ENSMUSG00000049940


Mus musculus

Features
Gene ID: ENSMUSG00000049940
  
Biological name :Pgrmc2
  
Synonyms : Membrane-associated progesterone receptor component 2 / Pgrmc2 / Q80UU9
  
Possible biological names infered from orthology : O15173 / progesterone receptor membrane component 2
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: B
Gene start: 41066326
Gene end: 41083046
  
Corresponding Affymetrix probe sets: 10497964 (MoGene1.0st)   1428714_at (Mouse Genome 430 2.0 Array)   1452882_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000056643
NCBI entrez gene - 70804     See in Manteia.
MGI - MGI:1918054
RefSeq - NM_027558
RefSeq Peptide - NP_081834
swissprot - Q80UU9
Ensembl - ENSMUSG00000049940
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pgrmc2ENSDARG00000030237Danio rerio
 O15173ENSG00000164040Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O55022 / Pgrmc1 / progesterone receptor membrane component 1 / O00264*ENSMUSG0000000637344


Protein motifs (from Interpro)
Interpro ID Name
 IPR001199  Cytochrome b5-like heme/steroid binding domain
 IPR036400  Cytochrome b5-like heme/steroid binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008150 biological_process ND
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0012505 endomembrane system IBA
 cellular_componentGO:0016020 membrane IBA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005496 steroid binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0020037 heme binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Pgrmc2tm1.1Jjp/Pgrmc2tm1.1Jjp,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Pgrmc1tm1.1Jjp/Pgrmc1tm1.1Jjp,Pgrmc2tm1.1Jjp/Pgrmc2tm1.1Jjp,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pgrmc2tm1.1Jjp/Pgrmc2tm1.1Jjp,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Pgrmc1tm1.1Jjp/Pgrmc1tm1.1Jjp,Pgrmc2tm1.1Jjp/Pgrmc2tm1.1Jjp,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004896 abnormal endometrium morphology "any structural anomaly of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy" [MESH:A05.360.319.679.490, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pgrmc2tm1.1Jjp/Pgrmc2tm1.1Jjp,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Pgrmc1tm1.1Jjp/Pgrmc1tm1.1Jjp,Pgrmc2tm1.1Jjp/Pgrmc2tm1.1Jjp,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005185 decreased circulating progesterone level "less than the normal blood concentration of this antiestrogenic steroid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:66817]
Show

Allelic Composition: Pgrmc2tm1.1Jjp/Pgrmc2tm1.1Jjp,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008876 decreased uterine NK cell number "reduced number of the uterine subset of the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Pgrmc2tm1.1Jjp/Pgrmc2tm1.1Jjp,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008995 early reproductive senescence "loss of reproductive capacity occurring at an earlier than expected age" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pgrmc2tm1.1Jjp/Pgrmc2tm1.1Jjp,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Pgrmc1tm1.1Jjp/Pgrmc1tm1.1Jjp,Pgrmc2tm1.1Jjp/Pgrmc2tm1.1Jjp,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009082 uterus cysts "presence of fluid-filled structures inside the lumen of the uterus; usually refers to benign growths" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pgrmc2tm1.1Jjp/Pgrmc2tm1.1Jjp,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Pgrmc1tm1.1Jjp/Pgrmc1tm1.1Jjp,Pgrmc2tm1.1Jjp/Pgrmc2tm1.1Jjp,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009094 abnormal endometrial gland morphology "any structural anomaly of the numerous simple or branched tubular glands lined by ciliated columnar epithelium and found in the mucus membrane of the uterus which secrete mucus, lipids, glycogen, and protein; endometrial glands and their secretions (termed histotroph) are critical regulators of peri-implantation embryo survival and implantation as well as establishment of uterine receptivity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pgrmc2tm1.1Jjp/Pgrmc2tm1.1Jjp,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Pgrmc1tm1.1Jjp/Pgrmc1tm1.1Jjp,Pgrmc2tm1.1Jjp/Pgrmc2tm1.1Jjp,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009251 enlarged endometrial glands "increase in the average size of the simple or branched tubular glands located in the mucous membrane of the uterus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pgrmc2tm1.1Jjp/Pgrmc2tm1.1Jjp,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Pgrmc2tm1.1Jjp/Pgrmc2+,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Pgrmc1tm1.1Jjp/Pgrmc1tm1.1Jjp,Pgrmc2tm1.1Jjp/Pgrmc2tm1.1Jjp,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Pgrmc1tm1.1Jjp/Pgrmc1tm1.1Jjp,Pgrmc2tm1.1Jjp/Pgrmc2+,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0013401 increased endometrial gland number "greater than normal numbers of the simple or branched tubular glands found in the mucus membrane of the uterus" [MGI:Anna]
Show

Allelic Composition: Pgrmc2tm1.1Jjp/Pgrmc2tm1.1Jjp,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Pgrmc1tm1.1Jjp/Pgrmc1tm1.1Jjp,Pgrmc2tm1.1Jjp/Pgrmc2tm1.1Jjp,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr