ENSMUSG00000049686


Mus musculus

Features
Gene ID: ENSMUSG00000049686
  
Biological name :Orai1
  
Synonyms : Orai1 / ORAI calcium release-activated calcium modulator 1 / Q8BWG9
  
Possible biological names infered from orthology : Q96D31
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: F
Gene start: 123015074
Gene end: 123030456
  
Corresponding Affymetrix probe sets: 10525464 (MoGene1.0st)   1424989_at (Mouse Genome 430 2.0 Array)   1424990_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113097
Ensembl peptide - ENSMUSP00000058169
NCBI entrez gene - 109305     See in Manteia.
MGI - MGI:1925542
RefSeq - NM_175423
RefSeq Peptide - NP_780632
swissprot - A3KCG1
swissprot - Q8BWG9
Ensembl - ENSMUSG00000049686
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 orai1aENSDARG00000011515Danio rerio
 orai1bENSDARG00000004154Danio rerio
 ORAI1ENSGALG00000004240Gallus gallus
 ORAI1ENSG00000276045Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Orai2 / Q8BH10 / Protein orai-2 / Q96SN7* / ORAI calcium release-activated calcium modulator 2*ENSMUSG0000003974752
Orai3 / Q6P8G8 / Protein orai-3 / Q9BRQ5* / ORAI calcium release-activated calcium modulator 3*ENSMUSG0000004396451


Protein motifs (from Interpro)
Interpro ID Name
 IPR012446  Calcium release-activated calcium channel protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002115 store-operated calcium entry ISO
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0051924 regulation of calcium ion transport ISO
 biological_processGO:0051928 positive regulation of calcium ion transport ISO
 biological_processGO:0061180 mammary gland epithelium development IMP
 biological_processGO:0070509 calcium ion import IDA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 cellular_componentGO:0005776 autophagosome IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0015279 store-operated calcium channel activity IBA
 molecular_functionGO:0042802 identical protein binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
Show

Allelic Composition: Rtl1tm1Fuis/Rtl1+
Genetic Background: involves: 129S/SvEv * DBA/2

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Orai1tm1.1Hjm/Orai1tm1.1Hjm,Orai2tm1.1(KOMP)Vlcg/Orai2tm1.1(KOMP)Vlcg,Tg(Cd4-cre)1Cwi/0
Genetic Background: B6.Cg-Orai1tm1.1Hjm Orai2tm1.1(KOMP)Vlcg Tg(Cd4-cre)1Cwi

 MP:0001199 thin skin "reduced thickness of the outer protective layer of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
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Allelic Composition: Rtl1tm1Fuis/Rtl1+
Genetic Background: involves: 129S/SvEv * DBA/2

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Rtl1tm1Fuis/Rtl1+
Genetic Background: involves: 129S/SvEv * DBA/2

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Rtel1tm1.1Hdin/Rtel1tm1.1Hdin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0001282 short vibrissae "decreased length of the vibrissae" [J:30249]
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Allelic Composition: Rtl1tm1Fuis/Rtl1+
Genetic Background: involves: 129S/SvEv * DBA/2

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Orai1tm1.1Hjm/Orai1tm1.1Hjm,Orai2tm1.1(KOMP)Vlcg/Orai2tm1.1(KOMP)Vlcg,Tg(Cd4-cre)1Cwi/0
Genetic Background: B6.Cg-Orai1tm1.1Hjm Orai2tm1.1(KOMP)Vlcg Tg(Cd4-cre)1Cwi

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Rtl1tm1Fuis/Rtl1+
Genetic Background: involves: 129S/SvEv * DBA/2

Allelic Composition: Orai1tm1Rao/Orai1tm1Rao
Genetic Background: involves: C57BL/6NTac * ICR

 MP:0002421 abnormal cell-mediated immunity "abnormal function of any adaptive immune response in which T cells play a main role " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rtl1tm1Fuis/Rtl1+
Genetic Background: involves: 129S/SvEv * DBA/2

 MP:0002423 abnormal mast cell physiology "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rtel1tm1.1Hdin/Rtel1tm1.1Hdin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

Allelic Composition: Orai1Gt(XL922)Byg/Orai1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Orai1tm1Rao/Orai1tm1Rao
Genetic Background: involves: C57BL/6NTac * ICR

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kcnt1tm1.2Clin/Kcnt1tm1.2Clin,Kcnt2tm1.2Clin/Kcnt2tm1.2Clin
Genetic Background: B6.Cg-Kcnt2tm1.2Clin Kcnt1tm1.2Clin

Allelic Composition: Orai1tm1.1Hjm/Orai1tm1.1Hjm,Tg(Cd4-cre)1Cwi/0
Genetic Background: B6.Cg-Orai1tm1.1Hjm Tg(Cd4-cre)1Cwi

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Orai1tm1Rao/Orai1tm1Rao
Genetic Background: involves: C57BL/6NTac * ICR

 MP:0003850 abnormal thymocyte activation/response "anomaly in the process of producing activated thymocytes from naive thymocytes" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Orai1tm1Rao/Orai1tm1Rao
Genetic Background: involves: C57BL/6NTac * ICR

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Btkxid/Y,Ikzf3tm1Kge/Ikzf3tm1Kge
Genetic Background: involves: 129S4/SvJae * CBA/CaHN

 MP:0004867 decreased platelet calcium level "decreased concentration in the platelet of this bivalent element" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Gabra1tm1Geh/Gabra1tm1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Orai1tm1.1Hjm/Orai1tm1.1Hjm,Orai2tm1.1(KOMP)Vlcg/Orai2tm1.1(KOMP)Vlcg,Tg(Cd4-cre)1Cwi/0
Genetic Background: B6.Cg-Orai1tm1.1Hjm Orai2tm1.1(KOMP)Vlcg Tg(Cd4-cre)1Cwi

 MP:0005251 blepharitis "inflammation of the eyelids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Orai1tm1Rao/Orai1tm1Rao
Genetic Background: involves: C57BL/6NTac * ICR

 MP:0005597 decreased susceptibility to type I hypersensitivity reaction "less likelihood or resistance to developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, J:68588, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rtel1tm1.1Hdin/Rtel1tm1.1Hdin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rtl1tm1Fuis/Rtl1+
Genetic Background: involves: 129S/SvEv * DBA/2

 MP:0006298 abnormal platelet activation "anomaly in the series of progressive, overlapping events triggered by exposure of platelets to signals from subendothelial tissue, including shape change, adhesiveness, aggregation, and release reactions; when carried through to completion, these events lead to the formation of a stable hemostatic plug" [GO:0030168, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gabra1tm1Geh/Gabra1tm1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Orai1tm1.1Hjm/Orai1tm1.1Hjm,Orai2tm1.1(KOMP)Vlcg/Orai2tm1.1(KOMP)Vlcg,Tg(Cd4-cre)1Cwi/0
Genetic Background: B6.Cg-Orai1tm1.1Hjm Orai2tm1.1(KOMP)Vlcg Tg(Cd4-cre)1Cwi

 MP:0008102 lymph node hyperplasia "overdevelopment or increased size, usually due to increased cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Orai1tm1.1Hjm/Orai1tm1.1Hjm,Orai2tm1.1(KOMP)Vlcg/Orai2tm1.1(KOMP)Vlcg,Tg(Cd4-cre)1Cwi/0
Genetic Background: B6.Cg-Orai1tm1.1Hjm Orai2tm1.1(KOMP)Vlcg Tg(Cd4-cre)1Cwi

 MP:0008178 decreased germinal center B cell number "reduced number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Orai1tm1.1Hjm/Orai1tm1.1Hjm,Orai2tm1.1(KOMP)Vlcg/Orai2tm1.1(KOMP)Vlcg,Tg(Cd4-cre)1Cwi/0
Genetic Background: B6.Cg-Orai1tm1.1Hjm Orai2tm1.1(KOMP)Vlcg Tg(Cd4-cre)1Cwi

 MP:0008217 abnormal B cell activation "any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rtl1tm1Fuis/Rtl1+
Genetic Background: involves: 129S/SvEv * DBA/2

Allelic Composition: Orai1tm1Rao/Orai1tm1Rao
Genetic Background: involves: C57BL/6NTac * ICR

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Rtel1tm1.1Hdin/Rtel1tm1.1Hdin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

Allelic Composition: Orai1Gt(XL922)Byg/Orai1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Orai1tm1Rao/Orai1tm1Rao
Genetic Background: involves: C57BL/6NTac * ICR

 MP:0008661 decreased interleukin-10 secretion "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Orai1tm1Rao/Orai1tm1Rao
Genetic Background: involves: C57BL/6NTac * ICR

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Rtel1tm1.1Hdin/Rtel1tm1.1Hdin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

Allelic Composition: Orai1tm1Rao/Orai1tm1Rao
Genetic Background: involves: C57BL/6NTac * ICR

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Orai1tm1Rao/Orai1tm1Rao
Genetic Background: involves: C57BL/6NTac * ICR

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Orai1tm1Rao/Orai1tm1Rao
Genetic Background: involves: C57BL/6NTac * ICR

 MP:0009817 decreased leukotriene level "reduced concentration of a family of mediators derived from arachidonic acid which normally stimulate smooth muscle contraction, increase vascular permeability, and may be chemoattractants for inflammatory cells" [ISBN:0-397-51047-0 "Rubin E, et al. Pathology, 2nd edition"]
Show

Allelic Composition: Rtel1tm1.1Hdin/Rtel1tm1.1Hdin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

Allelic Composition: Orai1Gt(XL922)Byg/Orai1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0010183 abnormal CD4-positive helper T cell morphology "any structural anomaly of a CD4-positive, alpha-beta T cell that cooperates with other lymphocytes via direct contact or cytokine release to initiate a variety of immune functions" [CL:0000492, ISBN:0781735149]
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Allelic Composition: Orai1tm1.1Hjm/Orai1tm1.1Hjm,Orai2tm1.1(KOMP)Vlcg/Orai2tm1.1(KOMP)Vlcg,Tg(Cd4-cre)1Cwi/0
Genetic Background: B6.Cg-Orai1tm1.1Hjm Orai2tm1.1(KOMP)Vlcg Tg(Cd4-cre)1Cwi

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Gabra1tm1Geh/Gabra1tm1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Rtl1tm1Fuis/Rtl1+
Genetic Background: involves: 129S/SvEv * DBA/2

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Orai1tm1Rao/Orai1tm1Rao
Genetic Background: involves: C57BL/6NTac * ICR

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Rtl1tm1Fuis/Rtl1+
Genetic Background: involves: 129S/SvEv * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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