ENSMUSG00000049555


Mus musculus

Features
Gene ID: ENSMUSG00000049555
  
Biological name :Tmie
  
Synonyms : Q8K467 / Tmie / transmembrane inner ear
  
Possible biological names infered from orthology : Q8NEW7
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: F2
Gene start: 110865711
Gene end: 110880113
  
Corresponding Affymetrix probe sets: 10597258 (MoGene1.0st)   1439838_a_at (Mouse Genome 430 2.0 Array)   1441926_x_at (Mouse Genome 430 2.0 Array)   1443964_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000060148
NCBI entrez gene - 20776     See in Manteia.
MGI - MGI:2159400
RefSeq - XM_011242945
RefSeq - NM_146260
RefSeq - XM_006512013
RefSeq - XM_006512014
RefSeq - XM_011242944
RefSeq - XM_006512007
RefSeq - XM_006512008
RefSeq - XM_006512009
RefSeq - XM_006512010
RefSeq Peptide - NP_666372
swissprot - Q8K467
swissprot - B2RSF0
Ensembl - ENSMUSG00000049555
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tmieENSDARG00000069423Danio rerio
 TMIEENSGALG00000005443Gallus gallus
 TMIEENSG00000181585Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR032006  Transmembrane inner ear expressed protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007605 sensory perception of sound IMP
 biological_processGO:0042472 inner ear morphogenesis IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(CAG-Bgeo,-Fgf4)1Mrt/?,Tg(Msx2-cre)5Rem/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0001382 abnormal nursing "females do not nurse pups or nurse pups infrequently" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tmiesr/Tmiesr
Genetic Background: C57BL/How-Tmiesr

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
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Allelic Composition: Myo7ash1/Myo7ash1
Genetic Background: SH1/LeJ

Allelic Composition: cir/cir+,Tmiesr/Tmie+
Genetic Background: involves: C57BL/6J * C57BL/How * ICR

Allelic Composition: Tmiesr-2J/Tmiesr-2J
Genetic Background: B6(Cg)-Tmiesr-2J/J

Allelic Composition: Tmiesr-J/Tmiesr-J
Genetic Background: involves: A/J * C57BL/6J

 MP:0001395 bi-directional circling "circling behavior exhibited in both clockwise and counterclockwise directions" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Tmiesr/Tmiesr
Genetic Background: C57BL/How-Tmiesr

 MP:0001486 abnormal startle reflex "abberant threshold or reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Nphp3pol/Nphp3pol
Genetic Background: C57BL/6JSfdAnu-Nphp3pol/Anu

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
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Allelic Composition: Myo7ash1/Myo7ash1
Genetic Background: SH1/LeJ

Allelic Composition: Tmiesr/Tmiesr
Genetic Background: C57BL/How-Tmiesr

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Myo7ash1/Myo7ash1
Genetic Background: SH1/LeJ

Allelic Composition: cir/cir+,Tmiesr/Tmie+
Genetic Background: involves: C57BL/6J * C57BL/How * ICR

 MP:0001961 abnormal reflex "anomalies in an involuntary response to a peripheral stimulus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Myo7ash1/Myo7ash1
Genetic Background: SH1/LeJ

Allelic Composition: Tmiesr/Tmiesr
Genetic Background: C57BL/How-Tmiesr

 MP:0001967 deafness "inability to hear" [J:57651]
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Allelic Composition: Tmiesr/Tmiesr
Genetic Background: C57BL/How-Tmiesr

Allelic Composition: Tmiesr-2J/Tmiesr-2J
Genetic Background: B6(Cg)-Tmiesr-2J/J

 MP:0002730 head shaking "compulsive movement of the head in the horizontal plane" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:274]
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Allelic Composition: Tmiesr/Tmiesr
Genetic Background: C57BL/How-Tmiesr

Allelic Composition: Tmiesr-J/Tmiesr-J
Genetic Background: involves: A/J * C57BL/6J

 MP:0002857 cochlear ganglion degeneration "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tmiesr/Tmiesr
Genetic Background: C57BL/How-Tmiesr

 MP:0003150 detached tectorial membrane "tectorial membrane is abnormally detached from the cochlear epithelium or spiral limbus" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:77634]
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Allelic Composition: Tmiesr/Tmiesr
Genetic Background: C57BL/How-Tmiesr

 MP:0004331 saccular macula degeneration "degeneration or loss of the oval neuroepithelial sensory receptor in the anterior wall of the saccule" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tmiesr/Tmiesr
Genetic Background: C57BL/How-Tmiesr

 MP:0004362 cochlear hair cell degeneration "degeneration or loss of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tmiesr/Tmiesr
Genetic Background: C57BL/How-Tmiesr

 MP:0004813 absent linear vestibular evoked potential "absence of the biphasic response elicited by linear acceleration transients (usually jerk pulses to an animal s head)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo7ash1/Myo7ash1
Genetic Background: SH1/LeJ

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo7ash1/Myo7ash1
Genetic Background: SH1/LeJ

Allelic Composition: cir/cir+,Tmiesr/Tmie+
Genetic Background: involves: C57BL/6J * C57BL/How * ICR

Allelic Composition: Tmiesr-J/Tmiesr-J
Genetic Background: involves: A/J * C57BL/6J

 MP:0005191 head tilt "condition in which the portion of the body containing the brain and organs of sight, hearing, taste, and smell lists to the side" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tmiesr-2J/Tmiesr-2J
Genetic Background: B6(Cg)-Tmiesr-2J/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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