Manteia - Molecule gene

ENSMUSG00000039747

Mus musculus

Features

Gene ID:	ENSMUSG00000039747

Biological name :	Orai2

Synonyms :	Orai2 / Protein orai-2 / Q8BH10

Possible biological names infered from orthology :	ORAI calcium release-activated calcium modulator 2 / Q96SN7

Species:	Mus musculus

Chr. number:	5
Strand:	-1
Band:	G2
Gene start:	136147459
Gene end:	136170713

Corresponding Affymetrix probe sets:	10436426 (MoGene1.0st) 10534570 (MoGene1.0st) 1434762_at (Mouse Genome 430 2.0 Array) 1434763_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000143219 Ensembl peptide - ENSMUSP00000037137 Ensembl peptide - ENSMUSP00000142597 NCBI entrez gene - 269717 See in Manteia. MGI - MGI:2443195 RefSeq - XM_006504431 RefSeq - NM_178751 RefSeq - XM_006504429 RefSeq - XM_006504430 RefSeq Peptide - NP_848866 swissprot - Q14BR6 swissprot - Q8BH10 swissprot - A5CVE1 swissprot - A0A0G2JFL5 Ensembl - ENSMUSG00000039747

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
orai2	ENSDARG00000035148	Danio rerio
ORAI2	ENSGALG00000001837	Gallus gallus
ORAI2	ENSG00000160991	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Orai1 / Q8BWG9 / ORAI calcium release-activated calcium modulator 1 / Q96D31*	ENSMUSG00000049686	63
Orai3 / Q6P8G8 / Protein orai-3 / Q9BRQ5* / ORAI calcium release-activated calcium modulator 3*	ENSMUSG00000043964	59

Protein motifs (from Interpro)

Interpro ID	Name
IPR012446	Calcium release-activated calcium channel protein
IPR030034	Protein Orai-2

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0002115	store-operated calcium entry	IBA
biological_process	GO:0070588	calcium ion transmembrane transport	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0015279	store-operated calcium channel activity	IBA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000693	spleen hyperplasia	"increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]	Show Allelic Composition: Orai1^tm1.1Hjm/Orai1^tm1.1Hjm,Orai2^{tm1.1(KOMP)Vlcg}/Orai2^{tm1.1(KOMP)Vlcg},Tg(Cd4-cre)1Cwi/0 Genetic Background: B6.Cg-Orai1^tm1.1Hjm Orai2^{tm1.1(KOMP)Vlcg} Tg(Cd4-cre)1Cwi
MP:0001805	decreased IgG	"less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Orai1^tm1.1Hjm/Orai1^tm1.1Hjm,Orai2^{tm1.1(KOMP)Vlcg}/Orai2^{tm1.1(KOMP)Vlcg},Tg(Cd4-cre)1Cwi/0 Genetic Background: B6.Cg-Orai1^tm1.1Hjm Orai2^{tm1.1(KOMP)Vlcg} Tg(Cd4-cre)1Cwi
MP:0002444	abnormal T cell physiology	"anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Kcnt1^tm1.2Clin/Kcnt1^tm1.2Clin,Kcnt2^tm1.2Clin/Kcnt2^tm1.2Clin Genetic Background: B6.Cg-Kcnt2^tm1.2Clin Kcnt1^tm1.2Clin Allelic Composition: Orai1^tm1.1Hjm/Orai1^tm1.1Hjm,Orai2^{tm1.1(KOMP)Vlcg}/Orai2^{tm1.1(KOMP)Vlcg},Tg(Cd4-cre)1Cwi/0 Genetic Background: B6.Cg-Orai1^tm1.1Hjm Orai2^{tm1.1(KOMP)Vlcg} Tg(Cd4-cre)1Cwi
MP:0002451	abnormal macrophage physiology	"abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Kcnt1^tm1.2Clin/Kcnt1^tm1.2Clin,Kcnt2^tm1.2Clin/Kcnt2^tm1.2Clin Genetic Background: B6.Cg-Kcnt2^tm1.2Clin Kcnt1^tm1.2Clin
MP:0004974	decreased regulatory T cell number	"reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Orai1^tm1.1Hjm/Orai1^tm1.1Hjm,Orai2^{tm1.1(KOMP)Vlcg}/Orai2^{tm1.1(KOMP)Vlcg},Tg(Cd4-cre)1Cwi/0 Genetic Background: B6.Cg-Orai1^tm1.1Hjm Orai2^{tm1.1(KOMP)Vlcg} Tg(Cd4-cre)1Cwi
MP:0008083	decreased single-positive T cell number	"reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Orai1^tm1.1Hjm/Orai1^tm1.1Hjm,Orai2^{tm1.1(KOMP)Vlcg}/Orai2^{tm1.1(KOMP)Vlcg},Tg(Cd4-cre)1Cwi/0 Genetic Background: B6.Cg-Orai1^tm1.1Hjm Orai2^{tm1.1(KOMP)Vlcg} Tg(Cd4-cre)1Cwi
MP:0008102	lymph node hyperplasia	"overdevelopment or increased size, usually due to increased cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Orai1^tm1.1Hjm/Orai1^tm1.1Hjm,Orai2^{tm1.1(KOMP)Vlcg}/Orai2^{tm1.1(KOMP)Vlcg},Tg(Cd4-cre)1Cwi/0 Genetic Background: B6.Cg-Orai1^tm1.1Hjm Orai2^{tm1.1(KOMP)Vlcg} Tg(Cd4-cre)1Cwi
MP:0008178	decreased germinal center B cell number	"reduced number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]	Show Allelic Composition: Orai1^tm1.1Hjm/Orai1^tm1.1Hjm,Orai2^{tm1.1(KOMP)Vlcg}/Orai2^{tm1.1(KOMP)Vlcg},Tg(Cd4-cre)1Cwi/0 Genetic Background: B6.Cg-Orai1^tm1.1Hjm Orai2^{tm1.1(KOMP)Vlcg} Tg(Cd4-cre)1Cwi
MP:0010183	abnormal CD4-positive helper T cell morphology	"any structural anomaly of a CD4-positive, alpha-beta T cell that cooperates with other lymphocytes via direct contact or cytokine release to initiate a variety of immune functions" [CL:0000492, ISBN:0781735149]	Show Allelic Composition: Orai1^tm1.1Hjm/Orai1^tm1.1Hjm,Orai2^{tm1.1(KOMP)Vlcg}/Orai2^{tm1.1(KOMP)Vlcg},Tg(Cd4-cre)1Cwi/0 Genetic Background: B6.Cg-Orai1^tm1.1Hjm Orai2^{tm1.1(KOMP)Vlcg} Tg(Cd4-cre)1Cwi

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr