ENSMUSG00000054428


Mus musculus

Features
Gene ID: ENSMUSG00000054428
  
Biological name :Atpif1
  
Synonyms : ATPase inhibitor, mitochondrial / Atpif1 / O35143
  
Possible biological names infered from orthology : ATP5IF1 / ATP synthase inhibitory factor subunit 1 / Q9UII2
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D2.3
Gene start: 132530555
Gene end: 132533659
  
Corresponding Affymetrix probe sets: 10516943 (MoGene1.0st)   1434198_at (Mouse Genome 430 2.0 Array)   1448770_a_at (Mouse Genome 430 2.0 Array)   1453681_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000133099
Ensembl peptide - ENSMUSP00000064282
NCBI entrez gene - 11983     See in Manteia.
MGI - MGI:1196457
RefSeq - NM_007512
RefSeq Peptide - NP_031538
swissprot - E9PV44
swissprot - O35143
Ensembl - ENSMUSG00000054428
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A3KNL5ENSDARG00000067975Danio rerio
 Q1LYB6ENSDARG00000044092Danio rerio
 ATP5IF1ENSGALG00000038672Gallus gallus
 Q9UII2ENSG00000130770Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007648  Mitochondrial ATPase inhibitor


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001937 negative regulation of endothelial cell proliferation IEA
 biological_processGO:0006783 heme biosynthetic process IEA
 biological_processGO:0030218 erythrocyte differentiation IEA
 biological_processGO:0032780 negative regulation of ATPase activity ISO
 biological_processGO:0051260 protein homooligomerization ISS
 biological_processGO:0051289 protein homotetramerization ISS
 biological_processGO:0051346 negative regulation of hydrolase activity IEA
 biological_processGO:0051882 mitochondrial depolarization IEA
 biological_processGO:0072593 reactive oxygen species metabolic process IMP
 biological_processGO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IMP
 biological_processGO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process IEA
 biological_processGO:1903214 regulation of protein targeting to mitochondrion IEA
 biological_processGO:1903578 regulation of ATP metabolic process IEA
 biological_processGO:1904925 positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005753 mitochondrial proton-transporting ATP synthase complex IEA
 cellular_componentGO:0009986 cell surface IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding ISS
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0042030 ATPase inhibitor activity ISO
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0043532 angiostatin binding IEA
 molecular_functionGO:0051117 ATPase binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Asxl1tm1a(EUCOMM)Wtsi/Asxl1+
Genetic Background: B6Dnk;B6Brd;B6N-Asxl1tm1a(EUCOMM)Wtsi Tyrc-Brd/WtsiH

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Asxl1tm1a(EUCOMM)Wtsi/Asxl1+
Genetic Background: B6Dnk;B6Brd;B6N-Asxl1tm1a(EUCOMM)Wtsi Tyrc-Brd/WtsiH

 MP:0002966 decreased circulating alkaline phosphatase level "reduced activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Asxl1tm1a(EUCOMM)Wtsi/Asxl1+
Genetic Background: B6Dnk;B6Brd;B6N-Asxl1tm1a(EUCOMM)Wtsi Tyrc-Brd/WtsiH

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Asxl1tm1a(EUCOMM)Wtsi/Asxl1+
Genetic Background: B6Dnk;B6Brd;B6N-Asxl1tm1a(EUCOMM)Wtsi Tyrc-Brd/WtsiH

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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