ENSMUSG00000053030


Mus musculus

Features
Gene ID: ENSMUSG00000053030
  
Biological name :Spink2
  
Synonyms : Q8BMY7 / serine peptidase inhibitor, Kazal type 2 / Spink2
  
Possible biological names infered from orthology : P20155
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: C3.3
Gene start: 77205107
Gene end: 77211471
  
Corresponding Affymetrix probe sets: 10530827 (MoGene1.0st)   1454710_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113823
Ensembl peptide - ENSMUSP00000067117
Ensembl peptide - ENSMUSP00000112806
NCBI entrez gene - 69982     See in Manteia.
MGI - MGI:1917232
RefSeq - XM_011249564
RefSeq - NM_001289764
RefSeq - NM_001289767
RefSeq - NM_001289768
RefSeq - NM_183284
RefSeq Peptide - NP_001276697
RefSeq Peptide - NP_899107
RefSeq Peptide - NP_001276696
RefSeq Peptide - NP_001276693
swissprot - D3Z3X9
swissprot - D3YTY0
swissprot - Q8BMY7
Ensembl - ENSMUSG00000053030
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-203a12.3ENSDARG00000099689Danio rerio
 si:dkey-203a12.6ENSDARG00000100051Danio rerio
 si:dkey-203a12.8ENSDARG00000101290Danio rerio
 si:dkey-77g12.1ENSDARG00000103833Danio rerio
 si:dkey-77g12.4ENSDARG00000103336Danio rerio
 SPINK2ENSDARG00000102868Danio rerio
 zgc:158852ENSDARG00000102076Danio rerio
 P20155ENSG00000128040Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002350  Kazal domain
 IPR036058  Kazal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002176 male germ cell proliferation IMP
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007286 spermatid development IMP
 biological_processGO:0008584 male gonad development IMP
 biological_processGO:0009566 fertilization IMP
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0060046 regulation of acrosome reaction IBA
 biological_processGO:0072520 seminiferous tubule development IMP
 biological_processGO:1900004 negative regulation of serine-type endopeptidase activity IDA
 cellular_componentGO:0001669 acrosomal vesicle IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0043005 neuron projection IDA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0030414 peptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Sgms2tm1Kenw/Sgms2tm1Kenw
Genetic Background: B6.129S2-Sgms2tm1Kenw

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Sgms2tm1Kenw/Sgms2tm1Kenw
Genetic Background: B6.129S2-Sgms2tm1Kenw

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Sgms2tm1Kenw/Sgms2tm1Kenw
Genetic Background: B6.129S2-Sgms2tm1Kenw

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Spata22tm1b(KOMP)Wtsi/Spata22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Spata22tm1b(KOMP)Wtsi/Ucd

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sgms2tm1Kenw/Sgms2tm1Kenw
Genetic Background: B6.129S2-Sgms2tm1Kenw

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sgms2tm1Kenw/Sgms2tm1Kenw
Genetic Background: B6.129S2-Sgms2tm1Kenw

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Spata22tm1b(KOMP)Wtsi/Spata22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Spata22tm1b(KOMP)Wtsi/Ucd

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Sgms2tm1Kenw/Sgms2tm1Kenw
Genetic Background: B6.129S2-Sgms2tm1Kenw

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sgms2tm1Kenw/Sgms2tm1Kenw
Genetic Background: B6.129S2-Sgms2tm1Kenw

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sgms2tm1Kenw/Sgms2tm1Kenw
Genetic Background: B6.129S2-Sgms2tm1Kenw

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sgms2tm1Kenw/Sgms2tm1Kenw
Genetic Background: B6.129S2-Sgms2tm1Kenw

 MP:0009237 kinked sperm flagellum "a sharp bend or zigzag in the sperm tail" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sgms2tm1Kenw/Sgms2tm1Kenw
Genetic Background: B6.129S2-Sgms2tm1Kenw

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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