ENSMUSG00000053469


Mus musculus

Features
Gene ID: ENSMUSG00000053469
  
Biological name :Tg
  
Synonyms : O08710 / Tg / Thyroglobulin
  
Possible biological names infered from orthology : P01266
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: D2
Gene start: 66670753
Gene end: 66850721
  
Corresponding Affymetrix probe sets: 10424493 (MoGene1.0st)   1450790_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000070239
Ensembl peptide - ENSMUSP00000126454
Ensembl peptide - ENSMUSP00000155392
NCBI entrez gene - 21819     See in Manteia.
MGI - MGI:98733
RefSeq - XM_006520745
RefSeq - NM_009375
RefSeq Peptide - NP_033401
swissprot - A6P7M8
swissprot - O08710
swissprot - F6XYF6
Ensembl - ENSMUSG00000053469
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tgENSDARG00000020084Danio rerio
 TGENSGALG00000039509Gallus gallus
 TGENSG00000042832Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000716  Thyroglobulin type-1
 IPR002018  Carboxylesterase, type B
 IPR011641  Tyrosine-protein kinase ephrin type A/B receptor-like
 IPR016324  Thyroglobulin
 IPR019819  Carboxylesterase type B, conserved site
 IPR029058  Alpha/Beta hydrolase fold
 IPR036857  Thyroglobulin type-1 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0015705 iodide transport IMP
 biological_processGO:0030878 thyroid gland development IEA
 biological_processGO:0031641 regulation of myelination IMP
 biological_processGO:0042403 thyroid hormone metabolic process IMP
 biological_processGO:0042446 hormone biosynthetic process IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 molecular_functionGO:0005179 hormone activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cdh23v-10J/Cdh23v-10J
Genetic Background: involves: BALB/cByJ * C57BL/6

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdh23v-10J/Cdh23v-10J
Genetic Background: involves: BALB/cByJ * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Cdh23v-10J/Cdh23v-10J
Genetic Background: involves: BALB/cByJ * C57BL/6

Allelic Composition: Tgm1Btlr/Tgm1Btlr
Genetic Background: C57BL/6J-Tgm1Btlr

Allelic Composition: Tgm2Btlr/Tgm2Btlr
Genetic Background: C57BL/6J-Tgm2Btlr

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Ptprcnim/Ptprcnim
Genetic Background: C57BL/6JAnu-Ptprcnim

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Cdh23v-10J/Cdh23v-10J
Genetic Background: involves: BALB/cByJ * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptprcnim/Ptprcnim
Genetic Background: C57BL/6JAnu-Ptprcnim

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdh23v-10J/Cdh23v-10J
Genetic Background: involves: BALB/cByJ * C57BL/6

 MP:0002427 dwarfism "abnormally undersized with disproportionate body parts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdh23v-10J/Cdh23v-10J
Genetic Background: involves: BALB/cByJ * C57BL/6

 MP:0002865 increased growth rate "accelerated time to reach a developmental stage or stages" [J:32208, il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdh23v-10J/Cdh23v-10J
Genetic Background: involves: BALB/cByJ * C57BL/6

 MP:0004696 abnormal thyroid follicle morphology "any structural abnormality of the small spherical vesicular components of the thyroid gland that are lined with epithelium and contain a colloid substance that both serves as a reservoir of materials for thyroid hormone production and stores thyroid hormones" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Cdh23v-10J/Cdh23v-10J
Genetic Background: involves: BALB/cByJ * C57BL/6

 MP:0004697 abnormal thyroid follicular cell "any structural anomaly of the thyroxine-producing follicular cells derived from the thyroid diverticulum which evaginates from the endodermal epithelium of the embryonic pharyngeal floor" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh23v-10J/Cdh23v-10J
Genetic Background: involves: BALB/cByJ * C57BL/6

 MP:0005122 increased circulating thyroid-stimulating hormone level "greater than expected blood concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdh23v-10J/Cdh23v-10J
Genetic Background: involves: BALB/cByJ * C57BL/6

 MP:0005355 enlarged thyroid gland "increased size of the endocrine gland located in the front and to the sides of the upper part of the trachea, and which secretes thyroid hormone and calcitonin " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:85158, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdh23v-10J/Cdh23v-10J
Genetic Background: involves: BALB/cByJ * C57BL/6

Allelic Composition: Tgcog/Tgcog
Genetic Background: involves: AKR/J * C57BL/6By

 MP:0005478 decreased circulating thyroxine level "less than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cdh23v-10J/Cdh23v-10J
Genetic Background: involves: BALB/cByJ * C57BL/6

Allelic Composition: Tgcog/Tgcog
Genetic Background: involves: AKR/J * C57BL/6By

 MP:0005479 decreased circulating triiodothyronine level "less than the normal blood concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tgcog/Tgcog
Genetic Background: involves: AKR/J * C57BL/6By

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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