ENSMUSG00000051998


Mus musculus

Features
Gene ID: ENSMUSG00000051998
  
Biological name :Lax1
  
Synonyms : Lax1 / Lymphocyte transmembrane adapter 1 / Q8BHB3
  
Possible biological names infered from orthology : lymphocyte transmembrane adaptor 1 / Q8IWV1
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: E4
Gene start: 133679091
Gene end: 133690108
  
Corresponding Affymetrix probe sets: 10468898 (MoGene1.0st)   1438687_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000131126
Ensembl peptide - ENSMUSP00000140039
NCBI entrez gene - 240754     See in Manteia.
MGI - MGI:2443362
RefSeq - XM_006529557
RefSeq - NM_001159649
RefSeq - NM_172842
RefSeq Peptide - NP_001153121
RefSeq Peptide - NP_766430
swissprot - Q8BHB3
swissprot - A0A087WQ47
Ensembl - ENSMUSG00000051998
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LAX1ENSG00000122188Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR031393  Lymphocyte transmembrane adapter 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000188 inactivation of MAPK activity ISO
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0035556 intracellular signal transduction ISO
 biological_processGO:0042113 B cell activation ISO
 biological_processGO:0046649 lymphocyte activation IMP
 biological_processGO:0048305 immunoglobulin secretion IMP
 biological_processGO:0050851 antigen receptor-mediated signaling pathway IMP
 biological_processGO:0050868 negative regulation of T cell activation ISO
 biological_processGO:0051249 regulation of lymphocyte activation IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane ISO
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0042169 SH2 domain binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0002359 abnormal spleen germinal center morphology "anomalous structure or formation of the area of the spleen in which activated follicles are located" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0008826 abnormal splenic cell ratio "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
Show

Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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