ENSMUSG00000049775


Mus musculus

Features
Gene ID: ENSMUSG00000049775
  
Biological name :Tmsb4x
  
Synonyms : P20065 / thymosin, beta 4, X chromosome / Tmsb4x
  
Possible biological names infered from orthology : O14604 / thymosin beta 4, Y-linked / TMSB4Y
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: F5
Gene start: 167207093
Gene end: 167209315
  
Corresponding Affymetrix probe sets: 10607865 (MoGene1.0st)   1415906_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000107795
Ensembl peptide - ENSMUSP00000107797
Ensembl peptide - ENSMUSP00000107798
NCBI entrez gene - 19241     See in Manteia.
MGI - MGI:99510
RefSeq - XM_006528759
RefSeq - NM_021278
RefSeq Peptide - NP_067253
swissprot - P20065
swissprot - Q6ZWX2
Ensembl - ENSMUSG00000049775
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tmsb4xENSDARG00000077777Danio rerio
 ENSGALG00000026383Gallus gallus
 O14604ENSG00000154620Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6ZWY8 / Tmsb10 / Thymosin beta-10 ENSMUSG0000007952375
Gm9844 / Q6ZWY8 / predicted pseudogene 9844 / P63313* / TMSB10* / thymosin beta 10*ENSMUSG0000009195575
Tmsb15b1 / P0CG35* / P0CG34* / TMSB15A* / TMSB15B* / thymosin beta 15a* / thymosin beta 15B*ENSMUSG0000008976868
Tmsb15l / thymosin beta 15b like / P0CG35* / P0CG34* / TMSB15A* / TMSB15B* / thymosin beta 15a* / thymosin beta 15B*ENSMUSG0000007295568
Tmsb15b2 / thymosin beta 15b2 / P0CG35* / P0CG34* / TMSB15A* / TMSB15B* / thymosin beta 15a* / thymosin beta 15B*ENSMUSG0000008999668
Tmsb15a / thymosin beta 15aENSMUSG0000006072666


Protein motifs (from Interpro)
Interpro ID Name
 IPR001152  Beta-thymosin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0014911 positive regulation of smooth muscle cell migration TAS
 biological_processGO:0030334 regulation of cell migration IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated TAS
 biological_processGO:0051152 positive regulation of smooth muscle cell differentiation TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0003785 actin monomer binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myo7aewaso/Myo7a+
Genetic Background: involves: C57BL/6J

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
Show

Allelic Composition: Myo7aewaso/Myo7a+
Genetic Background: involves: C57BL/6J

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Myo7aewaso/Myo7a+
Genetic Background: involves: C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dhx36tm1.2Pmt/Dhx36tm1.2Pmt,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * CBA

Allelic Composition: Tmsb4xtm1.1Chen/Tmsb4xtm1.1Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Tmsb4xtm1.1Chen/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Tmsb4xtm1.2Chen/Y,Tg(Nkx2-5-cre)9Eno/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Tmsb4xtm1.2Chen/Y,Tg(Myhca-cre)1Abel/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Myo7aewaso/Myo7a+
Genetic Background: involves: C57BL/6J

 MP:0004112 abnormal arteriole morphology "structural anomaly in the small diameter vessels that branch from the arteries and lead to the capillaries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Myo7aewaso/Myo7a+
Genetic Background: involves: C57BL/6J

 MP:0005244 hemopericardium "bleeding into the pericardial space" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Myo7aewaso/Myo7a+
Genetic Background: involves: C57BL/6J

 MP:0009698 heart hemorrhage "bleeding into the heart" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo7aewaso/Myo7a+
Genetic Background: involves: C57BL/6J

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Myo7aewaso/Myo7a+
Genetic Background: involves: C57BL/6J

Allelic Composition: Tmsb4xtm1Prri/Y
Genetic Background: B6.129-Tmsb4xtm1Prri

 MP:0011401 abnormal vascular smooth muscle development "anomaly in the process of forming the nonstriated, involuntary muscle tissue of the blood vessels" [MGI:smb]
Show

Allelic Composition: Myo7aewaso/Myo7a+
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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