ENSMUSG00000006373


Mus musculus

Features
Gene ID: ENSMUSG00000006373
  
Biological name :Pgrmc1
  
Synonyms : O55022 / Pgrmc1 / progesterone receptor membrane component 1
  
Possible biological names infered from orthology : O00264
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A3.3
Gene start: 36598206
Gene end: 36606079
  
Corresponding Affymetrix probe sets: 10599200 (MoGene1.0st)   1423451_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000073061
NCBI entrez gene - 53328     See in Manteia.
MGI - MGI:1858305
RefSeq - NM_016783
RefSeq Peptide - NP_058063
swissprot - O55022
swissprot - Q3TXU8
Ensembl - ENSMUSG00000006373
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pgrmc1ENSDARG00000054172Danio rerio
 PGRMC1ENSGALG00000020260Gallus gallus
 O00264ENSG00000101856Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pgrmc2 / Q80UU9 / Membrane-associated progesterone receptor component 2 / O15173* / progesterone receptor membrane component 2*ENSMUSG0000004994049


Protein motifs (from Interpro)
Interpro ID Name
 IPR001199  Cytochrome b5-like heme/steroid binding domain
 IPR036400  Cytochrome b5-like heme/steroid binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0012505 endomembrane system IBA
 cellular_componentGO:0016020 membrane IBA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0005496 steroid binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0020037 heme binding IBA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Pgrmc1tm1.1Jjp/Pgrmc1tm1.1Jjp,Pgrmc2tm1.1Jjp/Pgrmc2tm1.1Jjp,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pgrmc1tm1.1Jjp/Pgrmc1tm1.1Jjp,Pgrmc2tm1.1Jjp/Pgrmc2tm1.1Jjp,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002067 abnormal sensory capabilities/reflexes/nociception "inability or altered ability to respond to a sensory stimulus" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: SykM2Btlr/Syk+
Genetic Background: C57BL/6J-SykM2Btlr

 MP:0004896 abnormal endometrium morphology "any structural anomaly of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy" [MESH:A05.360.319.679.490, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pgrmc1tm1.1Jjp/Pgrmc1tm1.1Jjp,Pgrmc2tm1.1Jjp/Pgrmc2tm1.1Jjp,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008995 early reproductive senescence "loss of reproductive capacity occurring at an earlier than expected age" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pgrmc1tm1.1Jjp/Pgrmc1tm1.1Jjp,Pgrmc2tm1.1Jjp/Pgrmc2tm1.1Jjp,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009082 uterus cysts "presence of fluid-filled structures inside the lumen of the uterus; usually refers to benign growths" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pgrmc1tm1.1Jjp/Pgrmc1tm1.1Jjp,Pgrmc2tm1.1Jjp/Pgrmc2tm1.1Jjp,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009094 abnormal endometrial gland morphology "any structural anomaly of the numerous simple or branched tubular glands lined by ciliated columnar epithelium and found in the mucus membrane of the uterus which secrete mucus, lipids, glycogen, and protein; endometrial glands and their secretions (termed histotroph) are critical regulators of peri-implantation embryo survival and implantation as well as establishment of uterine receptivity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pgrmc1tm1.1Jjp/Pgrmc1tm1.1Jjp,Pgrmc2tm1.1Jjp/Pgrmc2tm1.1Jjp,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009251 enlarged endometrial glands "increase in the average size of the simple or branched tubular glands located in the mucous membrane of the uterus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pgrmc1tm1.1Jjp/Pgrmc1tm1.1Jjp,Pgrmc2tm1.1Jjp/Pgrmc2tm1.1Jjp,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Pgrmc1tm1.1Jjp/Pgrmc1tm1.1Jjp,Pgrmc2tm1.1Jjp/Pgrmc2+,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0013401 increased endometrial gland number "greater than normal numbers of the simple or branched tubular glands found in the mucus membrane of the uterus" [MGI:Anna]
Show

Allelic Composition: Pgrmc1tm1.1Jjp/Pgrmc1tm1.1Jjp,Pgrmc2tm1.1Jjp/Pgrmc2tm1.1Jjp,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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