ENSMUSG00000052384


Mus musculus

Features
Gene ID: ENSMUSG00000052384
  
Biological name :Nrros
  
Synonyms : Mus musculus negative regulator of reactive oxygen species (Nrros), transcript variant 2, mRNA. / Nrros / Q8BMT4
  
Possible biological names infered from orthology : negative regulator of reactive oxygen species / Q86YC3
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: B2
Gene start: 32142785
Gene end: 32165594
  
Corresponding Affymetrix probe sets: 10439058 (MoGene1.0st)   1451174_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121492
Ensembl peptide - ENSMUSP00000119349
Ensembl peptide - ENSMUSP00000122290
Ensembl peptide - ENSMUSP00000097571
Ensembl peptide - ENSMUSP00000110817
Ensembl peptide - ENSMUSP00000110819
Ensembl peptide - ENSMUSP00000116388
NCBI entrez gene - 224109     See in Manteia.
MGI - MGI:2445095
RefSeq - XM_017316962
RefSeq - XM_006522073
RefSeq - XM_006522074
RefSeq - XM_006522075
RefSeq - XM_006522076
RefSeq - XM_006522077
RefSeq - XM_006522078
RefSeq - NM_001347181
RefSeq - NM_001347182
RefSeq - NM_146069
RefSeq Peptide - NP_666181
RefSeq Peptide - NP_001334110
RefSeq Peptide - NP_001334111
swissprot - D3Z755
swissprot - Q8BMT4
swissprot - D3Z2Y0
Ensembl - ENSMUSG00000052384
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nrrosENSDARG00000071491Danio rerio
 ENSGALG00000006402Gallus gallus
 NRROSENSG00000174004Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lrrc32 / leucine rich repeat containing 32 / Q14392*ENSMUSG0000009095828


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006801 superoxide metabolic process IMP
 biological_processGO:0006954 inflammatory response IMP
 biological_processGO:0006955 immune response IMP
 biological_processGO:0030433 ubiquitin-dependent ERAD pathway TAS
 biological_processGO:0045087 innate immune response IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002409 decreased susceptibility to infection "reduced likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ncr1m1J/Ncr1m1J,Pepcb/Pepcb,Ptprca/Ptprca
Genetic Background: B6.SJL-Ptprca Pepcb/BoyJ

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ncr1m1J/Ncr1m1J,Pepcb/Pepcb,Ptprca/Ptprca
Genetic Background: B6.SJL-Ptprca Pepcb/BoyJ

Allelic Composition: Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo,Nrrostm1Wouy/Nrrostm1Wouy
Genetic Background: involves: 129P2/OlaHsd

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ncr1m1J/Ncr1m1J,Pepcb/Pepcb,Ptprca/Ptprca
Genetic Background: B6.SJL-Ptprca Pepcb/BoyJ

Allelic Composition: Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo,Nrrostm1Wouy/Nrrostm1Wouy
Genetic Background: involves: 129P2/OlaHsd

 MP:0009858 abnormal cellular extravasation "any anomaly in the migration of leukocytes from the blood vessels into the surrounding tissue" [GO:0045123]
Show

Allelic Composition: Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo,Nrrostm1Wouy/Nrrostm1Wouy
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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