436423_at (Mouse Genome 430 2.0 Array)   1439719_at (Mouse Genome 430 2.0 Array)   1442022_at (Mouse Genome 430 2.0 Array)   1443192_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123894
Ensembl peptide - ENSMUSP00000124451
Ensembl peptide - ENSMUSP00000123919
Ensembl peptide - ENSMUSP00000055315
Ensembl peptide - ENSMUSP00000060129
Ensembl peptide - ENSMUSP00000101155
NCBI entrez gene - 210757     See in Manteia.
MGI - MGI:2443552
RefSeq - NM_001305663
RefSeq - NM_178666
RefSeq Peptide - NP_001292592
RefSeq Peptide - NP_848781
swissprot - Q8BGW0
swissprot - E0CY68
swissprot - E0CYT7
Ensembl - ENSMUSG00000049109
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A5PF62ENSDARG00000010619Danio rerio
 THEMISENSGALG00000014821Gallus gallus
 Q8N1K5ENSG00000172673Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q91YX0 / Themis2 / Protein THEMIS2 / Q5TEJ8* / thymocyte selection associated family member 2*ENSMUSG0000003773131
Q9CU24 / Themis3 / Protein THEMIS3 ENSMUSG0000002410523


Protein motifs (from Interpro)
Interpro ID Name
 IPR025946  CABIT domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0043368 positive T cell selection IMP
 biological_processGO:0043383 negative T cell selection IMP
 biological_processGO:0050852 T cell receptor signaling pathway IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0008180 COP9 signalosome IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Rb1tm1Brn/Rb1+,X/Tg(Pomc-FLP)1bBrn
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Themistm1Hasu/Themistm1Hasu
Genetic Background: involves: C57BL/6 * CBA

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Cryba1tm1a(EUCOMM)Hmgu/Cryba1tm1a(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0001825 arrested T cell development "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Themis5AT161/Themis5AT161
Genetic Background: involves: C57BL/6

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Egfl7Gt(1-13)Stmn/Egfl7Gt(1-13)Stmn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Tg(CD2-Zbtb7b)C8Rbo/?,Themistm1Lov/Themistm1Lov
Genetic Background: involves: 129

Allelic Composition: ThemisSpotr/ThemisSpotr
Genetic Background: C57BL/6-ThemisSpotr

Allelic Composition: Themistm1Hasu/Themistm1Hasu
Genetic Background: involves: C57BL/6 * CBA

 MP:0002375 abnormal thymus medulla morphology "anomalous structure or development of the inner area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rb1tm1Brn/Rb1+,X/Tg(Pomc-FLP)1bBrn
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0002436 abnormal cytotoxic T cell morphology/development "anomalous structure, formation, or numbers of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Zap70m7Btlr/Zap70m7Btlr
Genetic Background: C57BL/6J-Zap70m7Btlr

 MP:0002619 abnormal lymphocyte morphology/development "anomalous structure, differentiation, or number of the white blood cells formed in the body s lymphoid tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fbn2fp-4J/Fbn2fp-4J
Genetic Background: BALB/cByJ-Fbn2fp-4J/GrsrJ

 MP:0004918 abnormal negative T cell selection "any anomaly in the process of elimination of immature T cells which react strongly with self-antigens" [GO:0043383]
Show

Allelic Composition: Rb1tm1Brn/Rb1+,X/Tg(Pomc-FLP)1bBrn
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Tg(TcraH-Y,TcrbH-Y)71Vbo/?,Themistm1Gasc/Themistm1Gasc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Themistm1Lov/Themistm1Lov
Genetic Background: involves: 129

Allelic Composition: Tg(TcraH-Y,TcrbH-Y)71Vbo/?,Themistm1Lov/Themistm1Lov
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Themistm1Lov/Themistm1Lov
Genetic Background: involves: 129

 MP:0004919 abnormal positive T cell selection "any anomaly in the process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death" [GO:0043368]
Show

Allelic Composition: Rb1tm1Brn/Rb1+,X/Tg(Pomc-FLP)1bBrn
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Tg(TcraH-Y,TcrbH-Y)71Vbo/?,Themistm1Gasc/Themistm1Gasc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Tg(TcraTcrb)1100Mjb/?,Themistm1Gasc/Themistm1Gasc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Tg(TcrAND)53Hed/?,Themistm1Gasc/Themistm1Gasc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Tg(TcraH-Y,TcrbH-Y)71Vbo/?,Themistm1Lov/Themistm1Lov
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: Tg(TcrAND)53Hed/?,Themistm1Lov/Themistm1Lov
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0004941 abnormal regulatory T cell morphology "any structural anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or Tregs) and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rb1tm1Brn/Rb1+,X/Tg(Pomc-FLP)1bBrn
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Themistm1Lov/Themistm1Lov
Genetic Background: involves: 129

Allelic Composition: Themis5AT161/Themis5AT161
Genetic Background: involves: C57BL/6

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cryba1tm1a(EUCOMM)Hmgu/Cryba1tm1a(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0005091 increased double-positive T cell count "greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Rb1tm1Brn/Rb1+,X/Tg(Pomc-FLP)1bBrn
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Tg(TcraTcrb)1100Mjb/?,Themistm1Gasc/Themistm1Gasc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Tg(TcrAND)53Hed/?,Themistm1Gasc/Themistm1Gasc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Tg(TcraH-Y,TcrbH-Y)71Vbo/?,Themistm1Lov/Themistm1Lov
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: Tg(TcrAND)53Hed/?,Themistm1Lov/Themistm1Lov
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Tg(Tcra5CC7,Tcrb5CC7)IWep/?,Themis5AT161/Themis5AT161
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Rb1tm1Brn/Rb1+,X/Tg(Pomc-FLP)1bBrn
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Themistm1Hasu/Themistm1Hasu
Genetic Background: involves: C57BL/6 * CBA

 MP:0008049 increased memory T cell number "greater number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Themistm1Lov/Themistm1Lov
Genetic Background: involves: 129

Allelic Composition: Themistm1Hasu/Themistm1Hasu
Genetic Background: involves: C57BL/6 * CBA

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rb1tm1Brn/Rb1+,X/Tg(Pomc-FLP)1bBrn
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Tg(TcrAND)53Hed/?,Themistm1Gasc/Themistm1Gasc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Themistm1Lov/Themistm1Lov
Genetic Background: involves: 129

Allelic Composition: Themis5AT161/Themis5AT161
Genetic Background: involves: C57BL/6

Allelic Composition: ThemisSpotr/ThemisSpotr
Genetic Background: C57BL/6-ThemisSpotr

Allelic Composition: ThemisSpotr/Themis+
Genetic Background: C57BL/6-ThemisSpotr

Allelic Composition: Themistm1.1Hko/Themistm1.1Hko
Genetic Background: Not Specified

Allelic Composition: Themistm1.1Hko/Themis+
Genetic Background: Not Specified

Allelic Composition: Themistm1Hasu/Themistm1Hasu
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Themistm1Hasu/Themis+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Themism1Btlr/Themism1Btlr
Genetic Background: C57BL/6J-Themism1Btlr

Allelic Composition: Themism2Btlr/Themism2Btlr
Genetic Background: C57BL/6J-Themism2Btlr

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Themism2Btlr/Themism2Btlr
Genetic Background: C57BL/6J-Themism2Btlr

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rb1tm1Brn/Rb1+,X/Tg(Pomc-FLP)1bBrn
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Tg(TcraTcrb)1100Mjb/?,Themistm1Gasc/Themistm1Gasc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Tg(TcrAND)53Hed/?,Themistm1Gasc/Themistm1Gasc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Themistm1Lov/Themistm1Lov
Genetic Background: involves: 129

Allelic Composition: Themis5AT161/Themis5AT161
Genetic Background: involves: C57BL/6

Allelic Composition: ThemisSpotr/ThemisSpotr
Genetic Background: C57BL/6-ThemisSpotr

Allelic Composition: ThemisSpotr/Themis+
Genetic Background: C57BL/6-ThemisSpotr

Allelic Composition: Themistm1.1Hko/Themistm1.1Hko
Genetic Background: Not Specified

Allelic Composition: Themistm1.1Hko/Themis+
Genetic Background: Not Specified

Allelic Composition: Themistm1Hasu/Themistm1Hasu
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Themistm1Hasu/Themis+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Themism1Btlr/Themism1Btlr
Genetic Background: C57BL/6J-Themism1Btlr

 MP:0008080 abnormal CD8-positive T cell differentiation "atypical production of or inability to produce the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Themistm1Lov/Themistm1Lov
Genetic Background: involves: 129

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Themistm1Lov/Themistm1Lov
Genetic Background: involves: 129

Allelic Composition: Tg(TcraH-Y,TcrbH-Y)71Vbo/?,Themistm1Lov/Themistm1Lov
Genetic Background: involves: 129 * C57BL/6 * DBA/2

Allelic Composition: Tg(TcrAND)53Hed/?,Themistm1Lov/Themistm1Lov
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Themis5AT161/Themis5AT161
Genetic Background: involves: C57BL/6

Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Tg(TcraH-Y,TcrbH-Y)71Vbo/?,Themis5AT161/Themis5AT161
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

Allelic Composition: Themistm1.1Hko/Themistm1.1Hko
Genetic Background: Not Specified

 MP:0008168 decreased B-1a cell number "reduced number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
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Allelic Composition: Themism1Btlr/Themism1Btlr
Genetic Background: C57BL/6J-Themism1Btlr

 MP:0009339 decreased splenocyte number "reduction in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Themistm1Hasu/Themistm1Hasu
Genetic Background: involves: C57BL/6 * CBA

 MP:0010168 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number "a greater number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]
Show

Allelic Composition: Zap70m7Btlr/Zap70m7Btlr
Genetic Background: C57BL/6J-Zap70m7Btlr

 MP:0010169 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number "a reduction in the number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]
Show

Allelic Composition: Zap70m7Btlr/Zap70m7Btlr
Genetic Background: C57BL/6J-Zap70m7Btlr

 MP:0010833 abnormal memory T cell morphology "any structural anomaly of distinctly differentiated long-lived T cells that have the phenotype CD45RO-positive and CD127-positive" [CL:0000813, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, ISBN:0781735149]
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Allelic Composition: Rb1tm1Brn/Rb1+,X/Tg(Pomc-FLP)1bBrn
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0010838 increased CD8-positive, alpha-beta memory T cell number "increased number of CD8-positive, alpha-beta T cells with memory phenotype indicated by being CD45RO and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high" [CL:0000909, GO_REF:0000031, GOC:tfm, PMID:20146720]
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Allelic Composition: Zap70m7Btlr/Zap70m7Btlr
Genetic Background: C57BL/6J-Zap70m7Btlr

 MP:0010839 decreased CD8-positive, alpha-beta memory T cell number "decreased number of CD8-positive, alpha-beta T cells with memory phenotype indicated by being CD45RO and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high" [CL:0000909, GO_REF:0000031, GOC:tfm, PMID:20146720]
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Allelic Composition: Zap70m7Btlr/Zap70m7Btlr
Genetic Background: C57BL/6J-Zap70m7Btlr

 MP:0010841 increased central memory CD4-positive, alpha-beta T cell number "increased number of CD4-positive, alpha-beta memory T cells with the phenotype CCR7-positive, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000904, GO_REF:0000031, GOC:add, GOC:pam]
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Allelic Composition: Zap70m7Btlr/Zap70m7Btlr
Genetic Background: C57BL/6J-Zap70m7Btlr

 MP:0010844 increased effector memory CD4-positive, alpha-beta T cell number "increased number of CD4-positive, alpha-beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000905, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm]
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Allelic Composition: Themism2Btlr/Themism2Btlr
Genetic Background: C57BL/6J-Themism2Btlr

Allelic Composition: Themism3Btlr/Themism3Btlr
Genetic Background: C57BL/6J-Themism3Btlr

 MP:0010847 increased central memory CD8 positive, alpha-beta T cell number "increased number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-positive, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000907, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:20146720]
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Allelic Composition: Themism3Btlr/Themism3Btlr
Genetic Background: C57BL/6J-Themism3Btlr

 MP:0013435 decreased CD8-positive, naive alpha-beta T cell number "reduction in the number of the naïve regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions with a CD44-low CD62L+ phenotype" [IMPC:Saran]
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Allelic Composition: Themism3Btlr/Themism3Btlr
Genetic Background: C57BL/6J-Themism3Btlr

 MP:0013588 small thymus medulla "decreased size of the inner area of thymus lobules" [MGI:Anna]
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Allelic Composition: ThemisSpotr/ThemisSpotr
Genetic Background: C57BL/6-ThemisSpotr

 MP:0020154 impaired humoral immune response "impaired response of the immune system that mediates secreted antibodies produced in B cells" [GOC:NV]
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Allelic Composition: Themism1Btlr/Themism1Btlr
Genetic Background: C57BL/6J-Themism1Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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