ENSMUSG00000051316


Mus musculus

Features
Gene ID: ENSMUSG00000051316
  
Biological name :Taf7
  
Synonyms : Q9R1C0 / Taf7 / Transcription initiation factor TFIID subunit 7
  
Possible biological names infered from orthology : Q15545 / TATA-box binding protein associated factor 7
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: B3
Gene start: 37640491
Gene end: 37644204
  
Corresponding Affymetrix probe sets: 10458424 (MoGene1.0st)   1423169_at (Mouse Genome 430 2.0 Array)   1423170_at (Mouse Genome 430 2.0 Array)   1441982_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000065645
NCBI entrez gene - 24074     See in Manteia.
MGI - MGI:1346348
RefSeq - NM_175770
RefSeq Peptide - NP_786964
swissprot - Q9R1C0
Ensembl - ENSMUSG00000051316
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 taf7ENSDARG00000019572Danio rerio
 TAF7ENSGALG00000004999Gallus gallus
 TAF7ENSG00000178913Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
4933416C03Rik / RIKEN cDNA 4933416C03 gene / TAF7L* / Q5H9L4* / TATA-box binding protein associated factor 7 like*ENSMUSG0000007473450
Taf7l / Q9D3R9 / Transcription initiation factor TFIID subunit 7-like / Q5H9L4* / TATA-box binding protein associated factor 7 like*ENSMUSG0000000959647


Protein motifs (from Interpro)
Interpro ID Name
 IPR006751  TAFII55 protein, conserved region


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006352 DNA-templated transcription, initiation IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter ISO
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0030520 intracellular estrogen receptor signaling pathway IDA
 biological_processGO:0035067 negative regulation of histone acetylation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051123 RNA polymerase II transcriptional preinitiation complex assembly IBA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005669 transcription factor TFIID complex ISO
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0008024 cyclin/CDK positive transcription elongation factor complex IEA
 cellular_componentGO:0033276 transcription factor TFTC complex IEA
 cellular_componentGO:0071339 MLL1 complex IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0035035 histone acetyltransferase binding IEA
 molecular_functionGO:0042809 vitamin D receptor binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046966 thyroid hormone receptor binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0061628 H3K27me3 modified histone binding IEA


Pathways (from Reactome)
Pathway description
RNA Polymerase II Pre-transcription Events
Regulation of TP53 Activity through Phosphorylation
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Initiation And Promoter Clearance


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
Show

Allelic Composition: Tcf7l2tm2.1Cle/Tcf7l2tm2.1Cle,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Tcf7l2tm2.1Cle/Tcf7l2tm2.1Cle,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Taf7tm1.1Dss/Taf7tm1.2Dss,Tg(Cd8a*-cre)#Asin/0
Genetic Background: involves: C57BL/6

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tcf7l2tm2.1Cle/Tcf7l2tm2.1Cle,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tcf7l2tm2.1Cle/Tcf7l2tm2.1Cle,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Taf7tm1.1Dss/Taf7tm1.2Dss,Tg(Cd8a*-cre)#Asin/0
Genetic Background: involves: C57BL/6

 MP:0003763 abnormal thymus physiology "anomalous function of the primary lymphoid organ that is required for immune system development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tcf7l2tm2.1Cle/Tcf7l2tm2.1Cle,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Taf7tm1.1Dss/Taf7tm1.2Dss,Tg(Cd8a*-cre)#Asin/0
Genetic Background: involves: C57BL/6

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Tcf7l2tm2.1Cle/Tcf7l2tm2.1Cle,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Tcf7l2tm2.1Cle/Tcf7l2tm2.1Cle,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Taf7tm1.1Dss/Taf7tm1.2Dss,Tg(Cd8a*-cre)#Asin/0
Genetic Background: involves: C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Taf7tm1.1Dss/Taf7tm1.2Dss,Tg(Cd8a*-cre)#Asin/0
Genetic Background: involves: C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tcf7l2tm2.1Cle/Tcf7l2tm2.1Cle,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Taf7tm1.1Dss/Taf7tm1.2Dss,Tg(Cd8a*-cre)#Asin/0
Genetic Background: involves: C57BL/6

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tcf7l2tm2.1Cle/Tcf7l2tm2.1Cle,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Taf7tm1.1Dss/Taf7tm1.2Dss,Tg(Cd8a*-cre)#Asin/0
Genetic Background: involves: C57BL/6

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Taf7tm1.1Dss/Taf7tm1.2Dss,Tg(Cd8a*-cre)#Asin/0
Genetic Background: involves: C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Tcf7l2tm2.1Cle/Tcf7l2tm2.1Cle,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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