ENSMUSG00000054199


Mus musculus

Features
Gene ID: ENSMUSG00000054199
  
Biological name :Gon4l
  
Synonyms : Gon4l / gon-4-like (C.elegans)
  
Possible biological names infered from orthology : gon-4 like / Q3T8J9 / Q9H869 / YY1AP1 / YY1 associated protein 1
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F1
Gene start: 88835231
Gene end: 88910103
  
Corresponding Affymetrix probe sets: 10493317 (MoGene1.0st)   1424385_at (Mouse Genome 430 2.0 Array)   1430680_a_at (Mouse Genome 430 2.0 Array)   1431314_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000148624
Ensembl peptide - ENSMUSP00000080397
Ensembl peptide - ENSMUSP00000088461
Ensembl peptide - ENSMUSP00000103122
NCBI entrez gene - 76022     See in Manteia.
MGI - MGI:1917579
RefSeq - XM_017319800
RefSeq - XM_017319795
RefSeq - XM_017319796
RefSeq - XM_017319797
RefSeq - XM_017319798
RefSeq - XM_017319799
RefSeq - NM_001242372
RefSeq - NM_027389
RefSeq - XM_006502237
RefSeq - XM_006502238
RefSeq - XM_006502239
RefSeq - XM_006502240
RefSeq - XM_017319793
RefSeq - XM_017319794
RefSeq Peptide - NP_081665
RefSeq Peptide - NP_001229301
swissprot - K4DI71
swissprot - E9Q507
swissprot - A0A1D5RM47
Ensembl - ENSMUSG00000054199
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gon4lENSDARG00000005867Danio rerio
 si:dkey-27c15.3ENSDARG00000056847Danio rerio
 ENSGALG00000014643Gallus gallus
 GON4LENSG00000116580Homo sapiens
 Q9H869ENSG00000163374Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003822  Paired amphipathic helix
 IPR009057  Homeobox-like domain superfamily
 IPR017877  Myb-like domain
 IPR033277  GON-4-like protein
 IPR036600  Paired amphipathic helix superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0030183 B cell differentiation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003714 transcription corepressor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000621 salivary adenocarcinoma "malignant neoplasm of the secreting cells of the salivary gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mir451atm1.2Doca/Mir451atm1.2Doca
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/cJ

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mir451atm1.2Doca/Mir451atm1.2Doca
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/cJ

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
Show

Allelic Composition: Mir451atm1.2Doca/Mir451atm1.2Doca
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/cJ

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Mir451atm1.2Doca/Mir451atm1.2Doca
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/cJ

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
Show

Allelic Composition: Mir451atm1.2Doca/Mir451atm1.2Doca
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/cJ

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mir451atm1.2Doca/Mir451atm1.2Doca
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/cJ

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mir451atm1.2Doca/Mir451atm1.2Doca
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/cJ

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mir451atm1.2Doca/Mir451atm1.2Doca
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/cJ

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mir451atm1.2Doca/Mir451atm1.2Doca
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/cJ

 MP:0008071 absent B cells "absence of lymphocytes that expresses membrane-bound antibody, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mir451atm1.2Doca/Mir451atm1.2Doca
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/cJ

 MP:0008208 decreased pro-B cell number "reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mir451atm1.2Doca/Mir451atm1.2Doca
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/cJ

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mir451atm1.2Doca/Mir451atm1.2Doca
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/cJ

 MP:0008479 decreased spleen white pulp amount "reduction in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mir451atm1.2Doca/Mir451atm1.2Doca
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/cJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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