ENSMUSG00000049734


Mus musculus

Features
Gene ID: ENSMUSG00000049734
  
Biological name :Trex1
  
Synonyms : Q91XB0 / Three-prime repair exonuclease 1 / Trex1
  
Possible biological names infered from orthology : Q9NSU2
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: F2
Gene start: 109057933
Gene end: 109059734
  
Corresponding Affymetrix probe sets: 10596960 (MoGene1.0st)   1450672_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000050971
Ensembl peptide - ENSMUSP00000107684
NCBI entrez gene - 22040     See in Manteia.
MGI - MGI:1328317
RefSeq - NM_001012236
RefSeq - NM_011637
RefSeq Peptide - NP_001012236
RefSeq Peptide - NP_035767
swissprot - Q91XB0
Ensembl - ENSMUSG00000049734
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TREX1ENSG00000213689Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm42641 / TREX1* / Q9NSU2* / three prime repair exonuclease 1*ENSMUSG0000010538348
Trex2 / Q9R1A9 / three prime repair exonuclease 2 / Q9BQ50*ENSMUSG0000003137234


Protein motifs (from Interpro)
Interpro ID Name
 IPR012337  Ribonuclease H-like superfamily
 IPR013520  Exonuclease, RNase T/DNA polymerase III
 IPR036397  Ribonuclease H superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006259 DNA metabolic process IDA
 biological_processGO:0035458 cellular response to interferon-beta IDA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IDA
 molecular_functionGO:0003697 single-stranded DNA binding IDA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004527 exonuclease activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008296 3"-5"-exodeoxyribonuclease activity IDA
 molecular_functionGO:0008408 3"-5" exonuclease activity ISS
 molecular_functionGO:0008853 exodeoxyribonuclease III activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0032405 MutLalpha complex binding ISO
 molecular_functionGO:0032407 MutSalpha complex binding ISO
 molecular_functionGO:0032558 adenyl deoxyribonucleotide binding IDA
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Msr1tm1Csk/Msr1tm1Csk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000376 folliculitis "inflammatory reaction in hair follicles " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000688 lymphoid hyperplasia "increased cell number in lymphatic tissues" [J:62478]
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Allelic Composition: Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Msr1tm1Csk/Msr1tm1Csk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Msr1tm1Csk/Msr1tm1Csk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0000711 thymic cortex hypoplasia "reduced cell number in the outer portion of the thymus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Msr1tm1Csk/Msr1tm1Csk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
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Allelic Composition: Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
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Allelic Composition: Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Msr1tm1Csk/Msr1tm1Csk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Mavstm1Itl/Mavstm1Itl,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tcratm1Mom/Tcratm1Mom,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

Allelic Composition: Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

Allelic Composition: Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

Allelic Composition: Del(1Aim2-Ifi205)1Stsn/+,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

 MP:0001853 heart inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the heart" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Msr1tm1Csk/Msr1tm1Csk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

Allelic Composition: Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

Allelic Composition: Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

Allelic Composition: Del(1Aim2-Ifi205)1Stsn/+,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

 MP:0001855 atrial thrombosis "formation or presence of a thrombus in the atria of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Msr1tm1Csk/Msr1tm1Csk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0001856 myocarditis "inflammation of the heart walls" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Msr1tm1Csk/Msr1tm1Csk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Mavstm1Itl/Mavstm1Itl,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

Allelic Composition: Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

Allelic Composition: Del(1Aim2-Ifi205)1Stsn/+,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0001864 vasculitis "inflammation of a blood or lymph vessel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0001869 pancreas inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the pancreas " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0001870 salivary gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the salivary gland" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0001873 stomach inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the stomach" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Mavstm1Itl/Mavstm1Itl,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

Allelic Composition: Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

Allelic Composition: Del(1Aim2-Ifi205)1Stsn/+,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Msr1tm1Csk/Msr1tm1Csk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Mavstm1Itl/Mavstm1Itl,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

Allelic Composition: Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

Allelic Composition: Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

Allelic Composition: Del(1Aim2-Ifi205)1Stsn/+,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm1(tetO-cas9)Sho/Col1a1tm1(tetO-cas9)Sho
Genetic Background: B6.Cg-Col1a1tm1(tetO-cas9)Sho

 MP:0002362 abnormal spleen marginal zone morphology "anomalous structure of the area surrounding the marginal sinus and containing lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Msr1tm1Csk/Msr1tm1Csk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mb21d1tm1a(EUCOMM)Hmgu/Mb21d1tm1a(EUCOMM)Hmgu,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0002704 tubular nephritis "inflammation of the renal tubules" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tcratm1Mom/Tcratm1Mom,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0003140 dilated atria "an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Msr1tm1Csk/Msr1tm1Csk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

Allelic Composition: Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

Allelic Composition: Del(1Aim2-Ifi205)1Stsn/+,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

 MP:0003946 renal necrosis "pathological cell death in the kidney, usually due to irreversible damage" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Msr1tm1Csk/Msr1tm1Csk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004510 myositis "inflammation of skeletal muscle; local accumulation of fluid, plasma proteins, and leukocytes in the striated muscle" [MESH:C05.651.594]
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Allelic Composition: Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Mavstm1Itl/Mavstm1Itl,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tcratm1Mom/Tcratm1Mom,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

Allelic Composition: Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

Allelic Composition: Del(1Aim2-Ifi205)1Stsn/+,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

 MP:0004566 myocardial fiber degeneration "deterioration or destruction of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Msr1tm1Csk/Msr1tm1Csk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004801 increased susceptibility to systemic lupus erythematosus "greater likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Msr1tm1Csk/Msr1tm1Csk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Mavstm1Itl/Mavstm1Itl,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tcratm1Mom/Tcratm1Mom,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0004973 increased regulatory T cell number "greater number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0005330 cardiomyopathy "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]
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Allelic Composition: Msr1tm1Csk/Msr1tm1Csk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005350 increased susceptibility to autoimmune disorders "greater likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0008022 dilated heart ventricles "the lumenal space of the lower chambers of the heart is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

Allelic Composition: Trex1tm1.1Fwpe/Trex1+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0008097 increased plasma cell number "greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
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Allelic Composition: Msr1tm1Csk/Msr1tm1Csk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0008555 abnormal interferon secretion "anomaly in the production or release of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
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Allelic Composition: Msr1tm1Csk/Msr1tm1Csk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0008880 lacrimal gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the glands that secrete tears" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0009338 increased splenocyte number "increase in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0010019 liver vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the liver" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0011405 tubulointerstitial nephritis "diffuse or local inflammation and edema of the interstitial tissue of the kidney, including the renal tubules; usually secondary to drug sensitization, systemic infection, graft rejection, or autoimmune disease" [MGI:anna]
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Allelic Composition: Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0020519 renal glomerular immunoglobulin deposits "any anomalous accumulation of immunoglobulins in the renal glomerulus" [PMID:12764198, PMID:17685926]
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Allelic Composition: Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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