ENSMUSG00000050440


Mus musculus

Features
Gene ID: ENSMUSG00000050440
  
Biological name :Hamp
  
Synonyms : Hamp / Hepcidin / Q9EQ21
  
Possible biological names infered from orthology : hepcidin antimicrobial peptide / P81172
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B1
Gene start: 30942368
Gene end: 30944032
  
Corresponding Affymetrix probe sets: 10562169 (MoGene1.0st)   1419196_at (Mouse Genome 430 2.0 Array)   1419197_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000055404
NCBI entrez gene - 84506     See in Manteia.
MGI - MGI:1933533
RefSeq - NM_032541
RefSeq Peptide - NP_115930
swissprot - Q9EQ21
Ensembl - ENSMUSG00000050440
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HAMPENSG00000105697Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hamp2 / Q80T19 / Hepcidin-2 / HAMP* / P81172* / hepcidin antimicrobial peptide*ENSMUSG0000005697889


Protein motifs (from Interpro)
Interpro ID Name
 IPR010500  Hepcidin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0002262 myeloid cell homeostasis IMP
 biological_processGO:0006879 cellular iron ion homeostasis IDA
 biological_processGO:0007259 JAK-STAT cascade IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0031668 cellular response to extracellular stimulus TAS
 biological_processGO:0034760 negative regulation of iron ion transmembrane transport IGI
 biological_processGO:0042742 defense response to bacterium IMP
 biological_processGO:0043032 positive regulation of macrophage activation IMP
 biological_processGO:0045779 negative regulation of bone resorption IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0050728 negative regulation of inflammatory response IGI
 biological_processGO:0050832 defense response to fungus IDA
 biological_processGO:0055072 iron ion homeostasis IMP
 biological_processGO:1903364 positive regulation of cellular protein catabolic process IDA
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0005507 copper ion binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Pou1f1dw/Pou1f1dw-J
Genetic Background: (DW/J x C3H/HeJ)F1

 MP:0001770 abnormal iron level "anomalous concentrations of this metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ikbkbtm1Cgn/Ikbkbtm1Cgn,Il22tm1Jcrd/Il22tm1Jcrd,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pou1f1dw/Pou1f1dw-J
Genetic Background: (DW/J x C3H/HeJ)F1

 MP:0004152 abnormal circulating iron level "anomalous blood concentration of this metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pou1f1dw/Pou1f1dw-J
Genetic Background: (DW/J x C3H/HeJ)F1

 MP:0005639 hemosiderosis "condition in which there is a generalized increase in the iron stores of body tissues, particularly of liver and the reticuloendothelial system, without demonstrable tissue damage" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pou1f1dw/Pou1f1dw-J
Genetic Background: (DW/J x C3H/HeJ)F1

 MP:0008807 increased liver iron level "increase in the amount of iron present in the liver tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ikbkbtm1Cgn/Ikbkbtm1Cgn,Il22tm1Jcrd/Il22tm1Jcrd,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0008808 decreased spleen iron level "reduction in the amount of iron present in the spleen tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pou1f1dw/Pou1f1dw-J
Genetic Background: (DW/J x C3H/HeJ)F1

 MP:0008810 increased circulating iron level "elevation in the concentration of iron in the blood" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc26a4tm1.1Dontu/Slc26a4tm1.1Dontu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hamp/Hamp2tm1.1(HAMP)Bjs/Hamp/Hamp2tm1.1(HAMP)Bjs
Genetic Background: involves: 129 * NTac:NIHBS

Allelic Composition: Hamptm2.1Svl/Hamptm2.1Svl
Genetic Background: involves: FVB/N

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ank1ity16/Ank1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * DBA/2J

 MP:0011890 increased circulating ferritin level "elevated concentration in the blood of ferritin, a ubiquitous intracellular protein that stores iron and releases it in a controlled fashion; some ferritin is also found in the blood and is measured in tests for overall iron levels, anemia and chronic diseases" [MGI:csmith]
Show

Allelic Composition: Pou1f1dw/Pou1f1dw-J
Genetic Background: (DW/J x C3H/HeJ)F1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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