ENSMUSG00000051582


Mus musculus

Features
Gene ID: ENSMUSG00000051582
  
Biological name :Otud6a
  
Synonyms : Otud6a / OTU domain-containing protein 6A / Q6IE21
  
Possible biological names infered from orthology : OTU deubiquitinase 6A / Q7L8S5
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: C3
Gene start: 100429013
Gene end: 100429885
  
Corresponding Affymetrix probe sets: 10600971 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000059861
NCBI entrez gene - 408193     See in Manteia.
MGI - MGI:3644685
RefSeq - NM_001163191
RefSeq Peptide - NP_001156663
swissprot - Q6IE21
Ensembl - ENSMUSG00000051582
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 otud6bENSDARG00000102705Danio rerio
 OTUD6BENSGALG00000041337Gallus gallus
 OTUD6AENSG00000189401Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Otud6b / OTU domain containing 6B / Q8N6M0*ENSMUSG0000004055051


Protein motifs (from Interpro)
Interpro ID Name
 IPR003323  OTU domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0035523 protein K29-linked deubiquitination IEA
 biological_processGO:0035871 protein K11-linked deubiquitination IEA
 biological_processGO:1990167 protein K27-linked deubiquitination IEA
 biological_processGO:1990168 protein K33-linked deubiquitination IEA
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Otub1tm1b(EUCOMM)Hmgu/Otub1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Otub1tm1b(EUCOMM)Hmgu/H

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Otub1tm1b(EUCOMM)Hmgu/Otub1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Otub1tm1b(EUCOMM)Hmgu/H

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
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Allelic Composition: Otub1tm1b(EUCOMM)Hmgu/Otub1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Otub1tm1b(EUCOMM)Hmgu/H

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Otub1tm1b(EUCOMM)Hmgu/Otub1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Otub1tm1b(EUCOMM)Hmgu/H

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Otub1tm1b(EUCOMM)Hmgu/Otub1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Otub1tm1b(EUCOMM)Hmgu/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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